Sherman publications

Hansen, D. A., Koch, A. A., Sherman, D. H. 2017. Identification of a thioesterase bottleneck in the pikromycin pathway through full-module processing of unnatural pentaketides. J. Am. Chem. Soc. Aug 24. PubMed link

Koch, A. A., Hansen, D. A., Shende, V. V., Furan, L. R., Houk, K. N., Jiménez-Osés, G., Sherman, D. H. 2017. A single active site mutation in the pikromycin thioesterase generates a more effective macrocyclization catalyst. J. Am. Chem. Soc. Aug 24. PubMed link

Hagan, A. K., Tripathi, A., Berger, D., Sherman, D. H., Hanna, P. C. 2017. Petrobactin is exported from Bacillus anthracis by the RND-type exporter ApeX. mBio 8:e01238-17. PubMed link

Almutairi, M. M., Svetlov, M. S., Hansen, D. A., Khabilibullina, N. F., Klepacki, D., Kang, H.- Y., Sherman, D. H., Vasquesz-Laslop, N., Polikanov, Y. S., Mankin, A. S. 2017. Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins. Nucl. Acids Res. (in press). 

Fraley, A. E., Garcia-Borràs, M., Tripathi, A., Khare, D., Mercado-Marin, E. V., Tran, H., Dan, Q., Webb, G., Watts, K., Crews, P., Sarpong, R., Williams, R. M., Smith, J. L., Houk, K. N., Sherman, D. H. 2017. Function and structure of MalA/MalA', iterative halogenases for late-stage C-H functionalization of indole alkaloids. J. Am. Chem. Soc. 139(34):12060-12068. PubMed link

Tay, J.-H., Arguelles, A. J., DeMars, M. D., Zimmerman, P. M., Sherman, D. H., Nagorny, P. 2017. Regiodivergent glycosylations of 6-deoxy-erythronolide B and oleandomycin-derived macrolides enabled by chiral acid catalysis. J. Am. Chem. Soc. 139(25):8570-8578.  PubMed link

Paul, S., Ludeña, Y., Villena, G. K., Yu, F., Sherman, D. H. and Gutiérrez-Correa, M. 2017 High- quality draft genome sequence of a biofilm forming lignocellulolytic Aspergillus niger strain ATCC 10864. Standards in Genomic Sciences (2017) 12:37. PubMed link

Lowell, A.N., DeMars, M.D., Slocum, S.T., Yu, F., Anand, K., Chemler, J.A., Korakavi, N., Priessnitz, J.K., Park, S.R., Koch, A.A., Schultz, P.J., Sherman, D.H. 2017. Chemoenzymatic total synthesis and structural diversification of tylactone-based macrolide antibiotics through late-stage polyketide assembly, tailoring, and C-H functionalization. J. Am. Chem. Soc. 139: 7913−7920. PubMed link

Tietz, D. R., Podust, L. M., Sherman, D. H., Pochapsky, T. C. 2017. Solution conformations and dynamics of substrate-bound cytochrome P450 MycG. Biochemistry 56(21):2701-2714. PubMed link

Paul, S., Zhang, A., Ludeña, Y., Villena, G. K., Yu, F., Sherman, D. H., Gutiérrez-Correa, M. 2017. Insights from the genome of a high alkaline cellulase producing Aspergillus fumigatus strain obtained from Peruvian Amazon rainforest. J. Biotechnol. Apr 12. pii: S0168-1656(17)30164-5.  PubMed link

Koryakina, I., Kasey, C., McArthur, J. B., Lowell, A. N., Chemler, J. A., Li, S., Hansen, D. A., Sherman, D. H., Williams, G. J. 2017. Inversion of extender unit selectivity in the erythromycin polyketide synthase by acyltransferase domain engineering. ACS Chem. Biol. 12(1):114-123. acschembio.6b00732

Li, Z., Du, L., Zhang, W., Zhang, X., Jiang, Y., Liu, K., Men, P., Xu, H., Fortman, J. L, Sherman, D. H., Yu, B., Gao, S., Li, S. 2017. Complete Elucidation of the Late Steps of Bafilomycin Biosynthesis in Streptomyces lohii. J. Biol. Chem. 2017 Mar 14. pii: jbc.M116.751255. PMID:28292933

Li, S., Lowell, A. N., Newmister, S. A., Yu, F., Williams, R. M., Sherman, D. H. 2017. Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids. Nature Chem. Biol. (on-line publication, March 13, 2017). 10.1038/nchembio.2327 http://dx.doi.org/

Zhang, X., Li, Z., Du, L., Chlipala, G. E., Lopez, P. C., Zhang, W., Sherman, D. H., Li, S. 2016. Identification of an unexpected shunt pathway provides new insights into tirandamycin biosynthesis. Tet. Lett. 59:5919-5923.

Maloney, F. P., Gerwick, L., Gerwick, W. H., Sherman, D. H., Smith, J. L. 2016. Anatomy of the β-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate. Proc. Natl. Acad. Sci. USA. 113(37):10316-21. DOI: 10.1073/pnas.1607210113. PubMed link 

Tripathi, A., Choi, S. S., Sherman, D. H., Kim, E. S. 2016. Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412. J. Ind. Microbiol. Biotechnol. 43:1189–1193. PubMed link

Klas, K., Tsukamoto, S., Sherman, D. H., Williams, R. M. 2015 Natural Diels-Alderases: Elusive and irresistable. J. Org. Chem. 80(23):11672-11685. DOI: 10.1021/acs.joc.5b01951. PubMed link

Skiba, M., Sikkema, A., Fiers, W., Gerwick, W. H., Sherman, D. H., Aldrich, C. C., Smith, J. L. 2016. Domain organization and active site architecture of a polyketide synthase C-methyltransferase. ACS Chem. Biol. 11(12): PubMed link

Chatterjee, P., Davis, D., Yu, F., James, S., Wildschutte, J., Wiegmann, D., Sherman, D. H., McKay, R., LiPuma, J., and Wildschutte, H. 2016. Environmental pseudomonads inhibit cystic fibrosis patient-derived Pseudomonas aeruginosa. Appl. Env. Microbiol. Nov 23. pii: AEM.02701-16. [Epub ahead of print]. PubMed link

Fiers, W. D., Dodge, G. J., Sherman, D. H., Smith, J. L., Aldrich, C. C. 2016. Vinylogous dehydration by a polyketide dehydratase domain in curacin biosynthesis. J. Am. Chem. Soc. 2016. 138(49). PubMed link

Kleigrewe, K., Almaliti, J., Tian, I. Y., Kinnel, R. B., Korobeynikov, A., Monroe, E. A., Duggan, B. M., Di Marzo, V., Sherman, D. H., Dorrestein, P. C., Gerwick, L., Gerwick, W. H. 2015. Combining mass spectrometric metabolic profiling with genomic analysis: A powerful approach for discovering natural products from cyanobacteria. J. Nat. Prod. 78(7) PubMed Link

Newmister, S. A., Gober, C., Romminger, S., Yu, F., Tripathi, A., Parra, L. L., Williams, R. M., Berlinck, R., Joullié, M., Sherman D. H. 2016. OxaD, a versatile indolic nitrone synthase from the marine derived fungus Penicillium oxalicum F30. J. Amer. Chem. Soc. DOI: 10.1021/jacs.6b04915. PubMed Link

DeMars, M. D., Sheng, F., Park, S. R., Lowell, A. N., Podust, L. M., and Sherman, D. H. 2016. Biochemical and structural characterization of MycCI, a versatile P450 biocatalyst from the mycinamicin biosynthetic pathway. ACS Chem. Biol. PubMed link

Kleigrewe, K., Gerwick, L., Sherman, D. H., Gerwick, W. H. 2016 Unique marine derived cyanobacterial biosynthetic genes for chemical diversity. Nat Prod Rep. Jan 13. [Epub ahead of print] Review. PMID 26758451. PubMed link

Park, S. R., Tripathi, A., Wu, J., Pamela J. Schultz, P. J., Isaiah Yim, I., McQuade, T. J., Yu, F., Arevang, C. J., Mensah, A. Y., Tamayo-Castillo, G., Xi, C., Sherman, D. H. 2016. Discovery of cahuitamycins A-E, potent biofilm inhibitors derived from a convergent biosynthetic pathway. Nature Communications. 16;7:10710. doi: 10.1038/ncomms10710. PubMed link

