Saltiel Life Sciences Symposium 2025: Speaker Bios and Poster Session

About the Speakers

Omar Abudayyeh is an assistant professor at Harvard Medical School, an investigator at Brigham and Women’s Hospital and Mass General Brigham’s Gene and Cell Therapy Institute, an associate member of the Broad Institute, and faculty member with the Department of Stem Cell and Regenerative Biology at Harvard University. He directs the Abudayyeh-Gootenberg lab, which is developing next-generation gene editing, gene delivery and synthetic biology technologies using protein engineering and artificial intelligence and applies them towards new therapeutics and the study of aging. He previously was a McGovern Fellow at MIT, where he directed his own research group. He earned his Ph.D. from Harvard Medical School and MIT, where he researched novel CRISPR enzymes for genome editing, therapeutics and diagnostics. He is a pioneer in the gene editing and AI bio fields as an inventor on dozens of patents and patent applications relating to gene editing, therapeutic, and diagnostic innovations. He is also co-founder of Sherlock Biosciences, Proof Diagnostics (acquired) and Tome Biosciences, which are commercializing CRISPR-based diagnostics and therapeutics, as well as other stealth starts ups in the gene and RNA therapy space, which have collectively raised hundreds of millions. He has been recognized as Technology Review Innovators Under 35, Bloomberg New Economy Catalyst, Endpoints 20 under 40 Next Generation of Biotech Leaders, 2022 Termeer Scholar, 2018 Forbes 30 under 30, Business Insider 30 under 30, a 2018 TEDMED Hive honoree, and a 2013 Paul and Daisy Soros Fellow. 

Cliff Brangwynne is the June K. Wu ‘92 Professor of Chemical and Biological Engineering at Princeton University, a Howard Hughes Medical Institute Investigator, and the founding director of the Omenn-Darling Bioengineering Institute. He obtained a B.S. in materials science from Carnegie Mellon University and Ph.D. in applied physics in from Harvard University. He was a visiting fellow at the Max Planck Institute for the Physics of Complex Systems in Dresden and was a Helen Hay Whitney Postdoctoral Fellow at the Max Planck Institute for Molecular Cell Biology and Genetics in Dresden. Since 2011 he has been a faculty member in the Department of Chemical and Biological Engineering at Princeton University. His primary research interests are in biological self-assembly, particularly in the role of intracellular liquid-liquid phase separation. He is the recipient of numerous awards, including a Searle Scholar Award, MacArthur Fellowship, Wiley Prize, HFSP Nakasone Award, and Breakthrough Prize.

Just Crocker is a group leader at the European Molecular Biology Laboratory (EMBL), where his lab aims to understand the fundamental principles driving development to allow for programming and predictive control of cell fates. He earned his Ph.D. in molecular and cellular biology from Dartmouth College and then completed his postdoctoral research at Princeton University and the Howard Hughes Medical Institute Janelia Research Campus.

Danwei Huangfu is a member and professor in the Developmental Biology Program at Sloan Kettering Institute of Memorial Sloan Kettering Cancer Center and the Joan & Sanford I. Weill Medical College of Cornell University. She received her B.S. in genetics from Fudan University in Shanghai, China, and her Ph.D. in neuroscience from Cornell University Weill Graduate School of Medical Sciences. She subsequently completed a postdoctoral fellowship with  Douglas Melton at Harvard University. In September 2010, she joined Sloan Kettering Institute of Memorial Sloan Kettering Cancer Center as an Assistant Member. The Huangfu lab is interested in human developmental genetics and stem cell biology. The lab applies precision genetics and genetic screening approaches in human pluripotent stem cells, including both embryonic and induced pluripotent stem cells, to understand both conserved and non-conserved aspects of human development and disease mechanisms. 

Pulin Li is a Whitehead Institute Member and an assistant professor of biology at Massachusetts Institute of Technology. She earned a bachelor’s degree in life sciences from Peking University and a Ph.D. in Chemical Biology at Harvard University in the lab of Leonard Zon. She then completed a postdoctoral fellowship with Michael B. Elowitz at the California Institute of Technology. Her lab studies how molecules and cells create tissue-scale patterns, as well as how these patterns regulate tissue form and function.

