Our Research

The M. Ohi lab's research interest focuses on dissecting the structural organization of large macromolecular machines. Our goal is to use structure as a springbord to understand function within the context of cells.

Our laboratory uses single particle cryo-electron microscopy (cryo-EM) in combination with biophysical, biochemical, and genetic approaches to structurally and functionally characterize biologically important but structurally challenging molecular machines. We have exciting projects studying the machinery involved in gene regulation, bacterial pathogenesis, and membrane remodeling proteins.