Bertin, M. J, Vulpanovici, A., Monroe, E. A., Korobeynikov, A., Sherman, D. H., Gerwick, L., Gerwick, W. H. 2016. The phormidolide biosynthetic gene cluster: a trans-AT PKS pathway encoding a toxic macrocyclic polyketide. Chembiochem. 17(2):164-173. PubMed link

Kagiyama, I., Kato, H., Nehira, T., Frisvad, J. C., Sherman, D. H., Williams, R. M., and Tsukamoto, S. 2015. Taichunamides: Prenylated indole alkaloids from Aspergillus taichungensis (IBT 19404). Angew. Chem. Intl. Ed. 55, 1128–1132. PubMed link

Li, S., Lowell, A. N., Yu, F., Raveh, A., Newmister, S. A., Bair, N., Schaub, J. M., Williams, R. M. and Sherman, D. H. 2015. Hapalindole/ambiguine biogenesis is mediated by a Cope re-arrangement, C-C bond-forming cascade. J. Amer. Chem. Soc. Dec 2 [Epub ahead of print] 10.1021/jacs.5b10136. PubMed link

Khare, D., Hale, W. A., Tripathi, A., Gu, L., Sherman, D. H., Gerwick, W. H., Håkansson, K., Smith, J. L. 2015. Structural basis for cyclopropanation by a unique enoyl-acyl carrier protein reductase. Structure. 2015 Dec. 1;23(12):2213-23. PubMed link

Almutairi, M. M., Park, S. R., Rose, S., Hansen, D. A., Laslop-Vazques, N., Douthwaite, S., Sherman, D. H., Mankin, A. S. 2015. Resistance to ketolide antibiotics through coordinated expression of rRNA methyltransferases in bacterial producer of natural ketolides. Proc. Natl. Acad. Sci. USA. 112(42):12956-12961. PubMed link

Medema, M. H. et al., Minimum Information about a Biosynthetic Gene cluster. 2015. Nat. Chem. Biol. 11(9):625-631. PubMed link

Boudreau, P. D., Monroe, E. A., Mehrotra, S., Desfor, S., Korobeynikov, A., Sherman, D. H., Murray, T. F., Gerwick, L., Dorrestein, P. C., Gerwick, W. H. 2015. Expanding the described metabolome of the marine cyanobacterium Moorea producens JHB through orthogonal natural products workflows. PLoS One. 2015 Jul 29;10(7): PubMed link

Cheng, K. C., Cao, S., Raveh, A., MacArthur, R., Dranchak, P., Chlipala, G., Okoneski, M. T., Guha, R., Eastman, R. T., Yuan, J., Schultz, P. J., Su, X. Z., Tamayo-Castillo, G., Matainaho, T., Clardy, J., Sherman, D. H., Inglese, J. 2015. Actinoramide A identified as a potent antimalarial from titration-based screening of marine natural product extracts. J. Nat. Prod. 78(10):2411-2422. PubMed link

Sidhu, A., Miller, J., Tripathi, A., Garshott, D., Brownell, A., Chiego, D., Arevang, C.-J., Zeng, Q., Jackson, L., Bechler, S., Callaghan, M., Yoo, G., Sethi, S., Lin, H.-S., Callaghan, J., Tamayo-Castillo, G., Sherman, D. H., Kaufman, R., Fribley, A. 2015. Borrelidin induces the unfolded protein response in oral cancer cells and Chop-dependent apoptosis. ACS Med. Chem. Lett. 6(11): 1122–1127. DOI: 10.1021/acsmedchemlett.5b00133

Cruz, P.G., Fribley, A.M., Miller, J.R., Larsen, M.J., Schultz, P.J., Jacob, R.T., Tamayo-Castillo, G., Kaufman, R.J., Sherman, D.H. 2015. Novel lobophorins inhibit oral cancer cell growth and induce Atf4-and chop-dependent cell death in murine fibroblasts. ACS Med. Chem. Lett. 6(8):877-891. PubMed link

Chemler, J.A., Tripathi, A., Hansen, D.A., O'Neil-Johnson, M., Williams, R.B., Starks, C., Park, S.R., Sherman, D.H. Evolution of efficient modular polyketide synthases by homologous recombination. J. Am. Chem. Soc. 2015 Aug 26;137(33):10603-9. PubMed link

Narayan, A.R., Jimenez-Oses, G., Liu, P., Negretti, S., Zhao, W., Gilbert, M.M., Ramabhadran, R.O., Yang, Y.F., Furan, L.R., Li, Z., Podust, L.M., Montgomery, J., Houk, K.N., Sherman, D.H. 2015. Enzymatic hydroxylation of an unactivated methylene C-H bond guided by molecular dynamics simulations. Nat. Chem. 7(8): 653-660. PubMed link

Sherman, D.H., Tsukamoto, S., Williams, R.M. 2015. Comment on "Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence".  Science. 349(6244):149. PubMed link

Kleigrewe, K., Almaliti, J., Tian, I.Y., Kinnel, R.B., Korobeynikov, A., Monroe, E.A., Duggan, B.M., Di Marzo, V., Sherman, D.H., Dorrestein, P.C., Gerwick, L., Gerwick, W.H. 2015. Combining mass spectrometric metabolic profiling with genome analysis: a powerful approach for discovering natural products from cyanobacteria. J. Nat. Prod. 78(7):  1671-1682. PubMed link

Lowell, A.N., Santoro, N., Swaney, S.M., McQuade, T.J., Schultz, P.J., Larsen, M.J., Sherman, D.H. 2015. Microscale adaptation of in vitro transcription/ translation for high throughput screening of natural product extract libraries. Chem. Biol. Drug Des. {Epub ahead of print}. PubMed link

Schofield, M.M., Jain, S., Porat, D., Dick, G.J., Sherman, D.H. 2015. Identification and analysis of the bacterial endosymbiont specialized for production of the chemotherapeutic natural product ET-743. Environ. Microbiol. 2015. Oct;17(10):3964-75. PubMed link

Hansen, D.A., Koch, A.A., Sherman. D.H. 2015. Substrate controlled divergence in polyketide synthase catalysis. J. Am. Chem. Soc. 137(11):3735-3738. PubMed link

Smith, J.L., Skiniotis, G., Sherman, D.H. 2015. Architecture of the polyketide synthase module: surprises from electron cryo-microscopy. Curr. Opin. Struct. Biol. 31:9-19. PubMed link

Bernard, S.M., Akey, D.L., Triapthi, A., Park S.-R., Konwerski, J.R., Anzai, Y., Li, S., Kato, F., Sherman, D.H., Smith, J.L. 2015. Structural basis of substrate specificity and regiochemistry in the MycF/TylF family of sugar O-methyltransferases. ACS Chem. Biol. 10(5): 1340-1351. PubMed link

Kato, H., Nakahara, T., Sugimoto, K. Matsuo, K., Kagiyama, I., Frisvad, J.C., Sherman, D.H., Williams, R.M., Tsukamoto, S. 2015. Isolation of notoamide S and enantiomeric 6-epi-stephacidin A from the fungs Aspergillus amoenues: biogenetic implications. Org. Lett. 17(3): 700-703. PubMed link

Kato, H., Nakahara, T., Yamaguchi, M. Matsuo, K., Kagiyama, I., Finefield, J.M., Sunderhaus, J.D., Sherman, D.H., Williams, R.M., Tsukamoto, S. 2015. Bioconversion of 6-epi-Notoamide T produces metabolites of unprecedented structures in a marine-derived Aspergillus sp. Tetrahedron Lett. 56(1): 247-251. PubMed link

Delekta, P.C., Raveh, A., Larsen, M.J., Schultz, P.J., Tamayo-Castillo, G., Sherman, D.H., Miller, D.J. 2014. The combined use of alphavirus replicons and Pseudoinfectious particles for the discovery of antivirals derived from natural products. J. Biomol. Screen.20(5): 673-680. PubMed link

