Tzumin Lee Lab

We develop tools that track and tailor cell lineages to answer important questions about brain development, neuronal evolution and neural regeneration.

Our Research

Complex brains have evolved to produce many diverse neuron types, yet the fundamental mechanisms of how diversity emerges during development remains largely elusive. New technologies allow us to infer developmental trajectory from single-cell sequencing data. To resolve the underlying cell-fating mechanisms, however, we need to pinpoint where and when a particular cell fate is established. To do this, we need sophisticated genetic tools to map the cell’s lineage.

The Lee lab uses both invertebrate and vertebrate model systems to study neuronal lineage development and fating mechanisms. Ultimately, we aim to tailor neuronal lineages to engineer neural networks with desired functions and to improve cell therapy for neurodegenerative diseases.

Tzumin Lee

Tzumin Lee, M.D., Ph.D.

Peter D. Meister Professor of the Life Sciences, Life Sciences Institute
Professor of Molecular, Cellular, and Developmental Biology, College of Literature, Science, and the Arts
Investigator, Howard Hughes Medical Institute

Publication Highlights

TEMPO enables sequential genetic labeling and manipulation of vertebrate cell lineages

Espinosa-Medina I, Feliciano D, Belmonte-Mateos C, Miyares RL, Garcia-Marques J, Foster B, Lindo S, Pujades C, Koyama M, Lee T, Neuron (2022)

Hormone controlled changes in the differentiation state of post-mitotic neurons

Lai Y-W, Miyares RL, Liu L-Y, Chu S-Y, Lee T*, Yu H-H* Current Biology (2022)

A programmable sequence of reporters for lineage analysis

Garcia-Marques J, Espinosa-Medina I, Ku Kai-Yuan, Yang C-P, Koyama M, Yu HH,  Lee T, Nature Neuroscience (2020)

Enhanced Golic+: Highly effective CRISPR gene targeting and transgene HACKing in Drosophila

Chen H-M, Yao X, Ren Q, Chang C-C, Liu L-Y, Miyares RL, Lee T, Development (2020)

Conservation and divergence of related neuronal lineages in the Drosophila central brain

Lee Y-J, Yang C-P, Miyares RL, Huang Y-F, He Y, Ren Q, Chen H-M, Kawase T, Otsuna H, Sugino K, Aso Y, Ito K, Lee T, eLife (2020)

Life Sciences Institute
Mary Sue Coleman Hall
210 Washtenaw Avenue
Ann Arbor, MI 48109-2216