August 21, 2018

Scientists revealed that a receptor protein in the brain acts as the body’s “energy rheostat,” ensuring that the balance of energy and fat does not drift too far above or below its homeostatic set point. The findings open new doors for developing anti-obesity drugs.

August 20, 2018

Researchers have determined how to target a class of proteins that have long been considered too “fuzzy” to target with small molecules, opening the door to new drug-discovery projects.

Lab beakers
August 2, 2018

With funding from the U-M College of Engineering's Blue Sky Initiative, a team of researchers is setting out to streamline the process for developing the next generation of antimicrobials.

July 30, 2018

Scientists uncover a potential new role for long noncoding RNA in obesity and non-alcoholic fatty liver disease.

July 18, 2018

Meet the new MLSF fellows, who are investigating important biological questions related to multiple sclerosis, triple-negative breast cancer, and how complex living architectures form.

July 10, 2018

When scientists discover a new phenomenon, they often get to name it. For researchers who study the model system Drosophila melanogaster, or fruit flies, that means participating in a long tradition that is a hallmark of the field’s culture.

July 9, 2018

Researchers shed new light on a fundamental cellular process — the formation of asters, star-shaped microtubule structures within cells that help cells to divide properly.

July 5, 2018

New research reveals the mechanism that one model organism uses to signal to neighboring cells when it’s time to move.

Cryo-EM workshop audience
June 28, 2018

Thirty-five academic and industry scientists from across the country got hands-on experience with the latest cryo-electron microscopy image processing tools at a recent workshop led by the LSI.

June 27, 2018

David Walt, Ph.D., sat down with LSI Director Roger Cone to discuss emerging trends in the life sciences, the importance of broadening access to scientific research opportunities and his advice for aspiring scientists

Symposium ad
June 27, 2018

the LSI’s annual Saltiel Life Sciences Symposium will bring pioneers in the field of single cell biology to the University of Michigan to discuss the scientific advances driving the field forward.

Wenjing Wang
June 20, 2018

The LSI's newest faculty member will use her protein engineering prowess to develop tools that can advance research across the fields of neuroscience and cell biology.

June 18, 2018

Research collaboration reveals how a mutation in the MUTYH protein prevents it from doing its job repairing damaged DNA — and our DNA can function like an electrical wire, conveying important signals.

May 23, 2018

Scientists have determined how microscopic marine bacteria build a chemical compound that has important biological activity — using a chemical transformation rarely seen outside of the lab.

May 21, 2018

The same proteins that moderate nicotine dependence in the brain may be involved in regulating metabolism.

April 23, 2018

Researchers at the LSI are creating a legion of fruit flies to advance our understanding of Down syndrome, thanks to funding from the Klatskin-Sutker Discovery Fund.

April 11, 2018

Researchers have determined that so-called 'junk DNA' plays a crucial role in holding the genome together.

Melanie Ohi and Amanda Erwin at the microscope
April 6, 2018

The LSI will lead a four-day cryo-electron microscopy workshop in June to introduce participants to common image processing software packages.

LSI building
April 4, 2018

Follow the LSI on LinkedIn to stay up-to-date with news and network with current and former members of the LSI community.

March 26, 2018

A residency at the U-M Life Sciences Institute is helping one visiting scholar from Liberia build research capacity at his university.


March 26, 2018

Roger Cone is not only the director of the LSI — he is also a distinguished researcher with an active research program that thrives on diverse viewpoints and areas of expertise.

Peng Li
March 20, 2018

The LSI’s newest faculty member is studying how the brain controls rhythmic breathing — and how these same circuits might be recruited to help fight conditions such as sleep apnea and sudden infant death syndrome (SIDS). 

Structure of the HpiC1 Stigonemataceae cyclase
March 12, 2018

How one type of enzyme allows a microorganism to produce molecules with a wide range of potentially beneficial activities — from fighting insects to killing fungi.

C. Elegans on a petri dish
February 28, 2018

Cross-talk between tissues actively coordinates aging  in a common model organism.


fruit fly
February 13, 2018
In fruit flies, repeating genetic elements shrink with age but then expand in future generations, a resurgence that may help explain how some cells stay immortal.