Raveh, A., Schultz, P.J., Aschermann, L.,  Carpenter, C., Tamayo-Castillo, G., Cao, S., Clardy, J., Neubig, R.R., Sherman, D.H., Sjorgen, B. 2014. Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts. Mol. Pharmacol. 86(4): 406-416. PubMed link

Dutta, S., Whicher, J.R., Hansen, D.A., Hale, W.A., Chemler, J.A., Congdon, G.R., Narayan, A.R., Hakansson, K., Sherman, D.H., Smith, J.L., Skiniotis, G. 2014. Structure of a modular polyketide synthase. Nature. 510(7506): 512-517. PubMed link

Whicher, J.A., Dutta, S., Hansen, D.A., Hale, W.A., Chemler, J.A., Dosey, A.M., Narayan, A.R., Hakansson, K., Sherman, D.H., Smith, J.L., Skiniotis, G. 2014. Structural rearrangements of a polyketide synthase module during its catalytic cycle. Nature. 510(7506):560-564. Pubmed link

Newmister, S.A., Sherman, D.H. 2014. Crystal structures of acyl carrier protein in complex with two catalytic partners show a dynamic role in cellular metabolism. ChemBioChem. 15(8):1079-1081. PubMed link

Walter, G.M., Raveh, A., McQuade, T. J., Arevang, C.J., Schultz, P. J., Smith, M. C., Asare, S., Cruz, P. G., Wisen, S., Matainaho, T., Sherman, D.H ., Gestwicki, J. E. 2014. High throughput screen of natural product extracts in a yeast model of polyglutamine proteotoxicity.  Chem. Biol. Drug Des. 83(4):440-449. PubMed link

Negretti, S., Narayan, A.R., Chiou K.C., Kells, P.M., Stachowski, J., Hansen, D., Podust, L., Montgomery, J., Sherman, D.H. 2014. Directing group-controlled regioselcetivity in an enzymatic C-H bond oxygenation.  J. Am. Chem. Soc. 136(13):4901-4904. PubMed link

Zhang, W., Liu, Y., Yan, J., Cao, S., Bai, F., Yang, Y., Huang, S., Yao, L., Anzai, Y., Kato, F., Podust, L.M., Sherman, D.H. , Li, S. 2014. New reactions and products resulting from alternative interactions between the P450 enzyme and redox partners.   J. Am. Chem. Soc. 136(9):3640-3646.  PubMed link

Coates, R.C., Podell, S., Korobeynikov, A., Lapidus, A., Pevzner, P., Sherman, D.H., Allen, E.E., Gerwick, L., Gerwick, W.H. 2014. Characterization of cyanobacterial hydrocarbon composition and distribution of biosynthetic pathways.  PLoS One   9(1):e85140  PubMed link

Larsen, M.J., Larsen, S.D., Fribley, A., Grembecka, J., Homan, K., Mapp, A., Haak, A., Nikolovska-Coleska, Z., Stuckey, J.A., Sun, D., Sherman, D.H.  2014. The role of HTS in drug discovery at the University of Michigan.  Comb. Chem. High Throughput Screen. 2014. Mar;17(3):210-30. PubMed link

Tripathi A., Schofield, M.M., Chlipala, G.E., Schultz, P.J., Yim, I., Newmister, S.A., Nusca, T.D., Scaglione, J.B., Hanna, P.C., Tamayo-Castillo, G., Sherman, D.H. 2013. Baulamycins A and B, broad-spectrum antibiotics identified as inhibitors of siderophore biosynthesis in Staphylococcus aureus and Bacillus anthracis.  J. Amer. Chem. Soc. 2014. 136(4):1579-86.  PubMed link

Raveh A., Delekta P. C., Dobry, C. J., Schultz, P. J., Blakely, P. K., Tai, A. W., Matainaho, T., Irani, D. N., Sherman, D.H. , Miller, D. H. 2013. Discovery of potent broad spectrum antivirals derived from marine actinobacteria.  PLoS One.   8(12):e82318  PubMed link

Whicher, J.R., Smaga, S.S., Hansen, D.A., Brown, W.C., Gerwick, W.H., Sherman, D.H., et al. 2013. Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis.  Chem. Biol.   20(11):1340-1351.  PubMed link

Hansen, D.A., Rath, C.M., Eisman, E.B., Narayan, A.R., Kittendorf, J.D., Mortison, J.D., Yoon, Y.J., Sherman, D.H. 2013. Biocatalytic synthesis of pikromycin, methymycin, neomethymycin, novamethymycin, and ketomethymycin.  J. Am. Chem. Soc.   135(30): 11232-11238.  PubMed link

Schofield, M.M., Sherman, D.H. 2013. Meta-omic characterization of prokaryotic gene clusters for natural product biosynthesis.  Curr. Opin. Biotechnol. 2013. Dec;24(6):1151-8. pii:S0958-1669(13)00115-8.  PubMed link

Zhang, W., Fortman, J.L., Carlson, J.C., Yan, J., Liu, Y., Bai, F., Guan, W., Jia, J., Matainaho, T., Sherman, D.H. , Li, S. 2013. Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii.  Chembiochem.  14(3):301-306.  PubMed link

Narayan, A.R., Sherman, D.H. 2013. Chemistry. Re-engineering nature's catalysts.  Science.  339(6117):283-284.  PubMed link

Sunderhaus, J.D., McAfoos, T.J., Finefield, J.M., Kato, H., Li, S., Tsukamoto, S., Sherman, D.H. , Williams, R.M. 2013. Synthesis and bioconversions of notoamide T: a biosynthetic precursor to stephacidin a and notoamide B.   Org Lett.  . 15(1): 22-25.  PubMed link

Kim, E.J., Lee, J.H., Choi, H., Pereira, A.R., Ban, Y.H., Yoo, Y.J., Kim, E., Park, J.W., Sherman, D.H. , Gerwick, W.H., Yoon, Y.J. 2012. Heterologous production of 4-O-demethylbarbamide, a marine cyanobacterial natural product.   Org Lett.   14(23):5824-5827.  PubMed link

Majmudar, C.Y., Hojfeldt, J.W., Arevang, C.J., Pomerantz, W.C., Gagnon, J.K., Schultz, P.J., Cesa, L.C., Doss, C.H., Row, S.P., Vasquez, V., Tamayo-Castillo, G., Cierpicki, T., Brooks, C.L. 3rd., Sherman D.H ., Mapp, A.K. 2012. Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300.  Angew Chem Intl Engl.  51(45):11258-62.  PubMed link

Li, S., Tietz, D.R., Rutaganira, F.U., Kells, P.M., Anzai, Y. , Kato, F., Pochapsky, T.C., Sherman D.H ., Podust, L.M. 2012. Substrate recognition by the multifunctional cytochrome P450 MycG in mycinamicin hydroxylation and epoxidation reactions. J Biol Chem.  287(45):37880-90.  PubMed link

Kim, D., Nah, J.H., Choi, S.S., Shin, H.S., Sherman D.H. , Kim, E.S. 2012. Biological activities of an engineered tautomycetin analogue via disruption of tmcR-encoding hydroxylase in Streptomyces sp. CK4412  J Ind Microbiol Biotechnol. 39(10):1563-8.  PubMed link

Podust, L.M., Sherman D.H ., 2012.Diversity of P450 enzymes in the biosynthesis of natural products.  Nat Prod Rep. 29(10): 1251-1266.  PubMed link

McCarthy, J.G., Eisman, E.B., Kulkarni, G., Gerwick, L., Gerwick, W.H., Wipf, P., Sherman D.H ., Smith, J.L. 2012. Structural basis of a functional group activation by sulfotransferases in complex metabolic pathways.   ACS Chem Biol.   7(12):1994-2003.  PubMed link

Jacob, R.T., Larsen, M.J., Larsen, S.D., Kirchoff, P.D., Sherman, D.H., Neubig, R.R. 2012. MScreen: an integrated compound management and high-throughput screening data storage and analysis system. J Biomol Screen. 17(8): 1080-1087.  PubMed link

