Lois Weisman researches the underlying causes of neurodegeneration and other neurological diseases, of which little is known. Her work focuses on myosin V based transport and phosphoinositide lipid signaling in yeast and neurons, with the overall goal of uncovering new, essential subcellular processes and to determine how these impact human physiology.
Currently, Weisman is pursuing research about the PI3,5P2 signaling pathway, which her lab found causes a severe neuropathy in people when there are even minor defects in the pathway. It was an unexpected discovery; now, she is focused on understanding how the pathway is regulated, what downstream effectors are regulated by PI3,5P2, and if defects in the pathway are a common cause of human disease. She hopes to find that upregulation of this pathway will show therapeutic promise.
In addition, Weisman is working on solving a second puzzle: how do organelles move to the correct place at the proper time? This directed organelle movement is critical during cell division and differentiation, and defects in the movement have wide-ranging effects, such as neurological disease and defects in pigmentation.
Prior to joining the faculty at the University of Michigan Life Sciences Institute, Weisman was a Professor of Biochemistry at the University of Iowa. Weisman is currently the Sarah Winans Newman Collegiate Professor in the Life Sciences.
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