David Ginsburg Lab

We study the molecular genetics of blood clotting and the structure, function and cellular production of blood-clotting and other proteins. 

Our Research

Precise control of the blood-clotting system is essential for maintenance of the circulation in all higher animals. Deficient function of this system can lead to fatal bleeding following even a minor injury, whereas overactivity of this system can produce unwanted blood clots, resulting in blockages to critical blood vessels, as occurs in such diseases as heart attack and stroke.

We study the genetics of blood clotting, the structure and function of key blood clotting proteins, and the processes regulating the cellular secretion of blood clotting and other proteins.

David Ginsburg, M.D.

Research Professor, U-M Life Sciences Institute
James V. Neel Distinguished University Professor and Warner-Lambert/Parke-Davis Professor, Departments of Internal Medicine, Human Genetics and Pediatrics, U-M Medical School

Publication Highlights

Deep mutational scanning and massively parallel kinetics of plasminogen activator inhibitor-1 functional stability to probe its latency transition

Haynes LM, Huttinger ZM, Yee A, Kretz CA, Siemieniak DR, Lawrence DA, Ginsburg D, J Biol Chem (2022) 

Genome-scale CRISPR screening for modifiers of cellular LDL uptake

Emmer BT, Sherman EJ, Lascuna PJ, Graham SE, Willer CJ, Ginsburg D, PLoS Genetics (2021)

The in vivo endothelial cell translatome is highly heterogeneous across vascular beds

Cleuren ACA, van der Ent MA, Jiang H, Hunker KL, Yee A, Siemieniak DR, Molema G, Aird WC, Ganesh SK, Ginsburg D, Proc Natl Acad Sci U S A  (2019)

The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9

Emmer BT, Hesketh GG, Kotnik E, Tang VT, Lascuna PJ, Xiang J, Gingras AC, Chen XW, Ginsburg D, Elife (2018) 

Whole exome sequencing of ENU-induced thrombosis modifier mutations in the mouse

Tomberg K, Westrick RJ, Kotnik EN, Cleuren AC, Siemieniak DR, Zhu G, Saunders TL, Ginsburg D, PLoS Genetics (2018)

Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo

Khoriaty R, Hesketh GG, Bernard A, Weyand AC, Mellacheruvu D, Zhu G, Hoenerhoff MJ, McGee B, Everett L, Adams EJ, Zhang B, Saunders TL, Nesvizhskii AI, Klionsky DJ, Shavit JA, Gingras AC, Ginsburg D, Proc Natl Acad Sci U S A (2018)

Murine coagulation factor VIII is synthesized in endothelial cells

Everett LA, Cleuren AC, Khoriaty R, Ginsburg DBlood (2014)

Plasminogen is a critical host pathogenicity factor for group A streptococcal infection

Sun H, Ringdahl U, Homeister JW, Fay WP… Ginsburg D, Science (2004)

Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex

Zhang B, Cunningham MA, Nichols WC, Bernat JA, Seligsohn U, Pipe SW, McVey JH, Schulte-Overberg U, de Bosch NB, Ruiz-Saez A, White GC, Tuddenham EG, Kaufman RJ, Ginsburg , Nat Genet (2003)

Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura

Levy GG, Nichols WC, Lian EC… Ginsburg D*, Tsai HM, Nature (2001)

Room 5314
Life Sciences Institute
Mary Sue Coleman Hall
210 Washtenaw Avenue
Ann Arbor, MI 48109-2216