How does nature make it? Mapping cyanobacterial pathways in the search for new drugs
Researchers have mapped the complex chemistry involved in creating several types of bioactive compounds that are naturally produced inside bacteria.
Red light, green light: U-M research offers new insight about how a stem cell becomes a neuron
LSI scientists identified a molecular switch that triggers a stem cell’s progeny to commit to generating only differentiated cell types by giving up its “stemness.”
LSI Director Roger Cone named Asa Gray Collegiate Professor
LSI Director Roger Cone receives named professorship honoring the pioneering botanist Asa Gray.
A transcription factor runs through it
How fly fishing can help explain a new frontier of drug discovery
Tasting light: New type of photoreceptor is 50 times more efficient than the human eye
The new receptor protein has unusual characteristics that suggest potential future applications ranging from sunscreen to scientific research tools.
LSI scientist honored with Tsuneko and Reiji Okazaki Award
LSI faculty member Yukiko Yamashita, Ph.D., honored for her significant contributions to the field of biology
Good in small doses: Damaging chemicals may benefit brain, too
How chemicals that cause damaging oxidation to the nervous system may actually improve sensory function at low doses
U-M scientists develop a new strategy for inhibiting protein-protein interactions
Researchers blocked the dysregulated signaling associated with a 'master transcription factor,' which controls many different cellular decisions, without compromising its other biologically important functions.
Transcription factor can stifle breast cancer suppressing gene
A transcription factor known as Snail1 can act as a “molecular bypass” that diminishes the natural tumor suppressing action of a gene called p53 in breast cancer patients.
Two U-Michigan faculty elected to prestigious National Academy of Medicine
LSI Director Roger Cone is among the new members of the National Academy of Medicine of the National Academies, one of the highest honors in the fields of health and medicine.
Journey to Nepal: a story of science and family
David Sherman and his daughter traveled to Nepal in the search for microbes that produce beneficial molecules.
Targeting transcription: LSI researchers pursue new avenue for therapeutics
LSI researchers are breaking new ground in scientists’ quest to develop drugs that can target DNA transcription, which is dysregulated in a variety of diseases from cancer to diabetes.
Researchers ‘solve’ key Zika virus protein structure
Revealed: the molecular structure of a protein produced by the Zika virus that is thought to be involved in the virus’s reproduction and its interaction with a host’s immune system.
New atomic-level snapshots provide a map for the development of anti-parasite drugs
The first high-resolution snapshots of a deadly parasite's ribosome provide a detailed map of its structure to aid the design of new drugs.
An unexpected role for TMC proteins in alkaline sensing
An LSI study identified a new type of alkaline sensor in nematodes.
Roger Cone named director of the U-M Life Sciences Institute
Roger D. Cone, Ph.D., will serve as the new Mary Sue Coleman Director of the University of Michigan Life Sciences Institute, effective Sept. 1.
Q&A: Prof. David Sherman on research efforts to stay ahead of drug-resistant bacteria
Last week, health officials announced the first case in the U.S. of E. coli resistant to colistin, a “last resort” antibioti
Research investments bring potential cancer treatments one step closer
New investments are accelerating an innovative approach to discovering potential cancer treatments that was developed at the LSI.
New anti-biofilm compounds show promise against drug-resistant bacteria linked to hospital infections
A new class of anti-biofilm compounds derived from marine microorganisms that show promise against a drug-resistant bacterium commonly associated with hospital-acquired infections.
Breaking the brain’s garbage disposal: New study shows even a small problem causes big effects
A international team makes a key discovery about how the brain’s “garbage disposal” process works — and how little needs to go wrong in order for it to break down.
Beyond Nature's Chemistry
The newest member of the LSI faculty aims to bridge the gap between the powerful chemistry developed over millions of years of evolution by bacteria, fungi and other natural organisms, and cutting-edge synthetic chemistry techniques.
Researchers identify liver pathway linked to negative impacts of high-fat, high-cholesterol diet
Identified: a pathway in the liver, controlled by a protein known as BAF60a, that contributes to the negative effects of a high-fat diet by stimulating the production of bile — which helps the body to absorb more cholesterol and other fats from the foods we eat.