Michael Z. Lin is currently a professor of neurobiology and bioengineering at Stanford University. He received an A.B. summa cum laude in biochemistry (Harvard). After Ph.D. training in biochemistry and neurobiology with Michael Greenberg at Harvard Medical School, he received his M.D. from UCLA, then performed postdoctoral research in protein engineering with Chemistry Nobel Laureate Roger Y. Tsien at UCSD. He is a recipient of a Burroughs Wellcome Career Award for Medical Scientists, a Rita Allen Scholar Award, a Damon Runyon-Rachleff Innovation Award and an NIH Pioneer Award.

Changyang Linghu is an assistant professor in the Department of Cell and Developmental Biology, Department of Biomedical Engineering and Michigan Neuroscience Institute at the University of Michigan. He obtained his bachelor's degree in engineering ring from Tsinghua University and received his Ph.D. from the Massachusetts Institute of Technology working with Ed Boyden. He is the recipient of the NIH Director's New Innovator Award, MIT Technology Review's Global 35 Innovators Under 35 (TR35), Glenn and AFAR Junior Faculty Grant and Chan Zuckerberg Initiative Collaborative Pairs Pilot Project Award, among other recognitions. His research focuses on technology development for scalable and multiplexable interrogation of cell physiology.

Leonardo Morsut is an assistant professor of stem cell biology and regenerative medicine at the University of Southern California. He earned a Ph.D. from Padova University, where he identified roles of YAP/TAZ in mechanotransduction. He then completed his postdoctoral research at the University of California San Francisco, where he developed synthetic Notch receptors for applications in CAR-T cell therapies. In his lab at USC, trainees develop and use synthetic biology tools to control patterning, morphogenesis and functional differentiation of in vitro grown tissues.

James Nuñez is an assistant professor of molecular and cell biology at the University of California, Berkeley and an investigator of the Chan Zuckerberg Biohub – San Francisco. His lab innovates CRISPR technologies for perturbing the human epigenome and dissects fundamental pathways underlying epigenetic regulation using functional genomics, biochemistry and cell biology approaches. He completed postdoctoral training with Jonathan Weissman (UCSF) and Ph.D. training with Jennifer Doudna (UC Berkeley). He has been named a Hanna Gray Fellow of HHMI, a Pew Biomedical Scholar and an Alfred P. Sloan Foundation Research Fellow.

Jared Toettcher is an associate professor of molecular biology and the deputy director of the Omenn-Darling Bioengineering Institute at Princeton University. He obtained a Ph.D. from MIT working with Bruce Tidor (MIT) and Galit Lahav (Harvard Medical School) and was a postdoctoral fellow at UCSF with Wendell Lim and Orion Weiner. He has been named a 2016 NIH New Innovator, a 2019 Vallee Scholar and a 2024 Allen Distinguished Investigator and was awarded a 2018 NSF CAREER Award.

Li Ye is a professor, the Abide-Vividion Chair in Chemical Biology and an HHMI Investigator in the Department of Neuroscience at the Scripps Research Institute. He received his B.S. from Tsinghua University andd his Ph.D. from Harvard Medical School, followed by a postdoc at Stanford University. he joined Scripps Research in 2018 as an assistant professor and was promoted to full professor with tenure in 2023. He has received multiple awards, including Howard Hughes Medical Institute Investigator, NIH Director’s New Innovator Award and the Chan Zuckerberg Initiative’s Ben Barres Award, among others. The Ye lab combines neuroscience, molecular metabolism and chemical biology to understand the nervous systems and somatic tissues as an integrated network while focusing on the energetics as a fundamental mechanism underlying their relationship and interactions in normal physiology and disease conditions.

