43. Doyon, T. J; Skinner, K. C.; Yang, D.; Mallik, L.; Wymore, T.; Koutmos, M.; Zimmerman, P. M; Narayan, A. R. H. "Radical tropolone biosynthesis" ChemRxiv 2020, DOI:10.26434/chemrxiv.12780044.

42. Chakrabarty, S.; Wang, Y.; Perkins, J. C.; Narayan, A. R. H. "Scalable Biocatalytic C–H Oxyfunctionalization Reactions" Chem. Soc. Rev. 2020, DOI: 10.1039/d0cs00440e.

41. Chun, S. W. and Narayan, A. R. H. "Biocatalytic, Stereoselective Deuteration of α-Amino Acids and Methyl Esters" ACS Catal. 2020 DOI: 10.1021/acscatal.0c01885.

40. Lukowski, A. L.;‡ Liu, J.;‡ Bridwell-Rabb, J.;* Narayan, A. R. H.* "Structural basis for divergent C–H hydroxylation selectivity in two Rieske oxygenases" Nat. Commun. 2020 DOI: 10.1038/38/s41467-020-16729-0.

        ‡ These authors contributed equally.

39. Baker Dockrey, S. A. and Narayan, A. R. H. "Photocatalytic oxidative dearomatization of orcinaldehyde derivatives" Org. Lett. 2020 DOI: 10.1021.acs.orglett.0c01207.

38. Zetzsche, L. E. and Narayan, A. R. H. "Broadening the scope of biocatalytic C–C bond formation" Nat. Rev. Chem. 2020 DOI:10.1038/s41570-020-0191-2.

37. Rodríguez Benítez, A.; Dürr, S. L.; Narayan, A. R. H. "Radial scope: A new visualization tool for structure-data relationships" Trends in Chemistry 2020, DOI: https://doi.org/10.1016/j.trechm.2020.04.003.

36. Denomme, N.; Lukowski, A. L.; Hull, J. M.; Jameson, M. B.; Bouxa, A. A.; Narayan, A. R. H.; Isom, L. L. Neurosci. Lett. 2020, 724, 134853. DOI: j.neulet.2020.134853

35. Lukowski, A. L.; Mallik, L.; Hinze, M. E.; Carlson, B. M.; Ellinwood, D. C.; Pyser, J. B.; Koutmos, M. and Narayan, A. R. H. "Substrate promiscuity of a paralytic shellfish toxin amidinotransferase" ACS Chem. Biol. 202015, DOI: 10.1021/acschembio.9b00964.

34. Doyon, T. J.; Perkins, J. C.; Baker Dockrey, S. A.; Skinner, K. C.; Zimmerman, P. M.; Narayan, A. R. H. "Biocatalyst-Initiated ortho-Quinone Methide Formation and Derivatization" J. Am. Chem. Soc. 2019, 141, DOI: 10.1021/jacs.9b10474. (First disclosed on ChemRvixDOI: 10.26434/chemrxiv.7828769.v1)

33. Baker Dockrey, S. A.; Narayan, A. R. H. "Oxidative Dearomatization by Flavin-Dependent Monooxygenase." Trends in Chemistry 2019. DOI: 10.1016/j.trechm.2019.11.004.


32. Benítez Rodríguez, A.; Narayan, A. R. H. "Frontiers in Biocatalysis: Profiling Function across Sequence Space."ACS Cent. Sci. 2019, 5, 1747-1749. DOI: 10.1021/acscentsci.9b01112.


31. Pyser, J. B.; Baker Dockrey, S. A.; Benítez Rodríguez, A.; Joyce, L. A.; Wiscons, R. A.; Smith, J. L.; Narayan, A. R. H. "Stereodivergent, Chemoenzymatic Synthesis of Azaphilone Natural Products." J. Am. Chem. Soc. 2019141, 18551-18559. DOI: 10.1021/jacs.9b9385.

30. Tweedy, S. E.; Rodríguez Benítez, A.; Narayan, A. R. H.; Zimmerman, P. M.; Brooks, C. L., III and Wymore, T. "The hydroxyl radical coupled electron transfer mechanism of flavin-dependent hydroxylases." J. Phys. Chem. B  2019, 123, 38, 8065-8073. DOI: 10.1021/acs.jpcb.9b08178.

