Lois Weisman Lab

We seek to understand essential cellular processes — using cultured neurons, cell lines and yeast — in order to shed new light on neurodegeneration, cancer and other diseases.

Our Research

The Weisman lab uses cultured neurons, cell lines and yeast to study neurodegeneration and cancer, with the goal of determining the mechanisms of myosin V based transport and phosphoinositide signaling. The ultimate goal is to develop novel therapies for relevant diseases.

Our group uses aspects of biochemistry, molecular biology, cell biology, genetics and developmental biology to discover how cells function.

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Lois Weisman, Ph.D.

Sarah Winans Newman Collegiate Professor in the Life Sciences

Research Professor, U-M Life Science Institute

Professor, Department of Cell & Developmental Biology, U-M Medical School

(734) 647-2539

lweisman@umich.edu

Full Profile

Research

Lab Members

Publications

Publication Highlights

Cargo release from myosin V requires the convergence of parallel pathways that phosphorylate and ubiquitylate the cargo adaptor

Wong S, Hepowit NL, Port SA, Yau RG, Peng Y, Azad N, Habib A, Harpaz N, Schuldiner M, Hughson FM, MacGurn HA, Weisman LS, Current Biol (2020)

Roles for a lipid phosphatase in the activation of its opposing lipid kinase

Strunk, B.S, Steinfeld, N, Lee, S., Jin, N., Akemann, C., MacGurn, J.A, Mapp, A.K., Weisman, L.S, Roles for a lipid phosphatase in the activation of its opposing lipid kinase.” Mol Biol Cell (2020)

Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling

Singla A, Fedoseienko A, Giridharan SSP, Overlee BL, Lopez A, Jia D, Song J, Huff-Hardy K, Weisman L, Burstein E, Billadeau DD, Nature Communications (2019)

Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein

Al-Ramahi I, Giridharan SSP, Chen YC, Patnaik S, Safren N, Hasegawa J, de Haro M, Wagner Gee AK, Titus SA, Jeong H, Clarke J, Krainc D, Zheng W, Irvine RF, Barmada S, Ferrer M, Southall N, Weisman LS, Botas J, Marugan JJ, Elife (2017)

Early protection to stress mediated by CDK-dependent PI3,5P2 signaling from the vacuole/lysosome

Jin N, Jin Y, Weisman LS, J Cell Biol (2017)

Spatial regulation of organelle release from myosin V transport by p21-activated kinases

Yau RGW*, Wong S*, Weisman LS, J Cell Biol (2017)

View All Publications on PubMed