About Us

The Center for Structural Biology is a comprehensive structural biology resource for researchers at the University of Michigan and beyond.

Part of the U-M Life Sciences Institute, the CSB includes:

  • a high-throughput protein laboratory for protein engineering
  • protein purification facilities for small- and large-scale protein production
  • macromolecular crystallization and crystallography laboratories for solving crystal structures of biological molecules
  • an X-ray facility with access to high energy synchrotron radiation

Our dedicated staff scientists have years of academic and industry experience, allowing us to provide expert guidance to researchers through every stage of a project — collaborating and consulting with researchers who use the facilities.

We also have a programmatic collaboration with the LSI's Center for Chemical Genomics, allowing the determination of target proteins in complex with compounds identified in high-throughput screening.

Our services are available to U-M researchers as well as to outside academic and industry partners.


July 13, 2020
The Center for Structural Biology has reopened on a limited basis. Our staff is available to assist with both internal and external projects.  Please reach out to lsi-structure@umich.edu with questions.
March 20, 2020
Based on direction from the University of Michigan leadership, the Center for Structural Biology will be closed for most services and walk-in use effective Friday, March 20 at 5:00 p.m. As a reminder, all UM Structure Seminars have been cancelled through April.
While our services that require in-lab work will be unavailable, we wanted to let you know that the following services will still be available:

·      consultations and project planning

·      bioinformatics work

·      support letters

·      crystallographic calculations

·      manuscript writing

·      services for COVID-19 research