Our research program focuses on the structural biology and biophysics underlying microtubule-based intracellular transport through the use of cryo-electron microscopy, single molecule TIRF, and biochemistry.
Overarching questions of the lab:
- How is specificity determined between motor proteins and cargo?
- How are the activities of multi-motor complexes regulated?
- What are the molecular consequences of neurodegenerative disease-causing mutations?
Along the way, we are also developing cloud computing tools for cryo-electron microscopy to facilitate its adoption and to remove barriers for new users.