Weisman publications

Recent Articles

Jin, N., Jin, Y., Weisman, L.S. (2017). Early Protection to Environmental Stress Mediated by CDK-Dependent P13,5P2 Lipid Signaling from the vacuole/lysosome. J Cell Biol. 216:2075-2090. PMID:28637746 PubMed Link

Yau, R.G.W.*, Wong, S.*, and Weisman, L.S. (2017) Spatial Regulation of Organelle Release from Myosin V Transport by p21-Activated Kinases. J Cell Biol. 216:1557-1566. * Co-first authors. PMID: 28495836 PubMed Link

Hasegawa J, Strunk BS, Weisman L.S. (2017) PI5P and PI(3,5)P2: Minor, but Essential Phosphoinositides. Cell Struct Funct. PMID: 28302928 PubMed Link

Pappas SS, Bonifacino J, Danek A, Dauer WT, De M, De Franceschi L, DiPaolo G, Fuller R, Haucke V, Hermann A, Kornmann B, Landwehrmeyer B, Levin J, Neiman AM, Rudnicki DD, Sibon O, Velayos-Baeza A, Vonk JJ, Walker RH, Weisman L.S., Albin RL (2017) Eighth International Chorea-Acanthocytosis Symposium: Summary of Workshop Discussion and Action Points. Tremor Other Hyperkinet Mov (N Y). PMID: 28224046 PubMed Link

Lang, M, Strunk, BS, Azad N, Petersen JL, Weisman LS. (2017) An intramolecular interaction within the lipid kinase Fab1 regulates cellular phosphatidylinositol 3,5-bisphosphate lipid levels. Mol. Biol. Cell. 28:858-864. PMID:28148651 PubMed Link

Kim SM, Roy SG, Chen B, Nguyen TM, McMonigle RJ, McCracken AN, Zhang Y, Kofuji S, Hou J, Selwan E, Finicle BT, Nguyen TT, Ravi A, Ramirez MU, Wiher T, Guenther GG, Kono M, Sasaki AT, Weisman L.S., Potma EO, Tromberg BJ, Edwards RA, Hanessian S, Edinger AL (2016) Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways. J Clin Invest. PMID: 27669461 PubMed Link

Jin N., Lang, M., and Weisman, L.S. (2016) Phosphatidylinositol 3,5-bisphosphate: Regulation of cellular events in space and time. Biochemical Journal PMID: 26862203 PubMed Link

Hertz DL, Owzar K, Lessans S, Wing C, Jiang C, Kelly WK, Patel JN, Halabi S, Furukawa Y, Wheeler HE, Sibley A, Lassiter C, Weisman L.S., Watson D, Krens SD, Mulkey F, Renn CL, Small EJ, Febbo PG, Shterev I, Kroetz D, Friedman PN, Mahoney JF, Carducci MA, Kelley MJ, Nakamura Y, Kubo M, Dorsey SG, Dolan ME, Morris MJ, Ratain MJ, McLeod HL. (2016) Clin Cancer Res22:4890-4900. PMID: 2714368963 PubMed Link

Jin Y, Weisman L.S. (2015) The vacuole/lysosome is required for cell-cycle progression. Elife, Aug 31;4. PMID: 26322385 PubMed link

Jin, Y. Strunk, B.S., and Weisman, L.S. (2015) Close encounters with the lysosome third kind. Preview of Chu et al.  Cell, 161:197-198. PMCID: PMC4435959. PubMed link

McCartney, A., Zolov, S.N., Kauffman, E.J., Strunk, B.S., Zhang, Y., Weisman, L.S. and Sutton, M. (2014) Activity-dependent PI(3,5)P2 synthesis controls AMPA receptor trafficking during synaptic depression. PNAS 111:E4898-4905. PMCID: PMC4234577. PubMed link

Jin N., Mao K., Jin Y., Tevzade G., Kauffman E.J., Park S., Bridges D., Loewith R., Saltiel A.R., Klionsky D.J., Weisman L.S. (2014) Roles for PI3,5P2 in nutrient sensing through TORC1. Mol. Biol. Cell,  25:1171-1185. PMCID: PMC3967979. PubMed link

Yau, R.G.W., Peng, Y., Valiathan, R., Birkeland, S.R., Wilson, T.E. and Weisman, L.S. (2014) Release from myosin V via spatially regulated recruitment of an E3 Ub ligase controls organelle localization. Dev Cell,  28:520-533. PMCID: PMC3994899. PubMed link

