Nature's chem lab: How microorganisms manufacture drugs
Researchers at the LSI have obtained for the first time three-dimensional snapshots of the “assembly line” within microorganisms that naturally produces antibiotics and other drugs.
Regulating cellular recycling
LSI researchers have discovered a key regulator of autophagy, the cellular recycling process involved in many human diseases. The finding illuminates potential new drug targets for cancer, neurodegeneration and other diseases.
New antibiotic active against MRSA and anthrax
Researchers at the LSI and the National Biodiversity Institute (INBio) in Costa Rica have discovered a new antibiotic that is active against both Methicillin-resistant Staphylococcus aureus (MRSA) and anthrax in laboratory tests.
Determining neural specificity
Researchers at U-M have shown that the specific connection of sensory neurons to the correct targets in the central nervous system in fruit flies is dependent on how active the neurons are.
How organelles get to the right place at the right time
LSI researchers have discovered a key enzyme responsible for regulating the final step in the movement of organelles during cell division and differentiation.
Decoding dengue and West Nile
A team of scientists at U-M and Purdue University has discovered a key aspect both to how the viruses replicate in the cells of their host and how they manipulate the immune system as they spread.
Targeting an aspect of Down syndrome
U-M researchers have determined how a gene that is known to be defective in Down syndrome is regulated and how its dysregulation may lead to neurological defects, providing insights into potential therapeutic approaches to an aspect of the syndrome.
Neuronal regeneration and the two-part design of nerve cells
LSI reseachers have evidence that a single gene controls both halves of nerve cells, and their research demonstrates the need to consider that design in the development of new treatments for regeneration of nerve cells.
Trapping PCSK9 to lower cholesterol
Targeting the transport mechanism for a destructive protein lowers blood cholesterol levels in mice.