Michigan was an early adopter of cryo-EM, and the a new grant from the U-M Biosciences Initiative positions the university to distinguish itself in the field further by hiring new faculty members and adopting new cryo-electron tomography (cryo-ET) and correlative light and electron microscopy (CLEM) technologies. This investment will increase the availability of cryo-EM to researchers across the university.
The Biosciences Initiative funding will also allow U-M to develop additional educational and training opportunities to bring the technique to labs across campus, as well as to provide more hands-on training to the growing ranks of practitioners across the world — building on the success of our first hands-on image processing workshop, which was held in 2018. The goal is to make U-M a leading institution and destination for growing the next generation of cryo-EM specialists.
With the new enhancements, our cryo-EM facility will include:
- two Titan Krios microscopes each with Volta phase plate, energy filter, and K3 direct electron detector
- Aquilos FIB-SEM
- Leica EM Cryo CLEM microscope
- Talos Arctica with K2 direct electron detector
- Glacios with Falcon 3EC direct electron detector and CetaD detector for microED
- Tecnai T12 with US4000 CCD detector
- Morgagni for negative stain screening
- picoliter-dispensing Chameleon sample preparation robot
- and two Vitrobot plunge-freezing devices
Education & Training
Support from the Biosciences Initiative is also helping us to invite leading experts in the field to campus as well as support hands-on workshops and training.
Recent speaker examples:
Justin Taraska, Ph.D., National Heart, Lung, and Blood Institute
Benjamin Engel, Ph.D., Max Planck Institute of Biochemistry
Elizabeth Villa, Ph.D., University of California, San Diego
Wolfgang Baumeister, Ph.D., Max Plank Institute of Biochemistry
To learn more about current and past workshop offerings, visit the Michigan Cryo-EM Workshops page.