Li, S.C., Diakov, T.T., Xu, T., Weisman, L.S., Couoh-Cardel, S., Wilkens, S., and Kane, P.M. (2014) The signaling lipid PI(3,5)P2 stabilizes V1-Vo sector interactions and activates the vacuolar H+-translocating ATPase. Mol Bio Cell, 25:1251-1262. PMCID: PMC3982991. PubMed link

Li, X., Wang, X., Zhang, X., Zhao, M., Tang, W.L., Zhang, Y., Yau, R.G.W.,Weisman, L.S. and Xu, H. (2013) Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics. PNAS, 110:21165-70. PMCID: PMC3876232. PubMed link

McCartney, A.J., Zhang, Y. and Weisman, L.S. (2013) Phosphatidylinositol 3,5-bis phosphate: Low abundance High significance. Bioessays, 36:52-64. PMCID: PMC3906640. PubMed PubMed Link  

Samie, M., Wang, X., Zhang, X., Goschka, A., Li, X., Cheng, X., Gregg, E., Azar, M., Zhuo, Y., Garrity, A.G., Gao, Q., Slaugenhaupt, S., Pickel, J., Zolov, S.N., Weisman, L.S., Lenk, G.M., Titus, S., Bryant-Genevier, M., Southall, N., Juan, M., Ferrer, M. and Xu, H. (2013) A TRP Channel in the Lysosome Regulates Large Particle Phagocytosis via Focal Exocytosis. Dev Cell. 26:511-24. PMCID: PMC3794471.  PubMed link

Zolov S.N., Bridges, D., Zhang Y., Lee, W-W., Riehle, E., Verma R., Lenk, G.M., Converso-Baran, K., Weide, T., Albin R.L., Saltiel, A.R., Meisler, M.H., Russell, M.W. and Weisman L.S. (2012) In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P. PNAS, 109:17472-7. PMCID: PMC3491506. PubMed link

Zhang, Y., McCartney, A.J., Zolov, S.N., Ferguson, C., Meisler, M., Sutton, M.A. and Weisman, L.S. (2012) Modulation of Synaptic Function by VAC14, a Protein that Regulates the Phosphoinositide PI(3,5)P2. EMBO J. 31:3442-56. PMCID: PMC3419932. PubMed link

Bridges, D., Ma, J.T., Parks, S., Inoki, K., Weisman, L.S. and Saltiel, A.R. (2012) Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1. Mol Bio Cell, 15:2955-62. PMCID: PMC3408421. PubMed link

Eves P.T., Jin Y., Brunner M.J., and Weisman L.S. (2012) Overlap of cargo binding sites on myosin V coordinates the inheritance of diverse cargoes. J. Cell Biol. 198:69-85. PMCID: PMC3392941. PubMed link

Bridges, D., Fisher, K., Zolov, S.N., Xiong, T., Inoki, K., Weisman, L.S., and Saltiel, A.R. (2012) Rab5 Proteins Regulate the Activation and Localization of Target of Rapamycin Complex 1. J. Biol Chem. 287:20913-21. PMCID: PMC3375515. PubMed link

Vaccari, I., Dina, G., Tronchère, H., Kaufman, E. Chicanne, G., Cerr, F., Wrabetz, L., Payrastre, B., Quattrini, A., Weisman, L.S., Meisler, M. and Bolino, A. (2011) Human Genetic Interaction between MTMR2 and FIG4 Phospholipid phosphatases Involved in Charcot-Marie-Tooth Neuropathies. PLoS Genet. 10:e1002319. PMCID: PMC3197679. PubMed link

Sultana, A., Dregger, C., Jin, Y., Franklin, E, Weisman, L.S. and Khan, A.R. (2011) The Activation Cycle of Ypt32 Reveals Structural Determinants of Effector Recruitment by Yeast Rab GTPases. FEBS Lett. 585:3520-7. PMCID: PMC3222890. PubMed link

Jin, Y., Sultana, A., Gandhi, P., Franklin, E. Hamamoto, S., Khan A.R., Munson, M., Schekman, R. and Weisman L.S. (2011) Myosin V transports secretory vesicles via a Rab GTPase cascade and interaction with the exocyst complex. Developmental Cell 21:1156-70. PMCID: PMC3241923. PubMed link

