We seek to understand how membrane-enclosed structures within our cells perform their specific jobs to maintain cell health. We are particularly interested in lysosomes, which not only play an important role in cellular 'waste management,' but also  serve as a key decision-making center controlling cellular growth and survival. Loss of these functions can lead to wide range of diseases, including cancer and cardiovascular disorders.

Our lab combines state-of-the-art cryo-electron tomography approaches with biochemical and cell biological methods to elucidate how lysosomes perform their functions, how they get repaired when damaged and how they communicate with other organelles to maintain cell health.