Core Strength
The experts in the LSI’s cores don’t just advance research projects — they pioneer new science
New podcast explores the past, present and future of this Nobel Prize-winning technique
A new podcast and video series hosted by three faculty members from the University of Michigan, Cornell University and Columbia University explores what the future of cryo-EM will look like, while highlighting the career development and experiences of a wide range of experts in the field
Automated ‘pipeline’ improves access to advanced microscopy data
A new data-processing approach offers a simpler, faster path to data generated by cryo-electron microscopy instruments, removing a barrier to wider adoption of this powerful technique.
Study unveils the intricate way two proteins interact to promote cell movement and metastasis
Researchers have shed light on the molecular details of a protein-protein interaction that drives cell movement and cancer metastasis
Applications open for annual hands-on cryo-EM data workshop
The University of Michigan Life Sciences Institute will lead a five-day cryo-electron microscopy workshop in June to introduce participants to common image processing software packages.
Biosciences Initiative invests $45M in U-M research
Three ground-breaking LSI projects are among the University of Michigan projects to be funded in the first round of investments from the Biosciences Initiative.
Scientists get hands-on experience with cryo-EM data tools at U-M workshop
Thirty-five academic and industry scientists from across the country got hands-on experience with the latest cryo-electron microscopy image processing tools at a recent workshop led by the LSI.
LSI to lead four-day cryo-EM workshop
The LSI will lead a four-day cryo-electron microscopy workshop in June to introduce participants to common image processing software packages.
Video: What's cryo-EM and how is it revolutionizing biology?
U-M has one of the top cryo-EM labs in the country — learn more about how this technology is revolutionizing biology and how U-M is using it to study things like neurodegenerative diseases and bacterial infections.
Chilled proteins and 3-D images: The cryo-electron microscopy technology that just won a Nobel Prize
LSI faculty members Michael Cianfrocco and Melanie Ohi explain the technology that won the 2017 Nobel Prize for Chemistry.
Springboard to 'Science': Students' leap into cryo-EM program leads to high-impact findings
How two U-M graduate students came to co-first author a high-impact paper and develop expertise in one of the hottest areas of biology.
LSI welcomes new faculty member
The welcomes structural biologist Melanie Ohi, Ph.D., to its faculty.
Cryo-EM images reveal how key biological machine unfolds problem proteins
New cryo-EM research reveals 3-D snapshots of how a key biological machine unfolds a ribbon of protein through its central channel.
Scientists capture the first cryo-EM images of cellular target for Type 2 diabetes in action
Researchers have captured the first cryo-electron microscopy snapshots of a cellular target for Type 2 diabetes in action.
LSI welcomes new faculty member
The LSI is pleased to welcome structural biologist Michael Cianfrocco, Ph.D., to its faculty as an assistant research professor.
Ringing true: LSI scientists find solution to longstanding cell membrane puzzle
LSI researchers have developed a clear picture of a critical mechanism in the budding process that sends materials from the inside of the cell to far-flung places in the body.
Researchers ‘solve’ key Zika virus protein structure
Revealed: the molecular structure of a protein produced by the Zika virus that is thought to be involved in the virus’s reproduction and its interaction with a host’s immune system.
New atomic-level snapshots provide a map for the development of anti-parasite drugs
The first high-resolution snapshots of a deadly parasite's ribosome provide a detailed map of its structure to aid the design of new drugs.
Nature's chem lab: How microorganisms manufacture drugs
Researchers at the LSI have obtained for the first time three-dimensional snapshots of the “assembly line” within microorganisms that naturally produces antibiotics and other drugs.
Decoding dengue and West Nile
A team of scientists at U-M and Purdue University has discovered a key aspect both to how the viruses replicate in the cells of their host and how they manipulate the immune system as they spread.