Our laboratory investigates the mechanisms that regulate nutrient and energy metabolism in cells, tissues, and organisms. We focus on elucidating how nutritional signals engage transcription factors and cofactors to control metabolic gene programs, dissecting the regulatory code underlying circadian metabolic rhythms, and exploring how the metabolic properties of tissues are specified during development and altered in disease.
- Obesity-associated metabolic disease
- Signaling and gene transcription
- Metabolic tissue development
Jiandie Lin studies the signaling networks that control the storage and utilization of energy in cells and organisms, and how they contribute to obesity, diabetes, and cardiovascular disease.
Jiandie Lin's new research has challenged a long-held belief that whitening of skeletal muscle in diabetes is harmful. In fact, it helps keep blood sugar in check.
White muscle is good at providing short, intense bursts of energy. Because its increases in the bodies of people with diabetes, the red-to-white muscle shift was thought to make muscle less responsive to insulin. However, Lin's research indicates that obese mice with BAF60c transgene were much better at controlling blood glucose. If the BAF60c pathway is indeed the way in which cells form white muscle and in turn optimize metabolic function, it may be a promising drug target.
Meng Z, Li S, Ko HJ, Lee Y, Okutsu M, Yan Z, Kim JK, Lin JD (2013) BAF60c drives glycolytic muscle formation and improves glucose homeostasis through Deptor-mediated AKT activation. Nat. Med. 19:640-645.
Ma D, Molusky MM, Hu CR, Fang F, Rui C, Mathew AV, Pennathur S, Liu F, Cheng JX, Guan JL, Lin JD (2013) Autophagy deficiency by hepatic FIP200 deletion uncouples steatosis from liver injury in NAFLD. Mol. Endo. (in press)