Anzai, Y., Tsukada, S., Sakai, A., Masuda, R., Harada, C., Domeki, A., Li, S., Kinoshita, K., Sherman D.H. , Kato, F. 2012. Function of cytochrome P450 enzymes MycCl and MycG in Micromonospora griseorubida, a producer of the macrolide antibiotic mycinamicn.  Antimicrob Agents Chemother.   56(7): 3648-3656. PubMed link

Lee, M.J., Kong, D., Han, K., Sherman, D.H ., Bai, L., Deng, Z., Lin, S., Kim, E.S. 2012. Structural analysis and biosynthetic engineering of a solubility-improved and less-hemolytic nystatin-like polyene in Pseudonocardia autotrophica.   Appl Microbiol Biotechnol.  95(1): 157-168.  PubMed link

Bolduc, K., Larsen, S.D.,Sherman D.H . . 2012. Efficient, divergent synthesis of cryptophycin unit A analogues. Chem Commun (Camb)  May 22. {Epub ahead of print} PubMed link

Finefield, J.M.,Sherman D.H., Kreitman, M., Williams, R.M. 2012. Enantiomeric natural products: occurrence and biogenesis.  Angew Chem Int Ed Engl.  51(20):4802-4836. PubMed link

Nusca, T.D., Kim, Y., Maltseva, N., Eschenfeldt, W.H., Stols, L., Schofield, M.M., Scaglione, J.B., Dixon, S.D., Oves-Costales, D., Challis, G.L., Hanna, P.C., Pfleger, B.F., Joachimiak, A., Sherman D.H . 2012. Functional and structural analysis of the siderophore synthetase AsbB through reconstitution of the petrobactin biosynthetic pathway from Bacillus anthracis.   J Biol Chem.   287(19): 16058-16072.  PubMed link

Chemler, J.A., Buchholz, T.J., Geders, T.W., Akey, D.L., Rath, C.M., Chlipala, G.E., Smith, J.L., Sherman D.H. 2012. Biochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs Acyl-ACP as a starter unit donor.   J AM Chem Soc.  134(17): 7359-7366.  PubMed link

Finefield, J.M., Frisvad, J.C., Sherman D.H. , Williams, R.M. 2012. Fungal origins of the bicyclo[2.2.2]diazaoctane ring system of prenylated indole alkaloids.  J Nat Prod.   75(4): 812-833.  PubMed link

Busche, A.E., Gottstein, D., Hein, C., Ripin, N., Pader, I., Tufar, P., Eisman, E.B., Gu, L., Walsh, C.T., Loehr, F., Sherman, D.H. , Güntert, P., Dötsch, V. 2011. Characterization of molecular interactions between ACP and halogenase domains in the curacin A polyketide synthase.   ACS Chem Biol  17;7(2):378-386.  PubMed link

Gehret, J.J., Gu, L., Geders, T.W., Brown, W.C., Gerwick, L., Gerwick, W.H., Sherman, D.H. , Smith, J.L. 2011. Structure and activity of DmmA, a marine haloalkane dehalogenase.   Protein Sci.  21(2):239-248.  PubMed link

Li, S., Finefield, J.M., Sunderhaus, J.D., McAfoos, T.J., Williams, R.M., Sherman D.H. . 2012. Biochemical characterization of NotB as an FAD-dependent oxidase in the biosynthesis of notoamide indole alkaloids.  J Am. Chem. Soc.   134(2): 788-791.

Shareef, R.,Sherman, D.H. , Montgomery, J. 2011. Nickel-catalyzed regiodivergent approach to macrolide motifs.   Chem. Sci.   3(3) 892-895. PubMed link

Cruz, P.G., Auld, D.S., Schultz, P.J., Lovell, S., Battaile, K.P., Macarthur, R., Shen, M., Tamayo-Castillo, G., Inglese, J., Sherman, D.H. 2011. Titration-based screening forevaluation of natural product extracts: identification of an aspulvinone family of luciferase inhibitors.  Chem. Biol.  18(11): 1442-1452.  PubMed link

Rath, C.M., Janto, B., Earl, J., Ahmed, A., Hu, F.Z., Hiller, L., Dahlgren, M., Kreft, R., Yu, F., Wolff, J.J., Kweon, H.K., Christiansen, M.A., Hakansson, K., Williams, R.M., Ehrlich, G.D., Sherman, D.H.  2011. Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743.  ACS Chem. Biol.  6(11):1244-1256. PubMed link

Akey, D.L., Li, S., Konwerski, J.R., Confer, L.A., Bernard, S.M., Anzai, Y., Kato, F., Sherman, D.H. , Smith, J.L. 2011. A new structural form in the SAM/metal-dependent O-methyltransferase family: MycE from the mycinamicin biosynthetic pathway.   J. Mol. Biol.  413(2): 438-450.  PubMed link

Bonnett, S.A., Rath, C.M., Shareef, A.R., Joels, J.R., Chemler, J.A., Hakansson, K., Reynolds, K., Sherman, D.H.  2011. Acyl-CoA subunit selectivity in the pikromycin polyketide synthase PikAIV: steady-state kinetics and active-site occupancy analysis by FTICR-MS.  Chem. Biol.  18(9): 1075-1081.  PubMed link

Ding, Y., Rath, C.M., Bolduc, K.L., Hakansson, K., Sherman, D.H. 2011.Chemoenzymatic synthesis of cryptophycin anticancer agents by an ester bond forming NRPS module.  J. Am. Chem. Soc.  133(37): 14492-14495.  PubMed link

Fribley, A.M., Cruz, P.G., Miller, J.R., Callaghan, M.U., Cai, P., Narula, N., Neubig, R.R., Showalter, H.D., Larsen, S.D., Kirchoff, P.D., Larsen, M.J., Burr, D.A., Schultz, P.J., Jacobs, R.R., Tamayo-Castillo, G., Ron, D., Sherman, D.H. , Kaufman, R.J. 2011. Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response.  J. Biol. Screen.  16(8):825-835.  PubMed link

Finefield, J.M., Sherman, D.H. , Tsukamoto, S., Williams, R.M. 2011. Studies on the biosynthesis of the notoamides: synthesis of an isotopomer of 6-hydroxydeoxybrevianamide e and biosynthetic incorporation into notoamide j.  J. Org. Chem.  76(15): 5954-5958.  PubMed link

Finefield, J.M., Kato, H., Greshock, T.J., Sherman, D.H. , Tsukamoto, S., Williams, R.M. 2011. Biosynthetic studies of the notoamides: isotopic synthesis of stephacidin a and incorporation into notoamide B and sclerotiamide.  Org. Lett.  13(15): 3802-3805.  PubMed link

Carlson, J.C., Li, S., Gunatilleke, S.S., Anzai, Y., Burr, D.A., Podust, L.M., Sherman, D.H. 2011.Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect.  Nat. Chem.  3(8): 628-633.  PubMed link

Singh, S., Chang, A., Goff, R.D., Bingman, C.A., Gruschow, S., Sherman, D.H. , Phillips, G.N. Jr., Thorson, J.S. 2011. Structural characterization of the mitomycin 7-O-methyltransferase.  Proteins  79(7): 2181-2185.  PubMed link

Gehret, J.J., Gu, L., Gerwick, W.H., Wipf, P.,Sherman, D.H. , Smith, J.L. 2011.Terminal alkene formation by the thioesterase of curacin A biosynthesis: structure of a decarboxylating thioesterase.  J. Biol. Chem.  286(16): 14445-144454.  PubMed link

Finefield, J.M., Greshock, T.J., Sherman, D.H. , Tsukamoto, S., Williams, R.M. 2011. Notoamide E: Biosynthetic incorporation into notoamides C and D in cultures of Aspergillus versicolor NRRL 35600.   Tetrahedron Lett.  52(16):1987-1989.  PubMed link

Sunderhaus, J.D., Sherman, D.H. , William, R.M. 2011.Studies on the biosynthesis of the stephacidin and notoamide natural products: a stereochemicaland genetic conundrum.  Isr. J. Chem.  51(3): 442-452.  PubMed link

Gu, L., Eisman, E.B., Dutta, S., Franzmann, T.M., Walter, S., Gerwick, W.H>., Skiniotis, G.,Sherman, D.H. 2011.Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect.  Angew. Chem. Intl. Engl.  50(12): 2795-2798.  PubMed link

