Carole Parent Lab

We seek to understand how cells detect and respond to external chemotactic signals to shed light on inflammation and cancer metastasis.

Our Research

Our lab works to understand how cells detect and respond to external chemotactic signals that are detected by GPCRs, and, in particular, how the spatial and temporal relay of chemotactic signals between cells impact single and group cell migration in the context of inflammation and cancer metastasis.

Carole Parent, Ph.D.

Research Professor, U-M Life Sciences Institute
Raymond and Lynne Ruddon Professor of Cancer Biology and Pharmacology, U-M Medical School
Professor of Cell and Developmental Biology, U-M Medical School
Faculty Director, Michigan Pioneer Fellows

Publication Highlights

Extracellular vesicles direct migration by synthesizing and releasing chemotactic signals

Kriebel PW, Majumdar R, Jenkins LM, Senoo H, Wang W, Ammu S, Chen S, Narayan K, Iijima M, Parent CA, J Cell Biol (2018)

Cell motility in cancer invasion and metastasis: insights from simple model organisms

Stuelten CH, Parent CA, Montell DJ, Nat Rev Cancer (2018)

Exosomes mediate LTB4 release during neutrophil chemotaxis

Majumdar R, Tavakoli Tameh A, Parent CA, PLoS Biol (2016)

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

Lämmermann T, Afonso PV, Angermann BR, Wang JM, Kastenmüller W, Parent CA, Germain RN, Nature (2013)

LTB4 is a signal-relay molecule during neutrophil chemotaxis

Afonso PV, Janka-Junttila M, Lee YJ, McCann CP, Oliver CM, Aamer KA, Losert W, Cicerone MT, Parent CA, Dev Cell (2012)

Collective cell migration requires vesicular trafficking for chemoattractant delivery at the trailing edge

Kriebel PW, Barr VA, Rericha EC, Zhang G, Parent CA, J Cell Biol (2008)

Parent Lab

Room 4382
Life Sciences Institute
Mary Sue Coleman Hall
210 Washtenaw Avenue
Ann Arbor, MI 48109-2216