The focus of our research is to address:
- how neuronal development contributes to the assembly and function of the nervous system
- how defects in this process lead to brain disorders
We have a broad interest in neuroscience, which includes how neurons develop dendrites and axons into distinct subcellular compartments, how neurons form specific connections to build neural networks, how information is processed through neural networks and how an animal’s experience interacts with the genome to shape neural networks. Moreover, we combine the strength of Drosophila and mouse systems to study the role of disregulated expression of genes (e.g., in Down syndrome) in brain disorders.
We take a multi-disciplinary approach to our investigations, incorporating genetics, cell biology, developmental biology, biochemistry, advanced imaging (for neuronal structures and activity), electrophysiology, computation (including machine learning and computer vision) and behavioral studies.