Lee, J.Y., Passalacqua, K.D., Hanna, P.C., Sherman, D.H. 2011. Regulation of petrobactin and bacillibactin biosynthesis in Bacillus anthracis under iron and oxygen variation.  PLos One.  6(6): e20777. PubMed link

McAfoos, T.J., Li, S., Tsukamoto, S., Sherman, D.H., Williams, R.M. 2011. Studies on the biosynthesis of the notoamides: total synthesis of notoamide s.  Heterocycles  82(1): 461-472.  PubMed link

Mortison, J.D.,Sherman, D.H., 2010. Frontiers and opportunities in chemoenzymatic synthesis.  J. Org. Chem. 75(21): 7041-7051. PubMed link

Buchholz, T.J., Rath, C.M., Lopanik, N.B., Gardner, N.P., Hakansson, K., Sherman, D.H. 2010. Polyketide beta-branching in bryostatin biosynthesis: identification of surrogate acetyl-ACP donors for BryR, an HMG-ACP synthase.  Chem. Biol.  17(10): 1092-1100.  PubMed link

Himpsl, S.D., Pearson, M.M., Arewang, C., Nusca, T.D.,Sherman, D.H., Mobley, H.L. 2010. Proteobactin and a yersiniabactin-related siderophore mediate iron acquisition in Proteus mirabilis.  Mol. Microbiol.  78(1): 138-157. PubMed link

Ding, Y., de Wet J.R., Cavalcoli, J., Li, S., Greshock, T.J., Miller, K.A., Finefield, J.M., Sunderhaus, J.D., McAfoos, T.J., Tsukamoto, S., Williams, R.M.,Sherman, D.H., 2010. Genome-based characterization of two prenylation steps in the assembly of the stephacidin and notoamide anticancer agents in a marine-derived Aspergillus sp.  J. Am. Chem. Soc.  132(36): 12733-12740. PubMed link

Khare, D., Wang, B., Gu, L., Razelun, J., Sherman, D.H., Gerwick, W.H., Hakansson, K., Smith, J.L. 2010. Conformational switch triggered by {alpha}- ketoglutarate in a halogenase of curacin A biosynthesis.  Proc. Natl. Acad. Sci U.S.A.  107(32): 14099-14104. PubMed link

Scaglione, J.B., Akey, D.L, Sullivan, R., Kittendorf, J.D., Rath, C.M., Kim, E.S. Smith, J.L. Sherman, D.H. 2010. Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase. Angew. Chem. Intl. Ed. Engl.  49(33): 5726-5730. PubMed link

Jones, A.C., Monroe, E.A, Eisman, E.B., Gerwick, L., Sherman, D.H., Gerwick, W.H.2010. The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria.  Nat. Prod. Rep.  27(7):1048-1065. PubMed link

Carlson, J.C., Fortman, J.L., Anzai, Y., Li, S., Burr, D.A.,Sherman, D.H. 2010. Identification of the tirandamycin biosynthetic gene cluster from Streptomyces sp. 307-309. ChemBioChem. 11(4):564-572. PubMed link

Tsukada, S.I., Anzai, Y., Li, S., Kinoshita, K., Sherman, D.H., Kato, F.2010.Targeting for O-methyltransferase genes, mycE and mycF, on the chromosome of Micromonospora griseorubida producing mycinamicin with a disruption cassette containing the bacteriophage phiC31 attB attachment site.  FEMS Microbiol. Lett.  304(2):148-156. PubMed link

Carlson, P.E. Jr., Dixon, S.D., Janes, B.K., Carr, K.A., Nusca, T.D., Anderson, E.C., Keene, S.E., Sherman, D.H., Hanna, P.C. 2010. Genetic analysis of petrobactin transport in Bacillus anthracis.  Mol. Microbiol.  75(4): 900-909. PubMed link

Akey, D.L., Razelun, J.R., Tehranisa, J., Sherman, D.H. Gerwick, W.H., Smith, J.L.2010. Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway. Structure. 18(1):94-105. PubMed link

Carlson, J.C., Li, S., Burr, D.A.,Sherman, D.H. 2009. Isolation and characterization of tirandamycins from a marine-derived Streptomyces spJ. Nat. Prod.  72(11):2076-2079. PubMed link

Sherman, D.H. 2009. Biochemistry; Enzyme's black box cracked open. Nature 461(7267):1068-1069. PubMed link

Gu, L., Wang, B., Kulkamid, A., Gehret, J.J., Lloyd, K.R., Gerwick, L., Gerwick, W.H., Wipf, P., Hakansson, K., Smith, J.L., Sherman, D.H. 2009. Polyketide Decarboxylative Chain Termination Preceded by O-Sulfonation in Curacin A Biosynthesis. J. Am. Chem. Soc. 131(44); 16033-16035. PubMed link

Yan, J., Gupta, S., Sherman, D. H. and Reynolds, K. A. 2009. Functional dissection of a multimodular polypeptide of the pikromycin polyketide synthase into monomodules using a matched pair of heterologous docking domains. ChemBioChem. 10:1537-1543. PubMed link

Li, S., Chaulagain, M.F., Knauff, A.R., Podust, L.M., Montgomery, J., and Sherman, D.H. 2009. Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase. Proc. Natl. Acad.. Sci.  106(44): 18463-18468. PubMed link

Mortison, J.D., Kittendorf, J.D., Sherman, D.H. 2009. Synthesis and Biochemical Analysis of Complex Chain-Elongation Intermediates for Interrogation of Molecular Specificity in the Erythromycin and Pikromycin Polyketide Synthases. J. Am. Chem. Soc. 131(43):15784-15793. PubMed link

Kim, B.G., Lee, M.J., Seo, J., Hwang, Y. B., Lee, M.Y., Han, K., Sherman, D.H., Kim, E.-S. 2009. Identification of functionally clustered nystatin-like biosynthetic genes in a rare actinomycetes, Pseudonocardia autotrophica. J. Ind. Microbiol. Biotechnol. 36(11): 1425-1434. PubMed link

Li, M.H, Ung, P.M., Zajkowski, J., Garneau-Tsodikova, S., and Sherman, D.H. 2009. Automated genome mining for natural products. BMC Bioinformatics. 10:185. PubMed link

Gu, L., Wang, B., Kulkarni, A., Geders, T.W., Grindberg, R.V., Gerwick, L., Hakansson, K., Wipf, P., Smith, J.L., Gerwick, W.H., Sherman, D.H. 2009. Metamorphic enzyme assembly in polyketide diversification. Nature. 459(7247): 731-735. PubMed link

Yan, J. Gupta, S., Sherman, D.H., Reynolds, K.A. 2009. Functional Dissection of a Multimodular Polypeptide of the Pikromycin Polyketide Synthase into Monomodules by Using a Matched Pair of Heterologous Docking Domains. ChemBioChem. 10(9):1537-1543. PubMed link

Hu, P.J., Sherman, D.H. 2009. DANSing with Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 106(19):7685-7686. PubMed link

Li, S., Anzai, Y., Kinoshita, K., Kato, F., Sherman, D.H. 2009. Functional Analysis of MycE and MycF: Two O-Methlytransferases Involved in the Biosynthesis of Mycinamicin Macrolide Antibiotics. ChemBioChem. 10(8):1297-1301. PubMed link

Park, S.H., Choi, S.S., Kim, Y.J., Chang, Y.K., Sherman, D.H., Kim, E.-S. 2009. Functional expression of SCO7832 stimulates tautomycetin production via pathway-specific regulatory gene overexpression in Streptomyces sp. CK4412. J. Ind. Microbiol. Biotechnol. 36(7):993-998.   PubMed link

Jones, A.C., Gu, L.., Sorrels, C.M., Sherman, D. H., Gerwick, W.H.. 2009. New tricks from ancient algae:natural products biosynthesis in marine cyanobacteria. Curr. Opin. Chem. Biol.,13(2):216-223. PubMed link

Sharp, K., Arthur, K.E., Gu, L., Ross, C., Harrison, G., Gunasekera, S.P., Meickle, T., Matthew, S. Luesch, H., Thacker, R.W., Sherman, D. H., Paul, V.J. 2009. Phylogenetic and chemical diversity of three chemotypes of bloom-forming Lyngbya (Cyanobacteria: Oscillatories) from reefs of Southeast Florida. Appl. Environ. Microbiol., 75(9): 2879-2888. PubMed link

