New insights into protein recycling pathways shed light on how the brain forms memories
Researchers have uncovered new details in the complex cellular mechanism that is central to the brain’s ability to learn and form memories.
Study uncovers how genetic mutations linked to childhood neurodegeneration cause essential cellular machine to break down
LSI researchers have determined how specific genetic mutations found in children with neurodegenerative diseases disrupt essential cellular processes.
New view of cellular delivery trucks reveals unexpected hitch
LSI researchers have uncovered an unexpected tactic that one class of proteins uses to ferry cargo to its cellular destination, offering understanding of a process that is fundamental to cell survival.
Broadening the Research Lens
In the Aspirnaut Program at U-M, high school scientists see the full picture of their futures in STEM
Researchers identify new route cellular proteins travel to help maintain a functioning neural network
Scientists have discovered a new pathway that ferries cellular proteins to the cell-to-cell connections that allow neurons to communicate with one another.
Mapping Cellular Traffic
LSI scientists explore the complex cellular supply chain, how it works and what happens when it's disrupted
Research Highlight: Scientists uncover unexpected function for an obscure enzyme, hinting at broader roles in multiple human disorders
An obscure enzyme that normally operates deep within cells is also playing an unexpected role close to the cell surface—and is even required for cell migration—according to new research from the Life Sciences Institute.
Cells rely on multiple controls to coordinate cargo delivery, new research shows
Researchers have uncovered a new twist in the complex process cells use to transport their molecular cargo.
Researchers identify new potential drug target for Huntington’s disease
New insights allowed researchers to ameliorate the effects of Huntington’s disease in a fruit fly model of the disease.
Newly identified protection mechanism serves as first responder to cellular stress
How a new type of rapid-response defense mechanism helps protect cells from environmental stress while giving slower, well-known protection systems time to act
Figuring out how motor proteins know where to drop off their cargo
A new study sheds new light on how the motor protein myosin V knows where to release a yeast vacuole, when transporting it from the mother cell into a new bud.
Unexpected link between organelles and the cell-division cycle
Studies using yeast genetics have provided new, fundamental insights into the cell-division cycle, researchers at the LSI reported.
Signaling lipids as potential target for neurological therapies
LSI researchers uncover information about a little-known signaling lipid pathway that unexpectedly plays critical roles in neuronal synapses in humans.
How organelles get to the right place at the right time
LSI researchers have discovered a key enzyme responsible for regulating the final step in the movement of organelles during cell division and differentiation.