Recent News

An international research team is changing the understanding of the key cellular and molecular events that trigger graft-versus-host disease, an often-fatal complication of bone marrow transplants.

Researchers have mapped the  complex chemistry involved in creating several types of bioactive compounds that are naturally produced inside bacteria. 

 

LSI Director Roger Cone receives named professorship honoring the pioneering botanist Asa Gray. 

LSI scientists identified a molecular switch that triggers a stem cell’s progeny to commit to generating only differentiated cell types by giving up its “stemness.”

A round-up of media stories about LSI research and researchers from 2016.

How fly fishing can help explain a new frontier of drug discovery

The new receptor protein has unusual characteristics that suggest potential future applications ranging from sunscreen to scientific research tools.

LSI faculty member Yukiko Yamashita, Ph.D., honored for her significant contributions to the field of biology

How chemicals that cause damaging oxidation to the nervous system may actually improve sensory function at low doses

Researchers blocked the dysregulated signaling associated with a 'master transcription factor,' which controls many different cellular decisions, without compromising its other biologically important functions.

LSI Director Roger Cone is among the new members of the National Academy of Medicine of the National Academies, one of the highest honors in the fields of health and medicine. 

A transcription factor known as Snail1 can act as a “molecular bypass” that diminishes the natural tumor suppressing action of a gene called p53 in breast cancer patients.

David Sherman and his daughter traveled to Nepal in the search for microbes that produce beneficial molecules.

LSI researchers are breaking new ground in scientists’ quest to develop drugs that can target DNA transcription, which is dysregulated in a variety of diseases from cancer to diabetes.

Revealed: the molecular structure of a protein produced by the Zika virus that is thought to be involved in the virus’s reproduction and its interaction with a host’s immune system.

 The first high-resolution snapshots of a deadly parasite's ribosome provide a detailed map of its structure to aid the design of new drugs. 

Roger D. Cone, Ph.D., will serve as the new Mary Sue Coleman Director of the University of Michigan Life Sciences Institute, effective Sept. 1.

An LSI study identified a new type of alkaline sensor in nematodes.

Last week, health officials announced the first case in the U.S. of E. coli resistant to colistin, a “last resort” antibioti

New investments are accelerating an innovative approach to discovering potential cancer treatments that was developed at the LSI.

 Taking aim at a cancer's ability to spread.

 A new class of anti-biofilm compounds derived from marine microorganisms that show promise against a drug-resistant bacterium commonly associated with hospital-acquired infections.

A international team makes a key discovery about how the brain’s “garbage disposal” process works — and how little needs to go wrong in order for it to break down.

A round-up of media stories about LSI research and researchers from 2015.

The newest member of the LSI faculty aims to bridge the gap between the powerful chemistry developed over millions of years of evolution by bacteria, fungi and other natural organisms, and cutting-edge synthetic chemistry techniques.