Lenk, G.M., Ferguson, C.J., Chow, C.Y., Jin, N, Jones, J.M., Grant, A.E., Zolov, S.N., Winters, J.J., Giger, R.J., Dowling, J.J., Weisman, L.S. and Meisler, M.H. (2011) Pathogenic Mechanism of the FIG4 Mutation Responsible for Charcot-Marie-Tooth Disease CMT4J. PLoS Genet. 7:e1002104: PMCID: PMC3107197. PubMed link

Birkeland, S.R., Jin, N., Ozdemir, A.C., Lyons, R.H. Jr., Weisman, L.S. and Wilson, T.E. (2010) Discovery of mutations in Saccharomyces cerevisiae by pooled linkage analysis and whole-genome sequencing. Genetics 186:1127-37 PMCID: PMC2998298. PubMed link

Dong, X., Shen, D., Wang, X. Dawson, T., Li X., Zhang, Q. Cheng, X., Zhang, Y., Weisman, L.S., Delling, M. and Xu, H. (2010) PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome. Nat. Commun., 1:38. PMCID: PMC2928581. PubMed link

Fagarasanu, A., Mast, F.D., Knoblach., B., Jin, Y., Brunner, M.J., Logan, M.R., Glover, M., Eitzen, G.A., Aitchison, J.D., Weisman, L.S., and Rachubinski, R.A. (2009) Myosin-driven peroxisome partitioning in S. cerevisiae. J. Cell Biol., 186:541-54. PMCID: PMC2733749. PubMed link

Jin, Y., Eves, P.T., Tang, F. and Weisman, L.S. (2009) PTC1 is required for vacuole inheritance and promotes the association of the myosin-V vacuole-specific receptor complex. Mol. Biol. Cell, 20:1312-1323. PMCID: PMC2649272. PubMed link

Chow, C.Y., Landers, J.E., Bergren, S.K., Sapp, P.C., Grant, A.E., Jones, J.M., Everett, L., Lenk, G.M., McKenna-Yasek, D.M., Weisman, L.S., Figlewicz, D., Brown, R.H., and Meisler, M.H. (2009) Deleterious variants of FIG4, a phosphoinositide phosphatase, in patients with ALS. Am J Hum Genet., 84:85-8. PMCID: PMC2668033. PubMed link

Jin N., Chow, C.Y., Liu, L., Zolov, S.N., Bronson, R., Ward-Bailey, P.F., Davisson, M., Petersen, J.L., Zhang, Y., Park, S., Duex, J., Goldowitz, D., Meisler, M.H., and Weisman, L.S. (2008) VAC14 nucleates a protein complex that is essential for the acute interconversion of PI3P and PI(3,5)P2 in yeast and mouse. EMBO J., 27:3221-34. PMCID: PMC2600653. PubMed link

Lipatova, Z., Tokarev A., Jin, Y., Mulholland, J., Weisman, L.S. and Segev, N. (2008) Direct interaction between a myosin V motor and the Rab GTPases Ypt31/32 is required for polarized secretion. Mol. Biol. Cell, 19:4177-87. PMCID: PMC2555963. PubMed link

Peng, Y. and Weisman L.S. (2008) The cyclin-dependent kinase, Cdk1, directly regulates vacuole inheritance. Developmental Cell, 15:478-485. PMCID: PMC2727752. PubMed link

Lodhi, I., Bridges, D., Chiang, S., Zhang, Y., Cheng, A., Geletka, L.M., Weisman, L.S. and Saltiel, A.R. (2008) Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5. Mol Biol Cell, 19:2718-2728. PMCID: PMC2441665. PubMed link

Valiathan, R. and Weisman, L.S. (2008) Pushing for answers: is myosin V directly involved in moving mitochondria? J. Cell Biol., 181:5-18. PMCID: PMC2287276. PubMed link

Zhang, Y, Zolov, S.N., Chow, C.Y., Slutsky, S.G., Richardson, S.C., Piper, R.C., Yang, B., Nau, J.J., Westrick, R.J., Morrison, S.J., Meisler, M.H. and Weisman, L.S. (2007) Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice. Proc Natl Acad Sci USA, 104:17518-17523. PMCID: PMC2077288. PubMed link

Chow, C.Y., Zhang, Y., Dowling, J., Jin, N., Adamska, M., Shiga, K., Szigeta, L., Shy, M., Li, J., Zhang, X., Lupski, J.R., Weisman, L.S. and Meisler, M.H. (2007) Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J. Nature 448:68-72. PMCID: PMC2271033. PubMed link

