Anna Mapp Lab

We use the tools of synthetic organic chemistry, biochemistry, and molecular biology to better understand how genes are regulated.

Our Research

The Mapp research group uses the tools of synthetic organic chemistry, biochemistry, and molecular biology to better understand how genes are regulated.

Projects in the group range from the development of new synthetic methods for preparing complex, optically active structures to manipulating genes in Saccharomyces cerevisiae (yeast) in order to identify key protein-protein interactions in gene activation.

Our group is multidisciplinary with students from the Medicinal Chemistry Program, Program in Chemical Biology, and the Department of Chemistry.

Lab Mission Statement

We believe that it is only through the unified commitment to and active involvement of each member that a diverse and inclusive environment for all can be created.

Anna Mapp, Ph.D.

Research Professor, U-M Life Sciences Institute
Associate Dean for Academic Programs and Initiatives, U-M Rackham Graduate School
Edwin Vedejs Collegiate Professor of Chemistry, U-M College of Literature, Science, and the Arts

Publication Highlights

TMPRSS2 inhibitor discovery facilitated through an in silico and biochemical screening platform

eiffer AL, Garlick JM, Wu Y, Wotring JW, Arora S, Harmata AS, Bochar DA, Stephenson CJ, Soellner MB, Sexton JZ, Brooks CL 3rd, Mapp AK, ACS Med Chem Lett (2023)

Allostery in the dynamic coactivator domain KIX occurs through minor conformational micro-states

Peiffer AL, Garlick JM, Joy ST, Mapp AK, Brooks CL 3rd, PLoS Comput Biol (2022)

Copper-mediated radiocyanation of unprotected amino acids and peptides

Sharninghausen LS, Preshlock S, Joy ST, Horikawa M, Shao X, Winton WP, Stauff J, Kaur T, Koeppe RA, Mapp AK, Scott PJH, Sanford MS, J Am Chem Soc (2022)

A dual-site inhibitor of CBP/p300 KIX is a selective and effective modulator of Myb

Joy ST, Henley MJ, De Salle SN, Beyersdorf MS, Vock IW, Huldin AJL, Mapp AK, J Am Chem Soc (2021)

Norstictic acid is a selective allosteric transcriptional regulator

Garlick JM, Sturlis SM, Bruno PA, Yates JA, Peiffer AL, Liu Y, Goo L, Bao L, De Salle SN, Tamayo-Castillo G, Brooks CL 3rd, Merajver SD, Mapp AK, J Am Chem Soc (2021)

Unexpected specificity within dynamic transcriptional protein-protein complexes

Henley MJ, Linhares BM, Morgan BS, Cierpicki T, Fierke CA, Mapp AK, Proc Natl Acad Sci (2020)

Room 4000
Life Sciences Institute
Mary Sue Coleman Hall
210 Washtenaw Avenue
Ann Arbor, MI 48109-2216
The Mapp Lab believes that it is only a diverse and inclusive multidisciplinary research culture that enables lab members to work to their highest potential, to advance our scientific objectives, and to develop the next generation of innovators, scientists, and leaders.