29. Baker Dockrey, S. A.; Suh, C.; Rodríguez Benítez, A.; Wymore, T.; Brooks III, C. L.; Narayan, A. R. H. “Positioning group-enabled biocatalytic oxidative dearomatization” ACS Cent. Sci. 2019, 5, 1010-1016. DOI:10.1021/acscentsci9b00163.

28. Doyon, T. J.; Narayan, A. R. H. "Synthetic Utility of One-Pot Chemoenzymatic Reaction Sequences" Synlett 2019 (cluster on biocatalysis). DOI: 10.1055/s-0037-1611848.

27. Lukowski, A. L.; Denomme, N.; Hinze, M. E.; Hall, S.; Isom, L. L.; Narayan, A. R. H. "Biocatalytic Detoxification of Paralytic Shellfish Toxins" ACS Chem. Biol. 201914, 941-948. DOI: 10.1021/acschembio.9b00123.

26. Aspuru-Guzik....Narayan, A. R. H....and many more. "Charting a course for chemistry" Nat. Chem. 2019, 11, 286-294. DOI: 10.1038/s41557-019-0236-7 (Editorial).

25. Chun, S. W.; Narayan, A. R. H. "Biocatalytic Synthesis of α-Amino Ketones" Synlett 2019, 30, 1269-1274. DOI: 10.1055/s-0037-1611755.

24. Narayan, A. R. H. “Enzymes trapped and zapped for use outside cells” Nature 2019567, 317-318. DOI: 10.1038/d41586-019-00761-2 (News & Views).

23. Baker Dockrey, S. A. and Narayan, A. R. H. “Flavin-dependent biocatalysts in synthesis” Tetrahedron 201975, 1115-1121. DOI: 10.1016/j.tet.2019.01.008 (Special Issue on Biocatalysis in Organic Synthesis).

22. Lukowski, A. L. and Narayan, A. R. H. “Natural voltage-gated sodium channel ligands: Biosynthesis and biology” ChemBioChem 2019, 20, 1231-1241. DOI: 10.1002/cbic.201800754 (Special Issue: New Talent).

21. Rodríguez Benítez, A.; Tweedy, S. E.; Baker Dockrey, S. A.; Lukowski, A. L.; Wymore, T.; Khare, D.; Brooks, C. L., III; Palfey, B. A.; Smith, J. L.; Narayan A. R. H. "Structural Basis for Selectivity in Flavin-Dependent Monooxygenase-Catalyzed Oxidative Dearomatization." ACS Catal. 2019, 9, 3633-3640. DOI: 10.1021/acscatal.8b04575.

Read our preprint. DOI:10.26434/chemrxiv.7297766.v1

20. Baker Dockrey, S. A.; Doyon, T. J.; Perkins, J. C.; Narayan, A. R. H. “Whole-cell biocatalysis platform for gram-scale oxidative dearomatization of phenols” Chem. Biol. Drug Des. 2019, 93, 1207-1213. DOI:10.1111/cbdd.13443.

19. Lukowski, A. L.; Ellinwood, D. C.; Hinze, M. E.; DeLuca, R. J.; Du Bois, J.; Hall, S.; Narayan, A. R. H. "C−H Hydroxylation in Paralytic Shellfish Toxin Biosynthesis" J. Am. Chem. Soc2018140, 11863-11869. DOI: 10.1021/jacs.8b08901.

18. Chun, S. W.; Hinze, M. E.; Skiba, M. A.; Narayan, A. R. H. "Chemistry of a unique polyketide-like synthase" J. Am. Chem. Soc. 2018140, 2430-2433. DOI: 10.1021/jacs.7b13297.

17. Baker Dockrey, S. A.; Lukowski, A. L.; Becker, M. R.; Narayan, A. R. H.  “Biocatalytic site- and enantioselective oxidative dearomatization of phenols” Nature Chem. 201810, 119-125. DOI: 10.1038/nchem.2879.

Mentored Publications

16. Gilbert, M. M.; DeMars, M. D.; Yang, S.; Grandner, J. M.; Wang, S.; Wang, H.; Narayan, A. R. H.; Sherman, D. H.; Houk, K. N.; Montgomery, J. "Synthesis of Diverse 11- and 12-Membered Macrolactones from a Common Linear Substrate Using a Single Biocatalyst” ACS Cent. Sci. 20173, 1304-1310. DOI: 10.1021/acscentsci.7b00450.

