Study by Russell Ryan and colleagues links mutations in Notch gene to role in B cell cancers

Notch is one of the most frequently mutated genes in chronic lymphocytic leukemia (CLL), the most common leukemia in adults in the United States. It is also often mutated in other common B cell tumors, such as mantle cell lymphoma. However, the role of Notch in these cancers has been uncertain. Now, work done by Michigan Medicine’s Russell Ryan, MD, Assistant Professor of Pathology, and colleagues at Massachusetts General Hospital, Brigham and Women’s Hospital, and the University of Pennsylvania, provides new insights into how Notch drives the growth of B-cell cancers. The teams report their findings in Cell Reports.


Read the full story from the U-M Medical School Department of Pathology.

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Top Image: Chronic lymphocytic leukemia cells in the peripheral blood. Photo credit: Elizabeth Morgan, M.D.