Research collaboration reveals how a mutation in the MUTYH protein prevents it from doing its job repairing damaged DNA — and our DNA can function like an electrical wire, conveying important signals.
Scientists have determined how microscopic marine bacteria build a chemical compound that has important biological activity — using a chemical transformation rarely seen outside of the lab.
The same proteins that moderate nicotine dependence in the brain may be involved in regulating metabolism.
Researchers at the LSI are creating a legion of fruit flies to advance our understanding of Down syndrome, thanks to funding from the Klatskin-Sutker Discovery Fund.
Researchers have determined that so-called 'junk DNA' plays a crucial role in holding the genome together.
The LSI will lead a four-day cryo-electron microscopy workshop in June to introduce participants to common image processing software packages.
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A residency at the U-M Life Sciences Institute is helping one visiting scholar from Liberia build research capacity at his university.
Roger Cone is not only the director of the LSI — he is also a distinguished researcher with an active research program that thrives on diverse viewpoints and areas of expertise.
The LSI’s newest faculty member is studying how the brain controls rhythmic breathing — and how these same circuits might be recruited to help fight conditions such as sleep apnea and sudden infant death syndrome (SIDS).
How one type of enzyme allows a microorganism to produce molecules with a wide range of potentially beneficial activities — from fighting insects to killing fungi.
Cross-talk between tissues actively coordinates aging in a common model organism.
Former LSI Director Alan Saltiel and colleagues a identify a key player in the control of energy expenditure during both obesity and fasting.
A team of researchers has developed a new system to measure how fat cells can be activated to burn energy.
Findings remove a barrier to developing potential therapies for cancer patients with poor prognoses.
New insights allowed researchers to ameliorate the effects of Huntington’s disease in a fruit fly model of the disease.
A round-up of media stories about LSI research and researchers from 2017.
Graduate student Amy Fraley recently joined faculty member David Sherman on his latest expedition in Cuba, where strict barriers have prevented access for nearly 60 years.
A grant program that encourages trainees to take the lead and learn what others are doing in their labs
U-M has one of the top cryo-EM labs in the country — learn more about how this technology is revolutionizing biology and how U-M is using it to study things like neurodegenerative diseases and bacterial infections.
How a common holiday spice — cinnamon — might be enlisted in the fight against obesity
LSI faculty member Shawn Xu was among the newly elected fellows of the American Association for the Advancement of Science.
How enzyme catalysts can overcome the flaws of an important synthetic chemical process
Patients with Chronic Kidney Disease may benefit from a new collaboration between U-M and AstraZeneca, who have partnered to develop a new therapeutic strategy for treatment.