Peng, Y., Tang, F. and Weisman L.S. (2006) Palmitoylation plays a role in targeting Vac8p to specific membrane microdomains. Traffic 7:1378-87. PMID: 16978392. PubMed link

Tang, F. Peng, Y., Nau, J.J. and Weisman L.S. (2006) Vac8p, an armadillo repeat protein, coordinates vacuole inheritance with multiple vacuolar processes. Traffic, 7:1368-77. PMID: 16824055. PubMed link

Deux, J.E., Nau, J.J. Kauffman, E.J. and Weisman, L.S. (2006) Phosphoinositide 5-phosphatase Fig 4p is required for both acute rise and subsequent fall in stress-induced phosphatidylinositol 3,5-bisphosphate levels. Eukaryotic Cell 5:723-731. PMCID: PMC1459661. PubMed link

Deux, J.E., Tang, F. and Weisman, L.S. (2006) The Vac14p/Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover. J. Cell Biol., 172:693-704. PMCID: PMC2063702. PubMed link

Pashkova, N., Jin, Y., Ramaswamy, S. and Weisman, L.S. (2006) Structural basis for myosin V discrimination between distinct cargoes. EMBO J., 25:693-700. PMCID: PMC1383548. PubMed link

Pashkova, N., Catlett, N.L., Novak, J.L. and Weisman, L.S. (2005) A point mutation in the cargo-binding domain of myosin V affects its interaction with multiple cargoes. Eukaryotic Cell, 4:787-798. PMCID: PMC1705953. PubMed link

Pashkova, N., Catlett, N.L., Novak, J.L., Wu, G., Lu, R., Cohen, R.E. and Weisman, L.S. (2005) Myosin V attachment to cargo requires the tight association of two functional sub-domains. J. Cell Biol., 168:359-364. PMCID: PMC2171732. PubMed link

Articles (1995-2004)

Wang, C.W., Stromhaug, P.E., Kauffman, E.J., Weisman, L.S. and Klionsky, D.J. (2003) Yeast homotypic vacuole fusion requires the Ccz1-Mon1 complex during the tethering/docking stage. J. Cell Biol., 163:973-85. PMCID: PMC1705953. PubMed link

Ishikawa, K., Catlett, N.L., Novak, J.L., Tang, F., Nau, J.J. and Weisman, L.S. (2003) Identification of an organelle-specific myosin-V receptor. J. Cell Biol., 160:887-897. PMCID: PMC2173761. PubMed link

Tang, F., Kauffman, E. J., Novak, J.L., Nau, J.J., Catlett, N.L. and Weisman, L.S. (2003) Regulated degradation of a class V myosin receptor directs movement of the yeast vacuole. Nature, 422:87-92. PMID: 12594460. PubMed link

Gary, J.D., Sato, T.K., Stefan, C.J., Bonangelino, C.J., Weisman, L.S. and Emr, S.D. (2002) Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member. Mol. Biol. Cell, 13:1238-1251. PMCID: PMC102265. PubMed link

Bonangelino, C.J., Nau, J.J., Duex, J.E., Brinkman, M.R. Wurmser, A.E., Gary, J.D., Emr, S.D. and Weisman, L.S. (2002) Osmotic stress induced increase of phosphatidylinositol 3,5 bisphosphate requires Vac14p an activator of the lipid kinase, Fab1p. J. Cell Biol., 156:1015-1028. PMCID: PMC2173454. PubMed link

Wang, Y.X., Kauffman, E.J., Duex, J.E. and Weisman, L.S. (2001) Fusion of docked membranes requires the armadillo repeat protein Vac8p. J. Biol. Chem., 276:35133-35140. PMID: 11441010. PubMed link

Scott, S.V., Nice, D.C. III, Nau, J.J., Weisman, L.S., Kamada, Y., Keizer-Gunnink, I., Funakoshi, T., Veenhuis, M., Ohsumi,Y. and Klionsky, D.J. (2000) Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting. J. Biol. Chem., 275:25840-25849. PMID: 10837477. PubMed link

Catlett, N.L., Duex, J.E., Tang, F. and Weisman, L.S. (2000) Two distinct regions in a yeast myosin V tail domain are required for the movement of different cargoes. J. Cell Biol., 150:513-525. PMCID: PMC2175197. PubMed link

Catlett, N.L. and Weisman, L.S. (1998) The terminal tail-region of a yeast myosin-v mediates its attachment to vacuole membranes and sites of polarized growth. Proc. Natl. Acad. Sci. USA, 95:14799-14804. PMCID: PMC24529. PubMed link