15. Narayan, A. R. H.; Jiménez-Osés, G.; Liu, P.; Negretti, S.; Zhao, W.; Ramabhadr, R. O.; Furan, L.; Li, Z.; Yang, Y.-F.; Gilbert, M.; Podust, L. M.; Montgomery, J.; Houk, K. N.; Sherman, D. H.  “Enzymatic Hydroxylation of an Unactivated Methylene C–H Bond Guided by Molecular Dynamics Simulations” Nature Chem. 20157, 653-660.

14. Dutta, S.; Whicher, J. R.; Hansen, D. A.; Hale, W. A.; Chemler, J. A.; Narayan, A. R. N.; Hakansson, K.; Sherman, D. H.; Smith, J. L.; Skiniotis, G. “Structure of a modular polyketide synthase” Nature 2014510, 512-517.

13. Whicher, J. R.; Dutta, S.; Hansen, D. A.; Hale, W. A.; Chemler, J. A.; Narayan, A. R. N.; Hakansson, K.; Sherman, D. H.; Smith, J. L.; Skiniotis, G. “Structural rearrangements of a PKS module during its catalytic cycle” Nature 2014510, 560-564.

12. Negretti, S.*; Narayan, A. R. H.*; Chiou, K. C.; Kells, P. M.; Stachowski, J. L.; Hansen, D. A.; Podust, L. M.; Montgomery, J.; Sherman, D. H. “Directing group-controlled regioselectivity in an enzymatic C-H bond oxygenation” J. Am. Chem. Soc. 2014136, 4901-4904. *Denotes equal contribution

11. Heller, S. T.; Kiho, T.; Narayan, A. R. H.; Sarpong, R. “Protic Solvent Mediated Cycloisomerization of Quinoline and Isoquinoline Propargylic Carbinols: Syntheses of (±)-3-Demethoxyerythratidinone and (±)-Cocculidine” Angew. Chem. Int. Ed. 201352, 11129-11133.

10. Hansen, D. H.; Rath, C. M.; Eisman, E. B.; Narayan, A. R. H.; Kittendorf, J. D.; Mortison, J. D.; Yoon, Y. J.; Sherman, D. H. “Biocatalytic Synthesis of Pikromycin, Methymycin, Neomethymycin, Novamethymycin, and Ketomethymycin” J. Am. Chem. Soc.2013135, 11232-11238.

9. Narayan, A. R. H.; Sherman, D. H. “Re-engineering nature’s catalysts” Science 2013339, 283-284.

8. Hardin Narayan, A. R.; Sarpong, R. "Indolizinones as Synthetic Scaffolds: Fundamental Reactivity and the Relay of Stereochemical Information" Org. Biomol. Chem. 201210, 70-78.

7. Hardin Narayan, A. R.; Sarpong, R. “Remarkable Facilitation of Hetero-Cycloisomerizations with Water and Other Polar Protic Solvents: Metal-Free Synthesis of Indolizines” Green Chem. 201010, 1556-1559.

6. Hardin Narayan, A. R.; Simmons, E. R.; Sarpong, R. “Synthetic strategies toward the cortistatin family of natural products” Eur. J. Org. Chem. 2010, 3553-3567.

5. Simmons, E. M.; Hardin, A. R.; Guo, X.; Sarpong, R. "Formal total synthesis of (±)-cortistatin A" Tetrahedron 201066, 4696-4700.

4. Simmons, E. M.; Hardin, A. R.; Guo, X.; Sarpong, R. “Rapid Construction of the Cortistatin Pentacyclic Core” Angew. Chem. Int. Ed. 200847, 6650 – 6653.

3. Hardin, A. R.; Sarpong, R. "Electronic Effects in the Pt-Catalyzed Cycloisomerization of Propargylic Esters: Synthesis of 2,3-Disubstituted Indolizines as a Mechanistic Probe" Org. Lett20079, 4547-4550.

2. Adams, J.; Hardin, A. R.; Vounatsos, F. “Microwave-Assisted Synthesis of New Polysubstituted Dienaminoesters and Their Cyclization to 3-Bromo-2(1H)-Pyridinones” J. Org. Chem. 200671, 9895-9898.

1. Hay, M.; Hardin, A. R.; Wolfe, J. P. “Palladium-Catalyzed Synthesis of Tetrahydrofurans from γ-Hydroxy Terminal Alkenes:  Scope, Limitations, and Stereoselectivity” J. Org. Chem. 200570, 3099-3107.