Ken Inoki Lab

We investigate the function and regulation of the mTOR signaling pathway to better understand its role in diabetes, aging and cancer.

Our Research

In response to growth factors and nutrients, the mechanistic target of rapamycin (mTOR), plays essential roles in stimulating a wide array of anabolic cellular processes, including protein synthesis, lipid biogenesis and nucleotide synthesis, which is crucial for cell growth and proliferation. Critically, dysregulation of the mTOR signaling pathway is known to be involved in the development of various human diseases, such as cancer and metabolic disorders.

Using biochemical and genetic approaches, we investigate the function and regulation of the mTOR signaling pathway and the role of mTOR signaling in human health problems.

Ken Inoki, M.D., Ph.D.

Roger C. Wiggins Collegiate Professor of the Life Sciences
Research Associate Professor, U-M Life Sciences Institute
Associate Professor, Division of Nephrology, Department of Internal Medicine, U-M Medical School
Associate Professor, Department of Molecular & Integrative Physiology, U-M Medical School

Publication Highlights

Nutrient-sensing mTORC1 and AMPK pathways in chronic kidney diseases.

Huynh C, Ryu J, Lee J, Inoki A, Inoki K, Nat Rev Nephrol (2023)

Amino acids enhance polyubiquitination of Rheb and its binding to mTORC1 by blocking lysosomal ATXN3 deubiquitinase activity

Yao Y, Hong S, Ikeda T, Mori H, MacDougald OA, Nada S, Okada M, Inoki K, Mol Cell (2020)

LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs

Hong S, Freeberg MA, Han T, Kamath A, Yao Y, Fukuda T, Suzuki T, Kim JK, Inoki K, Elife (2017)

Inhibition of AMPK catabolic action by GSK3

Suzuki T, Bridges D, Nakada D, Skiniotis G, Morrison SJ, Lin JD, Saltiel AR, Inoki K, Mol Cell (2013)

mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

Inoki K, Mori H, Wang J, Suzuki T, Hong S, Yoshida S, Blattner SM, Ikenoue T, Rüegg MA, Hall MN, Kwiatkowski DJ, Rastaldi MP, Huber TB, Kretzler M, Holzman LB, Wiggins RC, Guan KL, J Clin Invest (2011)

ER-associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity

Liu L, Inoki A, Fan K, Mao F, Shi G, Jin X, Zhao M, Ney G, Jones M, Sun S, Dou Y, Inoki K, Qi L, Li Q, Blood (2020)

Inoki Lab

Room 6183
Life Sciences Institute
Mary Sue Coleman Hall
210 Washtenaw Avenue
Ann Arbor, MI 48109-2216