Chamberland, S., Gruschow, S., Sherman, D. H., and Williams, R.M. 2009. Synthesis of Potential Early-Stage Intermediates in the Biosynthesis of FR900482 and Mitomycin C. Org. Letters. 11(4): 791-794. PubMed link

Buchholz, T.J., Geders, T.W., Bartley, F.E. 3rd, Reynolds, K.A., Smith, J.L., and Sherman D. H. 2009. Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains. Chem. Biol. 4(1):41-52.PubMed link

Li, S., Ouellet, H., Sherman, D.H., Podust, L.M. 2009. Analysis of transient and catalytic desosamine binding pockets in cytochrome P450 PikC from Streptomyces venezuelae. J. Biol. Chem. 284(9): 5723-5730. PubMed link

Kittendorf, J. D. and Sherman,D.H, Williams, R.M. 2008. The methymycin/pikromycin biosynthetic pathway: A model for metabolic diversity in natural product biosynthesis. Bioorg. & Med. Chem. 17(6): 2137-2146. PubMed link

Lopanik, N. B., Shields, J. A., Buchholz, T. J., Rath, C. M., Hothersoll, J., Haygood, M. G., Håkansson, K., Thomas, C. M., and Sherman, D. H. 2008. In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont. Chem. Biol. 15(11): 1175-1186. PubMed link

Pfleger, B.F., Kim, Y., Nusca, T.D., Maltseva, N., Lee, J.Y., Rath, C.M., Scaglione, J.B., Janes, B.K., Anderson, E.C., Bergman, N.H., Hanna, P.C., Joachimiak, A., Sherman, D.H. 2008. Structural and functional analysis of AsbF: origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis.Proc. Natl. Acad. Sci. 105(44): 17133-17138. PubMed link

Ding, Y., Greshock, T.J., Miller, K.A., and Sherman,.D.H, Williams, R.M. 2008. Premalbrancheamide:Synthesis, Isotopic Labeling, Biosynthetic Incorporation, and Detection in Cultures of Malbranchea aurantiaca Org. Letters (10)21:4863-4866.  PubMed link

Hur, Y. A., Choi, S.S.,and Sherman,.D.H, Kim, E.-S.2008. Identification of TmcN as a pathway-specific positive regulator of tautomycetin biosynthesis in Streptomyces sp. CK4412. Microbiology 154(Pt10): 2912-2919.  PubMed link

Anzai, Y., Li, S., Chaulagain, M. R., Kinoshita, K., Kato, F., Montgomery, J., and Sherman D. H., 2008. 2008. Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics Chem. Biol. 15(9):950-959. PubMed link

Smith, J. L. and Sherman D. H., 2008. An enzyme assembly line. Science 321(5894):1304-1305.  Science Link

Ding, Y., Gruschow, S., Greshock, T.J., Finefield, J.M., Sherman D. H., Williams, R.M. 2008. Detection of VM55599 and Preparaherquamide from Aspergillus japonicus and, Penicillium fellutanum: Biosynthetic Implications. J. Nat. Prod. 71(9): 1574-1578. PubMed link

Jayapal K.P., Philp R.J., Kok Y.J., Yap M.G., Sherman D. H. ,Griffin T.J., and Hu W.-S. 2008. Uncovering genes with divergent mRNA-protein dynamics in Streptomyces coelicolor. PLoS ONE. 3(5):e2097. PubMed link

Ding Y., Williams R.M., and Sherman D. H. 2008. Molecular analysis of a 4-dimethylallyltryptophan synthase from malbranchea aurantiaca. J. Biol. Chem. 283(23):16068-16076. PubMed link

Ding Y., Seufert W., Beck Z.Q., and Sherman D. H. 2008. Analysis of the cryptophycin P450 epoxidase reveals substrate tolerance and cooperativity. J. Amer. Chem. Soc. 130(16):5492-5498. PubMed link

Miller K.A., Welch T.R., Greshock T.J.,Ding Y., Sherman D. H., and Williams R.M. 2008. Biomimetic total synthesis of malbrancheamide and malbrancheamide B. J. Org. Chem. 73(8):3116-3119. PubMed link

Lian W., Jayapal K.P., Charaniya S., Mehra S., Glod F., Kyung Y. S., Sherman D. H., and Hu W.-S. 2008. Genome-wide transcriptome analysis reveals that a pleiotropic antibiotic regulator, AfsS, modulates nutritional stress response in Streptomyces coelicolor A3(2). BMC Genomics, Jan 29;9(1): 56.) PubMed link

Lee J.Y., Sherman D.H. , and Hwang B. K. 2008. In vitro antimicrobial and in vivo antioomycete activities of the novel antibiotic thiobutacin. Pest. Manag. Sci. 64(2):172-177. PubMed link

Buchholz T.J., Kittendorf J.D., and Sherman D. H. 2007. Polyketide biosynthesis, modular polyketide synthases. Wiley Encyclopedia of Chemical Biology.

Gu L.C., Geders T.W., Wang B., Gerwick W.H., Håkansson K., Smith J. L., and Sherman D.H.. 2007. GNAT-like strategy for polyketide chain initiation. Science 318(5852):970-974. Link to Science Magazine

Geders T.W., Gu L.C., Mowers J.C., Liu H., Gerwick W.H., Håkansson K., Sherman D. H. , Smith J.L. 2007. Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula: Insights into a decarboxylase involved in polyketide chain b-branching. J. Biol. Chem. 282(49): 35954-35963. PubMed link

Li S., Podust L.M., and Sherman D. H. 2007. Engineering and analysis of a self-sufficient biosynthetic cytochrome P450 PikC fused to the RhFRED reductase domain. J. Amer. Chem. Soc. 129: 12940-12941. PubMed link

Seufert W., Beck Z.Q., and Sherman D. H. 2007. Enzymatic release and macrolactonization of cryptophycins from safety-catch solid support. Angewandte Chemie 46: 9298-9300. PubMed link

Kittendorf J. D., Beck B. J., Buchholz T. J. and Sherman D. H. 2007. Interrogating the molecular basis for multiple macrolactone ring formation by the pikromycin polyketide synthase. Chemistry & Biology 14: 944-954. PubMed link

Beck Z. Q., Burr D. A. and Sherman D. H. 2007. Characterization of the b-methylaspartate-a-decarboxylase (CrpG) from the cryptophycin biosynthetic pathway. ChemBioChem 8(12): 1373-1375. PubMed link

Jayapal, K.P., Lian, W., Glod, F., Sherman, D.H. and Hu, W.S. 2007. Comparative genomic hybridizations reveal absence of large Streptomyces coelicolor genomic islands in Streptomyces lividans. BMC Genomics 2007 Jul 10;8(1):229. PubMed link

Oh, H.-S., Yun, J.-S., Nah, K.-H., Kang, H.-Y. and Sherman D. H. Synthesis of the tetraketide lactones from the pikromycin biosynthetic pathway. Eur. J. Org. Chem. 2007 3369–3379.

