Bing Ye Lab
We investigate neuronal development and defects that lead to brain disorders, such as the dysregulated gene expression seen in Down syndrome.
Our Research
The focus of our research is to address:
- how neuronal development contributes to the assembly and function of the nervous system
- how defects in this process lead to brain disorders
On neuronal development, we are interested in how neurons develop dendrites and axons into distinct subcellular compartments and how experience interacts with the genome to shape the nervous system.
On brain disorders, we investigate the role of dysregulated expression levels of genes (e.g., in Down syndrome). We use both Drosophila and mouse models in our research and take a multi-disciplinary approach that include genetics, cell biology, developmental biology, biochemistry, advanced imaging (for neuronal structures and activity), electrophysiology, computation and behavioral studies.
