David Sherman Lab

We harness the power of chemistry that has evolved inside of microorganisms to pioneer new antibiotics, anti-cancer drugs and other medicines.

Our Research

Composed of a dynamic, interdisciplinary team of scientists, the Sherman laboratory studies the biosynthesis of natural products from microbes that include cyanobacteria, actinomycetes, and myxobacteria. We are inspired by natural products from both terrestrial and marine organisms and seek to better understand their origins using a set of tools that includes molecular biology, genetics, biochemistry, structural biology, and bioorganic chemistry.

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David Sherman, Ph.D.

Research Professor, U-M Life Sciences Institute
Hans W. Vahlteich Professor of Medicinal Chemistry, U-M College of Pharmacy
Professor of Microbiology and Immunology, U-M Medical School
Professor of Chemistry, College of Literature, Science, and the Arts
(734) 764-0030
davidhs@umich.edu
Full Profile
Research
Lab Members
Publications

News

Diving into science diplomacy

Graduate student Amy Fraley recently joined faculty member David Sherman on his latest expedition in Cuba, where strict barriers have prevented access for nearly 60 years.

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Publication Highlights

Engineering sequence and selectivity of late-stage C-H oxidation in the MycG iterative cytochrome P450

Iizaka Y, Arai R, Takahashi A, Ito M, Sakai M, Fukumoto A, Sherman DH, Anzai Y, J Ind Microbiol Biotechnol (2022)

Recent advances in hapalindole-type cyanobacterial alkaloids: biosynthesis, synthesis, and biological activity

Hohlman RM, Sherman DH, Nat Prod Rep (2021)

Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida

Breiner-Goldstein E, Eyal Z, Matzov D, Halfon Y, Cimicata G, Baum M, Rokney A, Ezernitchi AV, Lowell AN, Schmidt JJ, Rozenberg H, Zimmerman E, Bashan A, Valinsky L, Anzai Y, Sherman DH, Yonath A, Nucleic Acids Res (2021)

Biosynthetic cyclization catalysts for the assembly of peptide and polyketide natural products

Adrover-Castellano ML, Schmidt JJ, Sherman DH, ChemCatChem (2021)

Structural diversification of hapalindole and fischerindole natural products via cascade biocatalysis

Hohlman RM, Newmister SA, Sanders JN, Khatri Y, Li S, Keramati NR, Lowell AN, Houk KN, Sherman DH, ACS Catal (2021)

Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase

Kalkreuter E, Bingham KS, Keeler AM, Lowell AN, Schmidt JJ, Sherman DH, Williams GJ, Nat Commun (2021)

An overview of the cytochrome P450 enzymes that catalyze the same-site multistep oxidation reactions in biotechnologically relevant selected actinomycete strains

Iizaka Y, Sherman DH, Anzai Y, Appl Microbiol Biotechnol (2021)

Molecular basis of iterative C─H oxidation by TamI, a multifunctional P450 monooxygenase from the tirandamycin biosynthetic pathway

Newmister SA, Kinshuk RS, Espinoza RV, Haatveit KC, Khatri Y, Martini RM, Garcia-Borràs M, Podust LM, Houk KN, Sherman DH, ACS Catal (2020)

Co-cultivation of microbial sub-communities in microfluidic droplets facilitates high-resolution genomic dissection of microbial 'dark matter'

Tan JY, Wang S, Dick GJ, Young VB, Sherman DH, Burns MA, Lin XN, Integr Biol (Camb) (2020)

Computational-based mechanistic study and engineering of cytochrome P450 MycG for selective oxidation of 16-membered macrolide antibiotics

Yang S, DeMars, Grandner JM, Olson NM, Anzai Y, Sherman DH, Houk KN, J Am Chem Soc (2020)

View All Publications on PubMed

Quick Links

Natural Products Discovery Core
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Contact Us

Adminstrative Assistant Kate Godwin
(734) 764-0030
Life Sciences Institute
Mary Sue Coleman Hall
210 Washtenaw Avenue
Ann Arbor, MI 48109-2216
ktgdwn@umich.edu

Diving for Discovery

Pharmaceutical Discovery from Cyanobacteria at the U-M Biological Station