Chemical compound produced in nature effectively targets ‘undruggable’ proteins, new research finds
Researchers have demonstrated that a natural compound produced by lichens can block the activity of a protein that is central to the gene-activation process. The research, conducted in human-derived breast cancer cells, points to this protein as potential therapeutic target.
Klatskin-Sutker Discovery Fund award supports development of novel antivirals at the LSI
Researchers are advancing a novel approach to developing antivirals against SARS-CoV-2, with support from the LSI’s Klatskin-Sutker Discovery Fund
Research Highlight: New understanding of gene-activating complexes may offer ‘a way forward’ for drug discovery efforts
New research is challenging a long-held understanding of how two types of cellular proteins cooperate to activate genes. The findings improve the possibility of targeting these interactions with small-molecule drugs.
Balancing Autonomy and Community to Cultivate Tomorrow’s Scientific Leaders
In the Michigan Life Sciences Fellows program, May-Walt Fellow Brittany Morgan, Ph.D., has found a balance of independence and community that will serve her well as she prepares for her independent scientific career. Learn how this 'super postdoc' program is helping fellows get a step ahead in their early careers and developing the next generation of scientific leaders.
LSI Cubed funds new round of trainee-initiated, multi-lab research projects
Four teams of graduate students and postdoctoral fellows will soon launch their own cross-lab, interdisciplinary projects, with funding from the LSI Cubed program.
New research clarifies how ‘fuzzy’ proteins can be used to develop novel drugs
Researchers have determined how to target a class of proteins that have long been considered too “fuzzy” to target with small molecules, opening the door to new drug-discovery projects.
Scientists can now measure activity of key cancer cell-survival protein, an important step toward inhibiting it
Findings remove a barrier to developing potential therapies for cancer patients with poor prognoses.
Pure Science, Pure Michigan
In the last century, Michigan was a driving engine of America’s manufacturing economy. Today, programs like the Perrigo Undergraduate Fellowship at the LSI are helping to fuel a new knowledge-based economy in the state.
A transcription factor runs through it
How fly fishing can help explain a new frontier of drug discovery
U-M scientists develop a new strategy for inhibiting protein-protein interactions
Researchers blocked the dysregulated signaling associated with a 'master transcription factor,' which controls many different cellular decisions, without compromising its other biologically important functions.
LSI Researcher Honored for Significant Contribution to the Study of Proteins
Anna Mapp, Ph.D. has been awarded the 2015 Emil Thomas Kaiser Award from the Protein Society. The award recognizes a recent, highly significant contribution in applying chemistry to the study of proteins.