Gary, J.D, Wurmser, A.E., Bonangelino, C..J., Weisman, L.S. and Emr, S.D. (1998) FAB1 encodes a PtdIns(3)P 5-kinase essential for the maintenance of vacuole size and membrane homeostasis. J. Cell Biol., 143:65-79. PMCID: PMC2132800. PubMed link

Bryant, N.J., Piper, R.C., Weisman, L.S. and Stevens, T.H. (1998) Retrograde traffic out of the yeast vacuole to the TGN occurs via the prevacuolar/endosomal compartment. J. Cell Biol., 142:651-663. PMCID: PMC2148167. PubMed link

Bonangelino, C., Catlett, N.L. and Weisman, L.S. (1997) Vac7p, a novel vacuolar protein is required for normal vacuole inheritance and morphology. Molec. Cell Biol., 17:6847-6858. PMCID: PMC232541. PubMed link

Hill, K.L., Catlett, N.L. and Weisman, L.S. (1996) Actin and myosin function in directed vacuole movement during cell division in Saccharomyces cerevisiae. J. Cell Biol., 135:1535-1550. PMCID: PMC2133941. PubMed link

Wang, Y.X., Catlett, N.L. and Weisman, L.S. (1998) Vac8p, a vacuolar protein with armadillo repeats, functions in both vacuole inheritance and protein targeting from the cytoplasm to the vacuole. J. Cell Biol., 140:1063-1074. PMCID: PMC275988. PubMed link

Wang, Y.X., Zhao, H., Harding, T., Gomes de Mesquita, D., Woldringh, C.L., Klionsky, D., Munn, A. and Weisman, L.S. (1996) Multiple classes of yeast mutants are defective in vacuole partitioning yet target vacuole proteins correctly. Molec. Biol. Cell, 7:1375-1389. PMCID: PMC275988. PubMed link

Nicolson, T.A., Weisman, L.S., Payne, G.S. and Wickner, W. (1995) A truncated form of the PHO80 cyclin redirects the PHO85 kinase to disrupt vacuole inheritance in S. cerevisiae. J. Cell Biol., 130:835-845. PMCID: PMC2199970. PubMed link

Articles (1984-1994)

Weisman, L.S. and Wickner, W. (1992) Molecular characterization of VAC1, a gene required for vacuole inheritance and vacuole protein sorting. J. Biol. Chem., 267:618-623. PMID: 1730622. PubMed link

Weisman, L.S., Emr, S.D. and Wickner, W. (1990) Mutants of Saccharomyces cerevisiae that block intervacuole vesicular traffic and vacuole division and segregation. Proc. Natl. Acad. of Sci. USA, 87:1076-1080. PMCID: PMC53413. PubMed link

Bryant N.J., Piper, R.C., Weisman, L.S. and Stevens, T.H. (1998) Retrograde traffic out of the yeast vacuole to the TGN occurs via the prevacuolar/endosomal compartment. J Cell Biol., 142:651-63. PMCID: PMC2148167. JBC Link

Weisman, L.S. and Wickner, W. (1988) Intervacuole exchange in the yeast zygote: a new pathway in organelle communication. Science, 241:589-591. PMID: 3041591. PubMed link

Weisman, L.S. and Ballou, C.E. (1988) Methanol formation in Mycobacterium smegmatis. J. Bacteriol., 170:1393-1395. PMCID: PMC210923. PubMed link

Weisman, L.S., Bacallao, R. and Wickner, W. (1987) Multiple methods of visualizing the yeast vacuole permit an evaluation of its morphology and inheritance during the cell cycle. J. Cell Biol., 105:1539-1547. PMCID: PMC2114659. PubMed link

Weisman, L.S., Krummel, B.M. and Wilson, A.C. (1986) Evolutionary shift in the site of cleavage of Prelysozyme. J. Biol. Chem., 261:2309-2313. PMID: 3511061. PubMed link

Weisman, L.S. and Ballou, C.E. (1984) Biosynthesis of the mycobacterial methylmannose polysaccharide - identification of a 3-0-methyltransferase. J. Biol. Chem., 259:3464-3469. JBC Link

Weisman, L.S. and Ballou, C.E. (1984) Biosynthesis of the mycobacterial methylmannose polysaccharide - identification of an a1?4 mannosyltransferase. J. Biol. Chem., 259:3457-3463. PubMed link