Poster Session

1. “High throughput mapping streptokinase-plasminogen interaction reveals residues critical for binding”
Authors: Srishti Baid, Laura M. Haynes , Matthew L. Holding, David Siemieniak, David Ginsburg
Presenter: Srishti Baid
Research Group: Ginsburg Lab
Research Areas: Blood coagulation and Fibrinolysis

2. “A DNA repair-reporter deep mutational scan comprehensively maps missense effects in MUTYH”
Authors: Shelby Hemkera, Ashley Marshb, Felicia Hernandezb, Grace Clarka, Alyssa Bashira, Krystal Jianga, Jacob O. Kitzmana
Presenter: Shelby Hemker
Research Group: Kitzman Lab
Research Areas: Cell biology

3. “De novo lipid droplets formation regulates Leukotriene B4 secretion from activated alveolar macrophages”
Authors: Subhash B. Arya, Shangyi Qian, Jennifer Speth, Marc Peters-Golden, Carole A. Parent
Presenter: Subhash Arya
Research Group: Parent Lab
Research Areas: Cell biology

4. “Deep mutational scanning analysis to define recognition motifs for the cargo receptors, LMAN1 and SURF4”
Authors: Jingcheng Wang, David Ginsburg
Presenter: Jingcheng Wang
Research Group: Ginsburg Lab
Research Areas: Cell biology

5. “The cell class/type diversification of the Drosophila lateral antennal lobe lineage”
Authors: Hui-Min Chen, Ching-Po Yang, Christabel Tan, Jui-Chun Kao, Tomer Stern, Tzumin Lee
Presenter: Hui-Min Chen
Research Group: T. Lee Lab
Research Areas: Developmental biology

6. “Decoding the functional map of PMS2, a clinically actionable tumor suppressor gene, by deep mutational scanning”
Authors: Sebastian Vishnopolska, Elena Glick, Jacob Kitzman
Presenter: Sebastian Vishnopolska
Research Group: Kitzman Lab
Research Areas: Mutational scanning

7. “Invitro generation of gonadal like somatic cells and testis organoids from mouse embryonic stem cells”
Authors: Umesh Kumar, Yu-Chi Shen, Jun Li, Saher Sue Hammoud
Presenter: Umesh Kumar
Research Group: Hammoud Lab
Research Areas: Stem cell engineering

8. “The cost of resilience: How loss of ZCWPW1 drives ovarian reserve depletion”
Authors: Dominic Bazzano, Wenxin Xie, Ameer Khilfeh, Francesca Cole, Sue Hammoud
Presenter: Dominic Bazzano, Ameer Khilfeh
Research Group: Hammoud Lab
Research Areas: Epigenome

9. “Assessing cellular contexts of type 2 diabetes-associated variants at scale”
Authors: Adelaide Tovar, Amy Etheridge, Romy Kursawe, Kirsten Nishino, Jonathan Rosen, Kui Sun, Swarooparani Vadlamudi, Ziwei Chen, Daniel DiCorpo, James Meigs, Alisa Manning, Anshul Kundaje, Kimberly Lorenz, Benjamin F. Voight, Sarah Schoenrock, Michael Stitzel, Ryan Tewhey, Karen Mohlke, Jacob Kitzman, Stephen C.J. Parker
Presenter: Adelaide Tovar
Research Groups:  Parker & Kitzman Labs
Research Areas: Gene regulation

10. “m6A modification links RNA binding protein-mediated mRNA decay to suppress tumorigenesis in developing fly brain”
Authors: Hideyuki Komori, Aifu Li, Kin Fai Au, Cheng-Yu Lee
Presenter: Hideyuki Komori
Research Groups: C.-Y. Lee Lab
Research Areas: Gene regulation

11. “Regulation of sex differences by the ancestral X-Y chromosomal gene pair Kdm5c-Kdm5d”
Authors: Rebecca Malcore, Milan Samanta, Shigeki Iwase, Sundeep Kalantry
Presenter: Rebecca Malcore
Research Group: Kalantry Lab
Research Areas: Gene regulation

12. “Reprogramming cell competency to bypass generation of transit amplifying progenitors halts tumorigenesis”
Authors: Cyrina Ostgaard, Arjun Rajan, Sophia Davidson, Cheng-Yu Lee
Presenter: Cyrina Ostgaard
Research Group: C.-Y. Lee Lab
Research Areas: Gene regulation

