Researchers identify a hormone from fat cells that reprogram the liver microenvironment and restrain tumor growth in mice
A hormone secreted by fat cells can restrain the growth of liver tumors in mice, according to a new study from the LSI. The findings offer a proof-of-concept for developing therapies against the most common form of liver cancer.
Researchers have discovered how a protein that is overproduced by fat cells in an obese state may be contributing to the demise of two immune cell types — and driving further metabolic disorders in the process
Researchers have created a high-resolution picture of the cells at work inside a key hub of metabolism — the liver — and how individual cell types are reprogrammed in disease.
Researchers have identified a hormone produced by the liver that tells the body to downshift its metabolism when it’s expending a lot of energy, revealing a potential target for treating metabolic disorders.
Fifteen researchers at the University of Michigan — including two from the Life Sciences Institute — have been named fellows of the American Association for the Advancement of Science, an honor bestowed upon AAAS members by their peers.
Scientists uncover a potential new role for long noncoding RNA in obesity and non-alcoholic fatty liver disease.
A team of researchers has developed a new system to measure how fat cells can be activated to burn energy.
Scientists identify a key driver of the progression to the most harmful form of fatty liver disease.
How a network of proteins and long noncoding RNA work together to push fat cells into fat-burning mode
An unexpected mechanism of glucose sensing in skeletal muscles contributes to the body’s overall regulation of blood sugar levels.
Identified: a pathway in the liver, controlled by a protein known as BAF60a, that contributes to the negative effects of a high-fat diet by stimulating the production of bile — which helps the body to absorb more cholesterol and other fats from the foods we eat.
Newly discovered hormone points to potential treatment for obesity, type 2 diabetes, fatty liver disease
LSI scientists have discovered how a previously unknown hormone serves as a messenger from fat cells to the liver and are investigating the potential of developing a new treatment for metabolic disorders.