Our lab studies optogenetic technologies for protein detection and manipulation in living cells.
We are applying cutting-edge protein engineering methods, such as directed evolution, to improve the dynamic range and overall performance of light-sensitive proteins, and to harness them for detection and manipulation of important biochemical events. Our goal is to expand the optogenetics toolbox with widespread utility across multiple subfields of cell biology and neuroscience.
Wenjing Wang, Ph.D.
News
New tool improves scientists’ ability to manipulate cellular activities
A collaboration between two LSI labs has resulted in a new research tool for manipulating when and where cellular functions are activated, using the power of peptides.
Research Highlight: New tool can “SPOT” presence of opioids in individual cells, offering clearer picture of their activity
Researchers in the lab of Wenjing Wang, Ph.D., have designed a new chemical tool that can detect the presence of opioids at a cellular level.
New LSI faculty member is shedding light on how neurons function
The LSI's newest faculty member will use her protein engineering prowess to develop tools that can advance research across the fields of neuroscience and cell biology.
Publication Highlights
Shen J, Geng L, Li X, Emery C, Kroning K, Shingles G, Lee K, Heyden M, Li P, Wang W, Nature Methods (2022)
Kim MW, Wang W, Sanchez MI, Coukos R, von Zastrow M, Ting AY, Elife (2017)
Wang W, Nossoni Z, Berbasova T, Watson CT, Yapici I, Lee KS, Vasileiou C, Geiger JH, Borhan B, Science (2012)