13. “Silencing of polycomb repressive complex 2 (PRC2) target genes in the absence of PRC2”
Authors: Itzaira Mercado-Hernandez, Clair Harris, Kritika Kasliwal, Sundeeo Kalantry
Presenter: Itzaira Mercado-Hernandez
Research Group: Kalantry Lab
Research Areas: Gene regulation

14. “Engineering circular guide RNA for CRISPR-Cas13d to target ADAR for triple-negative breast cancer”
Authors: Shurong Zhou, Suling Yang, Guizhi Zhu
Presenter: Shurong Zhou
Research Group: Guizhi Zhu
Research Areas: Genome editing

15. “Advancing (-)-premarineosin A as a potent antimalarial therapeutic via metabolic engineering and late-stage derivatization”
Authors: Christina M. McBride, Morgan McCauley, Natalia R. Harris, Sahar Amin, Brian J. Curtis, Linnea Verhey-Henke, Katherine L. Lev, Xin-zhuan Su Lab (NIAID), James Inglese Lab (NCATS), Filipa Pereira, David H. Sherman
Presenter: Christina M. McBride
Research Groups: Sherman & Pereira Lab
Research Areas: Metabolic engineering

16. “Engineering polymeric RNAs as innate immune agonists for combinatorial activation in cancer immunotherapy”
Authors: Yinying Yang, Elias Issa, Connie Wu
Presenter: Yinying Yang
Research Group: C. Wu Lab
Research Areas: RNA therapeutics

17. “A genetically encoded reporter array for monitoring neuromodulators in animal brains”
Authors: Jiahui Ding, Isabel Solowiej, Jian Weng, Peng Li, Wenjing Wang
Presenter: Jiahui Ding, Isabel Solowiej
Research Group: Wang Lab
Research Areas: Biosensors

18. “Mechanisms that underlie the assembly of a population-coding neural network that processes different intensities of sensory cues”
Authors: Ruonan Li, Yujia Hu, Elizabeth Cebul, Bing Ye
Presenter: Ruonan Li
Research Group: Ye Lab
Research Areas: Neuroscience

19. “A dedicated skin-to-brain circuit for cool sensation”
Authors: Hankyu Lee, Chia Chun Hor, Lorraine R Horwitz, Ailin Xiong, Xin-Yu Su, Daniel R Soden, Sarah Yang, Wei Cai, Wenwen Zhang, Chen Li, Christopher Radcliff, Abbey Dinh, Tin Long Rex Fung, Ilma Rovcanin, Kevin P Pipe, X.Z. Shawn Xu, Bo Duan
Presenter: Hankyu Lee
Research Group:  Duan lab
Research Areas: Neuroscience

20. “FOXP1 postmitotically specifies upper-layer neuron identity and thalamocortical circuitry”
Authors: Ikenna Njoku, Nancy Yao, Mandy Lam, Ethan O’Farrell, Kenneth Kwan
Presenter: Ikenna Njoku
Research Group: Kwan Lab
Research Areas: Neuroscience

21. “Molecular and circuit logic of cold sensing and cold pain”
Authors: Wenwen Zhang, Hankyu Lee, Chia Chun Hor, Adam State, Josh Sinha, Bo Duan, Shawn Xu
Presenter: Wenwen Zhang
Research Group: Xu Lab
Research Areas: Neuroscience

22. “Bitbow-empowered spectral connectomics and lineage tracing in Drosophila brains”
Authors: Ye Li, Jessica Tang, Nadia Sbisa, RoAnna Pollock, Kenneth Athukorala, Logan Walker, Dawen Cai
Presenter: Ye Li
Research Group: Cai Lab
Research Areas: Neuroscience

23. “Developing a novel chemogenetic tool for activation of endogenous melanocortin-4 receptor”
Authors: Ryan Singer, Jessi Rodriguez, Naima Dahir, Ashley Haralson, Luis Vázquez Rivera, Jiaqi Shen, Peng Li, Roger Cone, Wenjing Wang
Presenter: Ryan Singer
Research Groups: Wang Lab
Research Areas: Synthetic biology

24. “A pontomedullary circuit for state-dependent control of breathing”
Authors: Xingyu Li,Peng Li
Presenter: Xingyu Li
Research Group: Li Lab
Research Areas: Neuroscience