Ongoing Enhancements

New funding through the U-M Biosciences Initiative will enable the university to become an international leader in the field and a premier destination for cryo-EM research and training.

 

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Michigan was an early adopter of cryo-EM, and the a new grant from the U-M Biosciences Initiative positions the university to distinguish itself in the field further by hiring new faculty members and adopting new cryo-electron tomography (cryo-ET) and correlative light and electron microscopy (CLEM) technologies. This investment will increase the availability of cryo-EM to researchers across the university.

The Biosciences Initiative funding will also allow U-M to develop additional educational and training opportunities to bring the technique to labs across campus, as well as to provide more hands-on training to the growing ranks of practitioners across the world — building on the success of our first hands-on image processing workshop, which was held in 2018. The goal is to make U-M a leading institution and destination for growing the next generation of cryo-EM specialists.

Equipment

With the new enhancements, our cryo-EM facility will include:

  • two Titan Krios microscopes each with Volta phase plate, energy filter, and K3 direct electron detector
  • Aquilos FIB-SEM
  • Leica EM Cryo CLEM microscope
  • Talos Arctica with K2 direct electron detector
  • Glacios with Falcon 3EC direct electron detector and CetaD detector for microED
  • Tecnai T12 with US4000 CCD detector
  • Morgagni for negative stain screening
  • picoliter-dispensing Chameleon sample preparation robot
  • and two Vitrobot plunge-freezing devices

New Hiring

We are currently seeking faculty candidates specializing in CLEM. Read the full job ad at the Biosciences Initiative website.

Education & Training

Support from the Biosciences Initiative is also helping us to invite leading experts in the field to campus as well as support hands-on workshops and training.

Recent speaker examples:

To learn more about current and past workshop offerings, visit the Michigan Cryo-EM Workshops page.