Our Research
Precise control of the blood-clotting system is essential for maintenance of the circulation in all higher animals. Deficient function of this system can lead to fatal bleeding following even a minor injury, whereas overactivity of this system can produce unwanted blood clots, resulting in blockages to critical blood vessels, as occurs in such diseases as heart attack and stroke.
We study the molecular genetics of blood clotting, specifically von Willebrand factor, coagulation factor V and plasminogen activation.
David Ginsburg, M.D.
News
Sending one gene to pinch hit for its twin may offer possible treatment for a type of congenital anemia
A team of U-M researchers has found that two paralog genes — which can lead to two very different diseases — are functionally nearly identical. The findings indicate that one gene could be harnessed to help treat the disease associated with the other.
Pure Science, Pure Michigan
In the last century, Michigan was a driving engine of America’s manufacturing economy. Today, programs like the Perrigo Undergraduate Fellowship at the LSI are helping to fuel a new knowledge-based economy in the state.
Trapping PCSK9 to lower cholesterol
Targeting the transport mechanism for a destructive protein lowers blood cholesterol levels in mice.
Publication Highlights
Westrick RJ, Tomberg K, Siebert AE, Zhu G, Winn ME, Dobies SL, Manning SL, Brake MA, Cleuren AC, Hobbs LM, Mishack LM, Johnston AJ, Kotnik E, Siemieniak DR, Xu J, Li JZ, Saunders TL, Ginsburg D, Proc Natl Acad Sci U S A (2017)
Kretz CA, Dai M, Soylemez O, Yee A, Desch KC, Siemieniak D, Tomberg K, Kondrashov FA, Meng F, and D Ginsburg, Proc Natl Acad Sci U S A (2015)
Khoriaty R, Vasievich MP, Jones M, Everett L, Chase J, Tao J, Siemieniak D, Zhang B, Maillard I, Ginsburg D, Mol Cell Biol (2014)
Everett LA, Cleuren AC, Khoriaty R, Ginsburg D, Blood (2014)
Chen XW, Wang H, Bajaj K, Zhang P, Meng ZX, Ma D, Bai Y, Liu HH, Adams E, Baines A, Yu G, Sartor MA, Zhang B, Yi Z, Lin J, Young SG, Schekman R, Ginsburg D, Elife (2013).
Sun H, Ringdahl U, Homeister JW, Fay WP… Ginsburg D, Science (2004)
Zhang B, Cunningham MA, Nichols WC, Bernat JA, Seligsohn U, Pipe SW, McVey JH, Schulte-Overberg U, de Bosch NB, Ruiz-Saez A, White GC, Tuddenham EG, Kaufman RJ, Ginsburg , Nat Genet (2003)
evy GG, Nichols WC, Lian EC… Ginsburg D*, Tsai HM, Nature (2001)