Antibody blocks dengue virus's NS1 protein from interacting with host cells
January 7, 2021

A team of researchers has discovered an antibody that blocks the dengue virus’s ability to cause disease in mice. The findings open the potential for developing effective treatments and designing a vaccine for dengue and similar diseases.

SARS-CoV-2 spike protein binding to the human ACE2 receptor protein
May 7, 2020

U-M scientists are advancing a new antibody test to identify people who have been infected with the novel coronavirus that causes the COVID-19 disease.

Zinc-finger antiviral protein in complex with RNA
November 11, 2019

A new study reveals how an antiviral protein in our cells latches onto foreign invaders, and how some viruses — including HIV — evade capture.

Representation of fungi and the structure of a natural product they make
September 23, 2019

Researchers have solved a nearly 50-year-old mystery of how fungi produce a large class of bioactive compounds, revealing a chemical reaction reaction that is nearly unprecedented in nature

Structure of the FabZ enzyme
March 15, 2019

Research writes new chapter in the story of fatty acid biosynthesis and its potential for new antibiotics and renewable resources

Jonathan Nelson
February 15, 2019

LSI Outreach Awards recognize the value of our community members' efforts to connect research, teaching and service to the public

October 29, 2018

Three ground-breaking LSI projects are among the University of Michigan projects to be funded in the first round of investments from the Biosciences Initiative.

May 23, 2018

Scientists have determined how microscopic marine bacteria build a chemical compound that has important biological activity — using a chemical transformation rarely seen outside of the lab.

Structure of the HpiC1 Stigonemataceae cyclase
March 12, 2018

How one type of enzyme allows a microorganism to produce molecules with a wide range of potentially beneficial activities — from fighting insects to killing fungi.

LSI building
December 31, 2017

A round-up of media stories about LSI research and researchers from 2017.

Two molecules of restriction factor APOBEC3H form a sequence-independent complex with an RNA duplex.
October 18, 2017

Findings provide clues about how one protein utilizes RNA binding to get into the HIV cell and mutate the virus' DNA.

Mitchell Meyer
September 25, 2017

In the last century, Michigan was a driving engine of America’s manufacturing economy. Today, programs like the Perrigo Undergraduate Fellowship at the LSI are helping to fuel a new knowledge-based economy in the state.

LSI building
December 31, 2016

A round-up of media stories about LSI research and researchers from 2016.

Zika Virus NS1 structure
July 19, 2016

Revealed: the molecular structure of a protein produced by the Zika virus that is thought to be involved in the virus’s reproduction and its interaction with a host’s immune system.

Cryo-EM structure of the central enzyme in the assembly process that creates polyketides (Credit: Somnath Dutta)
June 18, 2014

Researchers at the LSI have obtained for the first time three-dimensional snapshots of the “assembly line” within microorganisms that naturally produces antibiotics and other drugs. 

NS1 protein
February 6, 2014

A team of scientists at U-M and Purdue University has discovered a key aspect both to how the viruses replicate in the cells of their host and how they manipulate the immune system as they spread.