Scientists revealed that a receptor protein in the brain acts as the body’s “energy rheostat,” ensuring that the balance of energy and fat does not drift too far above or below its homeostatic set point. The findings open new doors for developing anti-obesity drugs.
Researchers have determined how to target a class of proteins that have long been considered too “fuzzy” to target with small molecules, opening the door to new drug-discovery projects.
With funding from the U-M College of Engineering's Blue Sky Initiative, a team of researchers is setting out to streamline the process for developing the next generation of antimicrobials.
Scientists uncover a potential new role for long noncoding RNA in obesity and non-alcoholic fatty liver disease.
Meet the new MLSF fellows, who are investigating important biological questions related to multiple sclerosis, triple-negative breast cancer, and how complex living architectures form.
When scientists discover a new phenomenon, they often get to name it. For researchers who study the model system Drosophila melanogaster, or fruit flies, that means participating in a long tradition that is a hallmark of the field’s culture.
Researchers shed new light on a fundamental cellular process — the formation of asters, star-shaped microtubule structures within cells that help cells to divide properly.
New research reveals the mechanism that one model organism uses to signal to neighboring cells when it’s time to move.
Thirty-five academic and industry scientists from across the country got hands-on experience with the latest cryo-electron microscopy image processing tools at a recent workshop led by the LSI.
David Walt, Ph.D., sat down with LSI Director Roger Cone to discuss emerging trends in the life sciences, the importance of broadening access to scientific research opportunities and his advice for aspiring scientists
the LSI’s annual Saltiel Life Sciences Symposium will bring pioneers in the field of single cell biology to the University of Michigan to discuss the scientific advances driving the field forward.
The LSI's newest faculty member will use her protein engineering prowess to develop tools that can advance research across the fields of neuroscience and cell biology.
Research collaboration reveals how a mutation in the MUTYH protein prevents it from doing its job repairing damaged DNA — and our DNA can function like an electrical wire, conveying important signals.
Scientists have determined how microscopic marine bacteria build a chemical compound that has important biological activity — using a chemical transformation rarely seen outside of the lab.
The same proteins that moderate nicotine dependence in the brain may be involved in regulating metabolism.
Researchers at the LSI are creating a legion of fruit flies to advance our understanding of Down syndrome, thanks to funding from the Klatskin-Sutker Discovery Fund.
Researchers have determined that so-called 'junk DNA' plays a crucial role in holding the genome together.
The LSI will lead a four-day cryo-electron microscopy workshop in June to introduce participants to common image processing software packages.
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A residency at the U-M Life Sciences Institute is helping one visiting scholar from Liberia build research capacity at his university.
Roger Cone is not only the director of the LSI — he is also a distinguished researcher with an active research program that thrives on diverse viewpoints and areas of expertise.
The LSI’s newest faculty member is studying how the brain controls rhythmic breathing — and how these same circuits might be recruited to help fight conditions such as sleep apnea and sudden infant death syndrome (SIDS).
How one type of enzyme allows a microorganism to produce molecules with a wide range of potentially beneficial activities — from fighting insects to killing fungi.
Cross-talk between tissues actively coordinates aging in a common model organism.