Our research program focuses on the structural biology and biophysics underlying microtubule-based intracellular transport through cryo-electron microscopy, single-molecule fluorescence and biochemistry.
Overarching questions of the lab:
- How is specificity determined between motor proteins and cargo?
- How are the activities of motor proteins regulated?
- How do pathogens hijack the microtubule transport machinery?
Along the way, we are leveraging artificial intelligence and cloud computing to improve cryo-electron microscopy data collection and analysis to streamline structure determination.