HIV’s route to infection is more flexible than previously believed, new U-M study finds
LSI researchers uncovered unexpected details of the process that HIV uses to hijack cells’ transportation systems. The new study also offers a new system for further investigations into viral infection.
Incubator for Innovation
A new crop of faculty are finding optimal growth conditions in the LSI’s interdisciplinary environment
Study uncovers how genetic mutations linked to childhood neurodegeneration cause essential cellular machine to break down
LSI researchers have determined how specific genetic mutations found in children with neurodegenerative diseases disrupt essential cellular processes.
New study reveals how shedding DNA allows pro-inflammatory immune cells to quiet inflammation
The immune system’s first responders can reverse their own inflammatory response by shedding tiny pieces of their identity, according to a new study from the LSI.
LSI faculty will explore new approaches to developing antiparasitics and preventing kidney disorders, with philanthropic funding
Two projects have been awarded Klatskin-Sutker Discovery funding, marking the fund’s ninth and tenth projects to receive support from the endowed fund.
Arsenal Bridge Ventures invests in U-M startup Courage Therapeutics to advance innovative weight regulation drugs
Courage Therapeutics, a University of Michigan spinout company developing medications for eating disorders and obesity, announced a significant investment from Arsenal Bridge Ventures. This seed investment will enable Courage Therapeutics to complete essential testing and development to advance its drug candidates to clinical trials.
New view of cellular delivery trucks reveals unexpected hitch
LSI researchers have uncovered an unexpected tactic that one class of proteins uses to ferry cargo to its cellular destination, offering understanding of a process that is fundamental to cell survival.
Variations in temperature and diet can affect this rodent’s ability to survive venomous snake bites
New research reveals that the power of a snake’s venom to incapacitate its prey may depend on more than just its potency, or even the prey’s tolerance for the toxin.
Broadening the Research Lens
In the Aspirnaut Program at U-M, high school scientists see the full picture of their futures in STEM
Perspectives: 'Amazingly Fertile Ground'
Two LSI faculty members discuss how their long-standing cross-discipline collaboration has helped their research flourish
Core Strength
The experts in the LSI’s cores don’t just advance research projects — they pioneer new science
With new book, LSI professor wants to help researchers navigate genetic models for studying Down syndrome
Bing Ye has edited and co-authored a new book that he hopes will help current researchers and newcomers to the field capitalize on the variety of tools and systems available for studying Down syndrome.
Life Sciences Institute kicks off Look to Michigan Campaign with three gifts supporting faculty and students
The U-M Life Sciences Institute will strengthen its support for graduate students and provide new funds to advance faculty members’ innovative research, thanks to three generous gifts.
Researchers have determined how mice cough, and it matters for humans
U-M researchers have mapped the circuit that controls cough in mice — a model organism that was not previously known to exhibit this behavior.
New view of a biological antibiotic assembly line reveals how machinery could be exploited to build better antibiotics
LSI researchers have determined how the final machine in a biological assembly line completes the production of an important group of antibiotics, opening the door the door to tinkering with the machinery to produce new antibiotics.
New research in mice demonstrates potential for increasing effectiveness of popular diabetes and weight-loss drugs
Adjusting the melanocortin system makes mice more sensitive to GLP-1 drugs and other hormones that affect feeding behavior, according to a new study from the LSI. The researchers are optimistic that the results will translate well to patients.
With philanthropic funding, U-M researcher will probe therapeutic potential of a previously overlooked protein
A structural biologist at the University of Michigan Life Sciences Institute aims to unlock the therapeutic potential of one subtype of ion channels, with support from the Klatskin-Sutker Discovery Fund.
Meet the new U-M faculty member exploring DNA's dynamic organization in 3D
Assistant Professor Herman Fung discusses the development of his scientific career and plans for his new lab at U-M.
Research highlight: Chemical tool illuminates pathways used by dopamine, opioids and other neuronal signals
LSI researchers have developed a chemical tool to detect how signaling molecules travel within the brain to reach and interact with GPCRs. The tool can detect molecules across brain regions without sacrificing spatial resolution.
New understanding of immune cells’ role in driving liver disease points to a potential therapeutic target for NASH
A new study from the LSI reveals how macrophages may be driving, rather than combatting, liver disease in mice.
Researchers uncover protein responsible for cold sensation
LSI researchers have identified the protein that enables mammals to sense cold, filling a long-standing knowledge gap in the field of sensory biology.
Researchers open new leads in anti-HIV drug development, using a compound found in nature
A team of U-M researchers has successfully modified a naturally occurring chemical compound in the lab, resulting in advanced lead compounds with anti-HIV activity.
A basic biological question leads to the first FDA-approved treatment for rare blood disorder
The recently FDA-approved TAK-755 treatment for a rare but potentially lethal blood disorder arose from a fundamental biological question that piqued the interest of scientist in the Ginsburg lab at U-M.
Building on existing strengths, U-M launches expanded multidisciplinary fellowship program with 13 new fellows
Thirteen postdoctoral researchers are initiating novel, crossdisciplinary projects at U-M, with support from the Michigan Pioneer Fellows program.