Zhaohui Xu Lab

We use a multi-disciplinary approach to study molecular mechanisms involved in intracellular trafficking, which plays an important role in diseases such as cancer, viral infections and neurodegeneration.

Our Research

Our lab uses a multi-disciplinary approach of structural biology, biochemistry and cell biology to study molecular mechanisms of proteins that function in intracellular trafficking.

Our current focus is on the endosomal-sorting complex required for transport (ESCRT), a multi-component protein machinery essential for a wide range of biological processes including cell surface receptor down-regulation, enveloped virus budding, cytokinesis and autophagy.

Our work has therapeutic implications for diseases such as cancer, viral infection and neuro-degeneration.


Zhaohui Xu, Ph.D.

Research Associate Professor, U-M Life Sciences Institute
Associate Professor, Biological Chemistry, U-M Medical School
Director, Undergraduate Training, U-M Life Sciences Institute

Publication Highlights

Mechanism of Vps4 hexamer function revealed by cryo-EM

Su M, Guo EZ, Ding X, Li Y, Tarrasch JT, Brooks CL 3rd, Xu Z, Skiniotis G, Sci Adv. (2017)

Room 3163
Life Sciences Institute
Mary Sue Coleman Hall
210 Washtenaw Avenue
Ann Arbor, MI 48109-2216