Sitachitta N., Lopanik N. B., Mao, Y., Sherman D.H. 2007. Analysis of a parallel branch in the mitomycin biosynthetic pathway involving the mitn-encoded aziridine n-methyltransferase. J. Biol. Chem. 2007.  Jul 20;282(29):20941-7. PubMed link

Kwon S. J., Lee M.-Y., Ku B., Sherman D. H., and Dordick J. S.. 2007. High-throughput, microarray-based Synthesis of natural product Analogs via in vitro metabolic pathway construction. ACS Chemical Biology 2007 May 25. PubMed link

Grüschow S., Chang L.C., Mao Y., and Sherman D.H. 2007. Hydroxyquinone O-methylation in mitomycin biosynthesis. J. Amer. Chem. Soc. 129:6470-6476. PubMed link

Grüschow S., Buchholz T.J., Seufert W., Dordick J.S., and Sherman D.H. 2007. Substrate profile analysis and ACP-mediated acyl transfer in Streptomyces coelicolor type III polyketide synthases. Chembiochem. 8:863-868. PubMed link

Passalacqua K.D., Bergman N.H., Lee J.Y., Sherman D.H., and Hanna P.C. 2007. The global transcriptional responses of Bacillus anthracis Sterne (34F2) and dsodA1 to paraquat reveal metal ion homeostasis imbalances during endogenous superoxide stress. J Bacteriol. 189:3996-4013 .PubMed link

Liu H., Håkansson K., Lee J.Y., and Sherman D.H. 2007. Collision-activated dissociation, infrared multiphoton dissociation, and electron capture dissociation of the Bacillus anthracis siderophore petrobactin and its metal ion complexes. Journal of the American Society for Mass Spectrometry 18:842-849. PubMed link

Choi, S.-S., Hur, Y.-A., Sherman, D.H., and E.-S. Kim. 2007. Isolation of the biosynthetic gene cluster for tautomycetin, a linear polyketide T cell-specific immunomodulator from Streptomyces sp. CK4412. Microbiology 153:1095-1102. PubMed link

Pfleger B. F., Lee, J.Y., Somu, R.V., Aldrich, C.C., Hanna, P.C., and D. H. Sherman. 2007. Characterization and analysis of early enzymes for petrobactin biosynthesis in Bacillus anthracis. Biochemistry 46:4147-4157. PubMed link

Li, S., Grüschow, S., Dordick, J.S., and Sherman, D.H. 2007. Molecular analysis of the role of tyrosine 224 in the active site of Streptomyces coelicolor RppA, a bacterial type III polyketide synthase. J. Biol. Chem. 46(13): 4147-4157. Link

Sudek S., Lopanik N.B., Waggoner L.E., Hildebrand M., Anderson C., Liu H., Patel A., Sherman, D.H. and Haygood M.G. 2007. Identification of the putative bryostatin polyketide synthase gene cluster from “Candidatus Endobugula sertula”, the uncultivated microbial symbiont of the marine bryozoan Bugula neritina. J. Nat. Prod. 70:67-74. PubMed link

Lee J.Y., Janes B.K., Passalacqua K.D., Pfleger B., Bergman N.H., Liu H., Håkansson K., Somu R.V., Aldrich C.C., Cendrowski S., Hanna P.C., Sherman, D.H. 2007. Biosynthetic analysis of the petrobactin siderophore pathway from Bacillus anthracis. J. Bacteriol. 189:1698-1710. PubMed link

Magarvey N.A., Beck Z.Q., Golakoti T., Ding Y., Huber U., Hemscheidt T.K., Abelson D., Moore R.E., and Sherman D.H. 2006. Biosynthetic characterization and chemoenzymatic assembly of the cryptophycins. Potent anticancer agents from Nostoc cyanobionts. ACS Chem. Biol. 1:766-779. Link

Venkatraman, L, Salomon, C.E., Sherman, D.H., Fecik, R.A. 2006. Total synthesis of narbonolide and biotransformation to pikromycin. J. Org. Chem Note 71:9853-9856. PubMed link

Kittendorf, J.D., Sherman, D. H. (2006). Developing tools for engineering hybrid polyketide synthetic pathways.Curr Opin Biotechnol. 17:597-605. PubMed link

Giraldes, J.W., Akey, D.L., Kittendorf, J.D., Sherman, D.H. , Smith, J.L., Fecik, R.A. 2006. Structural and mechanistic insights of polyketide macrolactonization from polyketide-based affinity labels. Nature Chemical Biology. 2:531-536. PubMed link

Akey, D.L., Kittendorf, J.D., Giraldes, J.W., Fecik, R.A., Sherman, D.H. , Smith, J.L. 2006. Structural basis for macrolactonization by the pikromycin thioesterase. Nature Chemical Biology. 2:537-542. PubMed link

Sherman, D.H. and Smith, J.L. 2006. Clearing the skies over modular polyketide synthases. ACS Chem. Biol. 1:505-509. PubMed link

Sherman, D.H. ; Li, S.; Yermalitskaya, L.V.; Kim, Y.; Smith, J.A.; Waterman, M.R.; Podust, L.M. 2006. The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae. J Biol Chem. 281(36):26289-97. PubMed link

Ku, B.; Cha, J.; Srinivasan, A.; Kwon, S.J.; Jeong, J.C.; Sherman, D.H. ; Dordick, J.S. 2006. Chip-based polyketide biosynthesis and functionalization. Biotechnol Prog. 22(4):1102-7. PubMed link

Beck, Z. Q., & Sherman, D. H. (2006). Development of an internally quenched fluorogenic substrate for kinetic analysis of thioesterases. Analytical Biochemistry, 349, 309-311. PubMed link

Mehra, S., Lian, W., Jayapal, K. P., Charaniya, S. P., Sherman, D. H., & Hu, W. S. (2006). A framework to analyze multiple time series data: A case study with Streptomyces coelicolor. Journal of Industrial Microbiology & Biotechnology, 33, 159-172. PubMed link

Lee, S. K., Park, J. W., Kim, J. W., Jung, W. S., Park, S. R., Choi, C. Y., Kim, E. S., Kim, B. S., Ahn, J. S., Sherman, D. H., & Yoon, Y. J. (2006). Neopikromycin and novapikromycin from the pikromycin biosynthetic pathway of Streptomyces venezuelae. Journal of Natural Products, 69, 847-849. PubMed link

Flatt, P. M., O'Connell, S. J., McPhail, K. L., Zeller, G., Willis, C. L., Sherman, D. H., & Gerwick, W. H. (2006). Characterization of the initial enzymatic steps of barbamide synthesis. Journal of Natural Products, 69, 938-944. PubMed link

Jung WS, Lee SK, Hong JS, Park SR, Jeong SJ, Han AR, Sohng JK, Kim BG, Choi CY, Sherman DH, Yoon YJ. 2006. Heterologous expression of tylosin polyketide synthase and production of a hybrid bioactive macrolide in Streptomyces venezuelae. Appl Microbiol Biotechnol. 72(4):763-9. PubMed link

Nishizawa, T., Gruschow, S., Jayamaha, D. H. E., Nishizawa-Harada, C., & Sherman, D. H. (2006). Enzymatic assembly of the bis-indole core of rebeccamycin. Journal of the American Chemical Society, 128, 724-725. PubMed link

Gu, L. C., Jia, J. Y., Liu, H. C., Hakansson, K., Gerwick, W. H., & Sherman, D. H. (2006). Metabolic coupling of dehydration and decarboxylation in the curacin A pathway: Functional identification of a mechanistically diverse enzyme pair. Journal of the American Chemical Society, 128, 9014-9015. PubMed link

Articles (1997-2005)

Beck, Z. Q., Aldrich, C. C., Magarvey, N. A., Georg, G. I., & Sherman, D. H. (2005). Chemoenzymatic synthesis of cryptophycin/arenastatin natural products. Biochemistry, 44, 13457-13466. PubMed link

Nishizawa, T., Aldrich, C. C., & Sherman, D. H. (2005). Molecular analysis of the rebeccamycin L-amino acid oxidase from Lechevalieria aerocolonigenes ATCC 39243. Journal of Bacteriology, 187, 2084-2092. PubMed link

Venkatraman, L., Aldrich, C. C., Sherman, D. H., & Fecik, R. A. (2005). Formal total synthesis of the polyketide macrolactone narbonolide. Journal of Organic Chemistry, 70, 7267-7272. PubMed link

Jeong, J. C., Srinivasan, A., Grüschow, S., Bach, H., Sherman, D. H., & Dordick, J. S. (2005). Exploiting the reaction flexibility of a type III polyketide synthase through in vitro pathway manipulation. Journal of the American Chemical Society, 127, 64-65. Pub Med Link

Aldrich, C. C., Beck, B. J., Fecik, R. A., & Sherman, D. H. (2005). Biochemical investigation of pikromycin biosynthesis employing native penta- and hexaketide chain elongation intermediates. Journal of the American Chemical Society, 127, 8441-8452. PubMed link

Aldrich, C. C., Venkatraman, L., Sherman, D. H., & Fecik, R. A. (2005). Chemoenzymatic synthesis of the polyketide macrolactone 10-deoxymethynolide. Journal of the American Chemical Society, 127, 8910-8911. PubMed link

