Bing Ye Lab

We investigate how neurons assemble into neural networks and how defects in this process lead to brain disorders.

Our Research

The focus of our research is to address:

  1. how neuronal development contributes to the assembly and function of the nervous system
  2. how defects in this process lead to brain disorders

We have a broad interest in neuroscience, which includes how neurons develop dendrites and axons into distinct subcellular compartments, how neurons form specific connections to build neural networks, how information is processed through neural networks and how an animal’s experience interacts with the genome to shape neural networks. Moreover, we combine the strength of Drosophila and mouse systems to study the role of disregulated expression of genes (e.g., in Down syndrome) in brain disorders. 

We take a multi-disciplinary approach to our investigations, incorporating genetics, cell biology, developmental biology, biochemistry, advanced imaging (for neuronal structures and activity), electrophysiology, computation (including machine learning and computer vision) and behavioral studies.

Bing Ye

Bing Ye, Ph.D.

Burton L. Baker Collegiate Professor of the Life Sciences
Research Associate Dean, U-M Life Sciences Institute
Research Professor, U-M Life Sciences Institute
Professor of Cell and Developmental Biology, U-M Medical School

Publication Highlights

Cross-modal modulation gates nociceptive inputs in Drosophila

Pan G, Li R, Xu G, Weng S, Yang XL, Yang L, Ye B, Curr Biol (2023)

DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse models

Liu H, Caballero-Florán RN, Hergenreder T, Yang T, Hull JM, Pan G, Li R, Veling MW, Isom LL, Kwan KY, Huang ZJ, Fuerst PG, Jenkins PM, Ye B, PLoS Biol (2023)

LabGym: Quantification of user-defined animal behaviors 1 using learning-based holistic assessment

Hu Y, Ferrario CR, Maitland AD, Ionides RB, Ghimire A, Watson B, Iwasaki K, White H, Xi Y, Zhou J, Ye B, Cell Reports Methods (2023)

A neural basis for categorizing sensory stimuli to enhance decision accuracy

Hu Y, Wang C, Yang L, Pan G, Liu H, Yu G, Ye B, Current Biology (2020)

isoTarget: A genetic method for analyzing the functional diversity of splicing isoforms in vivo

Liu H, Pizzano S, Li R, Zhao W, Veling MW, Hu Y, Yang L, Ye B, Cell Reports (2020)

Serotonergic Modulation Enables Pathway-Specific Plasticity in a Developing Sensory Circuit in Drosophila

Kaneko T, Macara AM, Li R, Hu Y, Iwasaki K, Dunnings Z, Firestone E, Horvatic S, Guntur A, Shafer OT, Yang CH, Zhou J, Ye B, Neuron (2017)

The Krüppel-Like Factor Dar1 Determines Multipolar Neuron Morphology

Wang X, Zhang MW, Kim JH, Macara AM, Sterne G, Yang T, Ye B, J Neurosci (2015)

GM130 is required for compartmental organization of dendritic Golgi outposts

Zhou W, Chang J, Wang X, Savelieff MG, Zhao Y, Ke S, Ye B, Curr Biol (2014)

Room 5403
Life Sciences Institute
Mary Sue Coleman Hall
210 Washtenaw Avenue
Ann Arbor, MI 48109-2216