Research
We integrate DNA sequence technology, algorithm development and clinical studies to explore the diversity of microbes in and on humans in health and disease.
The Segre lab focuses on the human microbiome, investigating both the transmission of hospital pathogens and the diversity of beneficial skin organisms, including bacteria, fungi and viruses. Segre’s research integrates DNA sequence technology, algorithm development and clinical studies to explore the diversity of microbes in and on humans in health and disease. Her skin microbiome studies span the human lifespan. Her research program characterizes variation across body sites to investigate the stereotypic manifestation of cutaneous disorders, such as childhood atopic dermatitis (eczema) with the goal of developing precision medicine treatments. Tracking the spread of antibiotic resistance in healthcare ecosystems, her current research focuses on the skin microbiome of aging Americans, particularly nursing home residents.