Bing Ye Lab

We investigate neuronal development and defects that lead to brain disorders, such as the dysregulated gene expression seen in Down syndrome.

Our Research

The focus of our research is to address:

  1. how neuronal development contributes to the assembly and function of the nervous system
  2. how defects in this process lead to brain disorders

On neuronal development, we are interested in how neurons develop dendrites and axons into distinct subcellular compartments and how experience interacts with the genome to shape the nervous system.

On brain disorders, we investigate the role of dysregulated expression levels of genes (e.g., in Down syndrome). We use both Drosophila and mouse models in our research and take a multi-disciplinary approach that include genetics, cell biology, developmental biology, biochemistry, advanced imaging (for neuronal structures and activity), electrophysiology, computation and behavioral studies.

Bing Ye

Bing Ye, Ph.D.

Burton L. Baker Collegiate Professor of the Life Sciences
Research Professor, U-M Life Sciences Institute
Professor of Cell and Developmental Biology, U-M Medical School
Director, Perrigo Undergraduate Summer Fellowship Program, U-M Life Sciences Institute

Publication Highlights

DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse models

Liu H, Caballero-Florán RN, Hergenreder T, Yang T, Hull JM, Pan G, Li R, Veling MW, Isom LL, Kwan KY, Huang ZJ, Fuerst PG, Jenkins PM, Ye B, PLoS Biol (2023)

LabGym: Quantification of user-defined animal behaviors 1 using learning-based holistic assessment

 Hu Y, Ferrario CR, Maitland AD, Ionides RB, Ghimire A, Watson B, Iwasaki K, White H, Xi Y, Zhou J, Ye B, Cell Reports Methods (2023)

A neural basis for categorizing sensory stimuli to enhance decision accuracy

Hu Y, Wang C, Yang L, Pan G, Liu H, Yu G, Ye B, Current Biology (2020)

isoTarget: A genetic method for analyzing the functional diversity of splicing isoforms in vivo

Liu H, Pizzano S, Li R, Zhao W, Veling MW, Hu Y, Yang L, Ye B, Cell Reports (2020)

Serotonergic Modulation Enables Pathway-Specific Plasticity in a Developing Sensory Circuit in Drosophila

Kaneko T, Macara AM, Li R, Hu Y, Iwasaki K, Dunnings Z, Firestone E, Horvatic S, Guntur A, Shafer OT, Yang CH, Zhou J, Ye B, Neuron (2017)

The Krüppel-Like Factor Dar1 Determines Multipolar Neuron Morphology

Wang X, Zhang MW, Kim JH, Macara AM, Sterne G, Yang T, Ye B, J Neurosci (2015)

Trim9 regulates activity-dependent fine-scale topography in Drosophila

Yang L, Li R, Kaneko T, Takle K, Morikawa RK, Essex L, Wang X, Zhou J, Emoto K, Xiang Y, Ye B, Curr Biol (2014)

GM130 is required for compartmental organization of dendritic Golgi outposts

Zhou W, Chang J, Wang X, Savelieff MG, Zhao Y, Ke S, Ye B, Curr Biol (2014)

Room 5403
Life Sciences Institute
Mary Sue Coleman Hall
210 Washtenaw Avenue
Ann Arbor, MI 48109-2216