Carole Parent Lab

We seek to understand how cells detect and respond to external chemotactic signals to shed light on inflammation and cancer metastasis.

Our Research

Our lab works to understand how cells detect and respond to external chemotactic signals that are detected by GPCRs, and, in particular, how the spatial and temporal relay of chemotactic signals between cells impact single and group cell migration in the context of inflammation and cancer metastasis.

Carole Parent, Ph.D.

Research Professor, U-M Life Sciences Institute

Raymond and Lynne Ruddon Professor of Cancer Biology and Pharmacology, U-M Medical School

Professor of Cell and Developmental Biology, U-M Medical School

parentc@umich.edu

Publication Highlights

Extracellular vesicles direct migration by synthesizing and releasing chemotactic signals

Kriebel PW, Majumdar R, Jenkins LM, Senoo H, Wang W, Ammu S, Chen S, Narayan K, Iijima M, Parent CA, J Cell Biol (2018)

Cell motility in cancer invasion and metastasis: insights from simple model organisms

Stuelten CH, Parent CA, Montell DJ, Nat Rev Cancer (2018)

Adenylyl cyclase A mRNA localized at the back of cells is actively translated in live chemotaxing Dictyostelium

Wang W, Chen S, Das S, Losert W, Parent CA, J Cell Sci (2018)

Modeling neutrophil migration in dynamic chemoattractant gradients: assessing the role of exosomes during signal relay

Szatmary AC, Nossal R, Parent CA, Majumdar R, Mol Biol Cell (2017)

Exosomes mediate LTB4 release during neutrophil chemotaxis

Majumdar R, Tavakoli Tameh A, Parent CA, PLoS Biol (2016)

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

Lämmermann T, Afonso PV, Angermann BR, Wang JM, Kastenmüller W, Parent CA, Germain RN, Nature (2013)

LTB4 is a signal-relay molecule during neutrophil chemotaxis

Afonso PV, Janka-Junttila M, Lee YJ, McCann CP, Oliver CM, Aamer KA, Losert W, Cicerone MT, Parent CA, Dev Cell (2012)

mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion

Liu L, Das S, Losert W, Parent CA, Dev Cell (2010)

Collective cell migration requires vesicular trafficking for chemoattractant delivery at the trailing edge

Kriebel PW, Barr VA, Rericha EC, Zhang G, Parent CA, J Cell Biol (2008)

Adenylyl cyclase localization regulates streaming during chemotaxis

Kriebel PW, Barr VA, Parent CA, Cell (2003)

View All Publications on PubMed