April 8, 2016

New investments are accelerating an innovative approach to discovering potential cancer treatments that was developed at the LSI.

John Tesmer and lab members
March 9, 2016

 Taking aim at a cancer's ability to spread.

A biofilm
February 16, 2016

 A new class of anti-biofilm compounds derived from marine microorganisms that show promise against a drug-resistant bacterium commonly associated with hospital-acquired infections.

brain illustration (wildpixel / Thinkstock)
January 26, 2016

A international team makes a key discovery about how the brain’s “garbage disposal” process works — and how little needs to go wrong in order for it to break down.

LSI building
December 31, 2015

A round-up of media stories about LSI research and researchers from 2015.

Dried pufferfish hanging in office
December 14, 2015

The newest member of the LSI faculty aims to bridge the gap between the powerful chemistry developed over millions of years of evolution by bacteria, fungi and other natural organisms, and cutting-edge synthetic chemistry techniques.

Junk food (cookelma / iStock / ThinkStock)
November 10, 2015

Identified: a pathway in the liver, controlled by a protein known as BAF60a, that contributes to the negative effects of a high-fat diet by stimulating the production of bile — which helps the body to absorb more cholesterol and other fats from the foods we eat.

Woman getting eye exam (Huntstock/Thinkstock)
November 5, 2015

A chemical that could potentially be used in eye drops to reverse cataracts, the leading cause of blindness, has been identified by a team of scientists from U-M and their collaborators.

Van Deenen Medal
October 30, 2015

LSI faculty member Daniel J. Klionsky was awarded the 2015 van Deenan Medal from the Institute of Biomembranes at Utrecht University in The Netherlands.

Banana in Hand (public domain via Wikimedia Commons)
October 23, 2015

A banana a day may not keep the doctor away, but a substance originally found in bananas and carefully edited by scientists could someday fight off a wide range of viruses, new research suggests.

Pedro Cuatrecasas
October 12, 2015

Pedro Cuatrecasas, M.D., a renowned leader in the pharmaceutical industry and co-chair of the University of Michigan Life Sciences Institute Scientific Advisory Board, is scheduled to receive honorary degrees at Winter Commencement 2015.

October 6, 2015

A team from the LSI, University of Illinois, Chicago, and University of Southern Denmark has identified a resistance mechanism against ketolides, a new type of antibiotics just entering widespread use.

yeast cells
September 1, 2015

Studies using yeast genetics have provided new, fundamental insights into the cell-division cycle, researchers at the LSI reported.

nanotubes
July 1, 2015

Certain types of stem cells use microscopic, threadlike nanotubes to communicate with neighboring cells LSI researchers have discovered.

Colorful nematodes (HeitiPaves/iStock/Thinkstock)
May 28, 2015

LSI research shows for the first time that the age-old temperature law does not apply equally to adults and developing young.

Mangrove Tunicate (photo by Michael Schofield)
May 27, 2015

For decades, scientists have known that ET-743, a compound extracted from the mangrove tunicate — a kind of sea squirt — can kill cancer cells. Until now, its precise origins were a mystery.

Neuronal overgrowth in Down syndrome model
May 19, 2015

A class of FDA-approved cancer drugs may be able to prevent problems with brain cell development associated with disorders including Down syndrome and Fragile X syndrome.

Graphcial abstract of bacterial diets
May 7, 2015

It’s going to be easier for scientists to use roundworms to study diet-sensitive genes thanks to an innovation led by the LSI.

Blood-forming stem cells
April 13, 2015

LSI-led research has identified a gene critical to controlling the body’s ability to create blood cells and immune cells from blood-forming stem cells — known as hematopoietic stem cells.

March 9, 2015

Organ transplantation has been one of the greatest successes of modern medicine. But one of its largest limitations comes from a patient’s immune system treating the new heart, or lung, or liver like a foreign invader.

Structure of lecithin-cholesterol acyltransferase
March 2, 2015

With the aid of X-ray crystallography, researchers at the University of Michigan have revealed the structures of two closely related enzymes that play essential roles in the body’s ability to metabolize excess lipids, including cholesterol.

February 12, 2015

Anna Mapp, Ph.D. has been awarded the 2015 Emil Thomas Kaiser Award from the Protein Society. The award recognizes a recent, highly significant contribution in applying chemistry to the study of proteins.

January 12, 2015

LSI researchers have identified how a promising drug in clinical trials for the treatment of obesity and related metabolic disorders improves the metabolism of sugar by generating a new signal between fat cells and the liver.

structure of PLCbeta3
December 9, 2014

How structural features of a critical enzyme found in the cardiovascular system influence its regulation of heart activity

colorful fat cells
November 17, 2014

LSI scientists have discovered how a previously unknown hormone serves as a messenger from fat cells to the liver and are investigating the potential of developing a new treatment for metabolic disorders.

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