Herman Fung lab

We use structural and cell biology approaches to study the spatial organization of chromatin and how its dynamic structure underlies organismal development.

Our Research

The 3D structure of chromatin strongly influences a cell's gene program, fate and function. Our lab uses cryo-electron tomography (cryo-ET) to visualize native chromatin inside cells and quantitatively analyze their structural changes during cellular differentiation. Combined with single-particle cryo-electron microscopy (cryo-EM) and biophysical analysis of key chromatin complexes, we seek to uncover the molecular basis of gene activation and repression central to development.

Keeping in step with biology, we develop correlative imaging and labelling approaches to enable multi-scale targeted studies of cellular processes by light and electron microscopy.

Join our team! 

We have postdoc and research specialist positions available. Apply here for the research specialist position or contact us if you have a passion for cellular imaging, structural and/or computational biology. 

Herman with a cryo-FIB-SEM instrument

Herman Fung, Ph.D.

Research Assistant Professor, U-M Life Sciences Institute
Assistant Professor of Cell and Developmental Biology, U-M Medical School
Assistant Professor of Biological Chemistry, U-M Medical School

Publication Highlights

Genetically encoded multimeric tags for subcellular protein localization in cryo-EM

Fung HKH*, Hayashi Y*, Salo VT*, Babenko A, Zagoriy I, Brunner A, Ellenberg J, Müller CW, Cuylen-Haering S, Mahamid J, Nature Methods (2023)

Structural basis of DNA packaging by a ring-type ATPase from an archetypal viral system

Fung HKH, Grimes S, Huet A, Duda RL, Chechik M, Gault J, Robinson CV, Hendrix RW, Jardine PJ, Conway JF, Baumann CG, Antson AA, Nucleic Acids Research (2022)

Mechanism of RNA polymerase I selection by transcription factor UAF.

Baudin F*, Murciano B*, Fung HKH*, Fromm SA*, Mattei S, Mahamid J, Müller CW, Science Advances (2022)

A modular platform for automated cryo-FIB workflows

Klumpe S*, Fung HKH*, Goetz SK*, Zagoriy I, Hampoelz B, Zhang X, Erdmann PS, Baumbach J, Müller CW, Beck M, Plitzko JM, Mahamid J, Elife (2021)

*Equal contribution

Herman Fung
Department of Cellular & Developmental Biology, Michigan Medicine
Life Sciences Institute
Mary Sue Coleman Hall
210 Washtenaw Avenue
Ann Arbor, MI 48109-2216