Diverse perspectives drive discovery in the Cone lab
Roger Cone is not only the director of the LSI — he is also a distinguished researcher with an active research program that thrives on diverse viewpoints and areas of expertise.
From Liberia to LSI, and back again
A residency at the U-M Life Sciences Institute is helping one visiting scholar from Liberia build research capacity at his university.
LSI welcomes new faculty member
The LSI’s newest faculty member is studying how the brain controls rhythmic breathing — and how these same circuits might be recruited to help fight conditions such as sleep apnea and sudden infant death syndrome (SIDS).
Enzyme's structure reveals how nature performs rare molecular transformations
How one type of enzyme allows a microorganism to produce molecules with a wide range of potentially beneficial activities — from fighting insects to killing fungi.
Brain-gut communication in worms demonstrates how organs can work together to regulate lifespan
Cross-talk between tissues actively coordinates aging in a common model organism.
Clues to aging found in stem cells' genomes
In fruit flies, repeating genetic elements shrink with age but then expand in future generations, a resurgence that may help explain how some cells stay immortal.
Enzyme plays a key role in calories burned both during obesity and dieting
Former LSI Director Alan Saltiel and colleagues a identify a key player in the control of energy expenditure during both obesity and fasting.
New system can measure how fat cells start burning energy
A team of researchers has developed a new system to measure how fat cells can be activated to burn energy.
Scientists can now measure activity of key cancer cell-survival protein, an important step toward inhibiting it
Findings remove a barrier to developing potential therapies for cancer patients with poor prognoses.
Researchers identify new potential drug target for Huntington’s disease
New insights allowed researchers to ameliorate the effects of Huntington’s disease in a fruit fly model of the disease.
Diving into science diplomacy
Graduate student Amy Fraley recently joined faculty member David Sherman on his latest expedition in Cuba, where strict barriers have prevented access for nearly 60 years.
New grant program promotes trainee-initiated, collaborative research across LSI labs
A grant program that encourages trainees to take the lead and learn what others are doing in their labs
Video: What's cryo-EM and how is it revolutionizing biology?
U-M has one of the top cryo-EM labs in the country — learn more about how this technology is revolutionizing biology and how U-M is using it to study things like neurodegenerative diseases and bacterial infections.
U-M study reveals how cinnamon turns up the heat on fat cells
How a common holiday spice — cinnamon — might be enlisted in the fight against obesity
Seven U-M scientists, engineers named 2017 AAAS Fellows
LSI faculty member Shawn Xu was among the newly elected fellows of the American Association for the Advancement of Science.
Biocatalysts are a bridge to greener, more powerful chemistry
How enzyme catalysts can overcome the flaws of an important synthetic chemical process
Michigan Medicine enters drug discovery collaboration with AstraZeneca in Chronic Kidney Disease
Patients with Chronic Kidney Disease may benefit from a new collaboration between U-M and AstraZeneca, who have partnered to develop a new therapeutic strategy for treatment.
Tiny worms may offer new clues about why it’s so hard to quit smoking
A previously dismissed genetic mechanism may contribute to nicotine dependence.
Fat hormone linked to progression of fatty liver disease may hold key to new treatments
Scientists identify a key driver of the progression to the most harmful form of fatty liver disease.
Study by Russell Ryan and colleagues links mutations in Notch gene to role in B cell cancers
Reserach led by LSI affiliate faculty member Russell Ryan provides new insights into how Notch drives the growth of B-cell cancers
Form reveals function in new study of HIV-fighting protein
Findings provide clues about how one protein utilizes RNA binding to get into the HIV cell and mutate the virus' DNA.
LSI faculty member Daniel Klionsky receives Distinguished Faculty Achievement Award
LSI faculty member Daniel J. Klionsky was recognized for consistently demonstrating outstanding achievements in research, teaching and mentoring, service and a variety of other activities.
Chilled proteins and 3-D images: The cryo-electron microscopy technology that just won a Nobel Prize
LSI faculty members Michael Cianfrocco and Melanie Ohi explain the technology that won the 2017 Nobel Prize for Chemistry.
Pure Science, Pure Michigan
In the last century, Michigan was a driving engine of America’s manufacturing economy. Today, programs like the Perrigo Undergraduate Fellowship at the LSI are helping to fuel a new knowledge-based economy in the state.