Daniel Klionsky Lab

We investigate how cells respond to stress conditions through autophagy, and the broader implications for human physiology and disease — including in cancer and neurodegenerative disorders.

Our Research

The cells of higher organisms have an internal mechanism for chewing up and recycling parts of themselves, particularly in times of stress. 

This process, called autophagy (literally "self-eating") is implicated in many aspects of human physiology and disease, including cancer, neurodegenerative conditions like Parkinson's and Alzheimer's diseases, cardiomyopathy, diabetes and other metabolic disorders.

Daniel Klionsky, Ph.D.

Research Professor, Life Sciences Institute
Alexander G. Ruthven Professor of Life Sciences, Department of Molecular, Cellular & Developmental Biology, U-M College of Literature, Science, and the Arts

Publication Highlights

Dimerization-dependent membrane tethering by Atg23 is essential for yeast autophagy

Hawkins WD, Leary KA, Andhare D, Popelka H, Klionsky DJ, Ragusa MJ, Cell Rep (2022)

Autophagy regulation by alternative spliced isoforms and implications in diseases

González-Rodríguez PD, Klionsky DJ, Joseph B, Nat Comm (2022)

Membrane binding and homodimerization of Atg16 via two distinct protein regions is essential for autophagy in yeast

Popelka H, Reinhart EF, Metur SP, Leary KA, Ragusa MJ, Klionsky DJ, Mol Biol (2021)

Downregulation of autophagy by Met30-mediated Atg9 ubiquitination

Feng Y, Ariosa A, Yang Y., Hu Z, Dengjel J, and Klionsky DJ, PNAS (2021)  

The transcription factor Spt4-Spt5 complex regulates the expression of ATG8 and ATG41

Wen X, Gatica D, Yin A, Hu A, Dengjel J, Klionsky DJ, Autophagy (2020)

Psp2, a novel regulator of autophagy that promotes autophagy-related protein translation

Yin Z, Liu X, Ariosa S, Huang H, Jin M, Karbstein K, Klionsky DJ, Cell Res (2019)

Dhh1 promotes autophagy-related protein translation during nitrogen starvation

Liu X, Yao Z, Jin M, Namkoong S, Yin A,  Lee JH, Klionsky DJ, PLoS Biol (2019)

The Pat1-Lsm complex stabilizes ATG mRNA during nitrogen starvation-induced autophagy

Gatica D, Hu G, Liu X, Zhang N, Williamson PR, Klionsky DJ, Mol Cell (2019)

Cargo recognition and degradation by selective autophagy

Gatica D, Lahiri V, Klionsky DJ, Nat Cell Biol (2018)

The exoribonuclease Xrn1 is a post-transcriptional regulator of autophagy

Delorme-Axford E, Abernathy E, Lennemann NJ, Bernard A, Ariosa A, Coyne CB, Kirkegaard K, Klionsky DJ, Autophagy (2018)

Klionsky Lab

Room 6314
Life Sciences Institute
Mary Sue Coleman Hall
210 Washtenaw Avenue
Ann Arbor, MI 48109-2216
I view my teaching the same way I do my research: it's an ongoing experiment.
Daniel Klionsky