Magarvey, N. A., Keller, J. M., Bernan, V., Dworkin, M., & Sherman, D. H. (2004). Isolation and characterization of novel marine-derived actinomycete taxa rich in bioactive metabolites. Applied and Environmental Microbiology, 70, 7520-7529. Pub Med Link

Srinivasan A., Bach H., Sherman, D. H., & Dordick, J. S. (2004). Bacterial P450-catalyzed polyketide hydroxylation on a microfluidic platform. Biotechnology & Bioengineering, 88, 528-535. Pub Med Link

Hildebrand, M., Waggoner, L. E., Liu, H. B., Sudek, S., Allen, S., Anderson, C., Sherman, D. H., & Haygood, M. (2004). bryA: An unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritina. Chemistry & Biology, 11, 1543-1552. Pub Med Link

Chang, Z. X., Sitachitta, N., Rossi, J. V., Roberts, M. A., Flatt, P. M., Jia, J. Y., Sherman, D. H., & Gerwick, W. H. (2004). Biosynthetic pathway and gene cluster analysis of curacin A, an anti-tubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula. Journal of Natural Products, 67, 1356-1367. Pub Med Link

Kim, B. S., Sherman, D. H., & Reynolds, K. A.(2004). An efficient method for creation and functional analysis of libraries of hybrid type I polyketide synthases. Protein Engineering, Design and Selection, 17, 277-284. Pub Med Link

Podust, L. M., Bach, H., Kim, Y., Lamb, D. C., Arase, M., Sherman, D. H., Kelly, S. L., & Waterman, M. R. (2004). Comparison of the 1.85 A structure of CYP154A1 from Streptomyces coelicolor A3(2) with the closely related CYP154C1 and CYPs from antibiotic biosynthesis pathways. Protein Science, 13, 255-268.

Podust, L. M., Kim, Y., Arase, M., Neely, B. A., Beck, B. J., Bach, H., Sherman, D. H., Lamb, D. C., Kelly, S. L., & Waterman, M. R. (2003). The 1.92-angstrom structure of Streptomyces coelicolor A3(2) CYP154C1 - A new mono-oxygenase that functionalizes macrolide ring systems. Journal of Biological Chemistry, 278, 12214-12221.

Jung, W. S., Kim, E. S., Kang, H. Y., Choi, C. Y., Sherman, D. H., & Yoon, Y. J. (2003). Site-directed mutagenesis on putative macrolactone ring size determinant in the hybrid pikromycin-tylosin polyketide synthase. Journal of Microbiology and Biotechnology, 13, 823-827.

Beck, B. J., Aldrich, C. C., Fecik, R. A., Reynolds, K. A., & Sherman, D. H. (2003). Iterative chain elongation by a pikromycin monomodular polyketide synthase. Journal of the American Chemical Society, 125, 4682-4683. Pub Med Link

Beck, B. J., Aldrich, C. C., Fecik, R. A., Reynolds, K. A., & Sherman, D. H. (2003). Substrate recognition and channeling activities of monomodules from the pikromycin polyketide synthase. Journal of the American Chemical Society, 125, 12551-12557. Pub Med Link

Kim, B. S., Cropp, T. A., Florova, G., Lindsay, Y., Sherman, D. H., & Reynolds, K. A. (2002). An unexpected interaction between the modular polyketide synthases, erythromycin DEBS1 and pikromycin PikAIV, leads to efficient triketide lactone synthesis. Biochemistry, 41, 10827-10833. Abstract

Baumann, R. P., Sherman, D. H., & Sartorelli, A. C. (2002). Novel selection marker for mammalian cell transfection. BioTechniques, 32, 1030-1036. Abstract

Yoon, Y. J., Beck, B. J., Kim, B. S., Kang, H. Y., Reynolds, K. A., & Sherman, D. H. (2002). Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae. Chemistry & Biology, 9, 203-214. Abstract

Beck, B. J., Yoon, Y. J., Reynolds, K. A., & Sherman, D. H. (2002). The hidden steps of domain skipping: Macrolactone ring size determination in the pikromycin modular polyketide synthase. Chemistry & Biology, 9, 575-583. Abstract

Chang, Z. X., Flatt, P., Gerwick, W. H., Nguyen, V. A., Willis, C. L., & Sherman, D. H. (2002). The barbamide biosynthetic gene cluster: A novel marine cyanobacterial system of mixed polyketide synthase (PKS) non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit. Gene, 296, 235-247. Abstract

Kim, B. S., Cropp, T. A., Beck, B. J., Sherman, D. H., & Reynolds, K. A. (2002). Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin. Journal of Biological Chemistry, 277, 48028-48034. Full Paper Link

Martin, T. W., Dauter, Z., Devedjiev, Y., Sheffield, P., Jelen, F., He, M., Sherman, D. H., Otlewski, J., Derewenda, Z. S., & Derewenda, U. (2002). Molecular basis of mitomycin C resistance in Streptomyces: Structure and function of the MRD protein. Structure, 10, 933-942. Pub Med Link

Kyung, Y. S., Sherman, D. H., & Hu, W. S. (2001). Simultaneous analysis of spatio-temporal gene expression for cephamycin biosynthesis in Streptomyces clavuligerus. Biotechnology Progress, 17, 1000-1007. Abstract

Baumann, R. P., Hodnick, W. F., Seow, H. A., Belcourt, M. F., Rockwell, S., Sherman, D. H., & Sartorelli, A. C. (2001). Reversal of mitomycin C resistance by overexpression of bioreductive enzymes in Chinese hamster ovary cells. Cancer Research, 61, 7770-7776. Pub Med Link

Chen, S., Roberts, J. B., Xue, Y. Q., Sherman, D. H., & Reynolds, K. A. (2001). The Streptomyces venezuelae pikAV gene contains a transcription unit essential for expression of enzymes involved in glycosylation of narbonolide and 10-deoxymethynolide. Gene, 263, 255-264. Abstract

Wilson, D. J., Xue, Y. Q., Reynolds, K. A., & Sherman, D. H. (2001). Characterization and analysis of the PikD regulatory factor in the pikromycin biosynthetic pathway of Streptomyces venezuelae. Journal of Bacteriology, 183, 3468-3475. Full Paper Link

Penketh, P. G., Hodnick, W. F., Belcourt, M. F., Shyam, K., Sherman, D. H., & Sartorelli, A. C. (2001). Inhibition of DNA cross-linking by mitomycin C by peroxidase-mediated oxidation of mitomycin C hydroquinone. Journal of Biological Chemistry, 276, 34445-34452. Full Paper Link

Varoglu, M., Mao, Y. Q., & Sherman, D. H. (2001). Mapping the mitomycin biosynthetic pathway by functional analysis of the MitM aziridine N-methyltransferase. Journal of the American Chemical Society, 123, 6712-6713. Pub Med Link

Kyung, Y. S., Hu, W. S., & Sherman, D. H. (2001). Analysis of temporal and spatial expression of the CcaR regulatory element in the cephamycin C biosynthetic pathway using green fluorescent protein. Molecular Microbiology, 40, 530-541. Pub Med Link

He, M., Sheldon, P. J., & Sherman, D. H. (2001). Characterization of a novel quinone reductase activity for the mitomycin C binding protein (MRD): Functional switching from a drug-activating enzyme to a drug-binding protein. Proceedings of the National Academy of Sciences of the USA, 98, 926–931. Pub Med Link

Kim, S. J., Kang, H. Y., & Sherman, D. H. (2001). Synthesis of triketide delta-lactones. Synthesis, 12, 1790-1793.

Chen, S., Xue, Y. Q., Sherman, D. H., & Reynolds, K. A. (2000). Mechanisms of molecular recognition in the pikromycin polyketide synthase. Chemistry & Biology, 7, 907-918. Pub Med Link

Xue, Y. Q., Wilson, D., & Sherman, D. H. (2000). Genetic architecture of the polyketide synthases for methymycin and pikromycin series macrolides. Gene, 245, 203-211. Pub Med Link

He, M., Varoglu, M., & Sherman, D. H. (2000). Structural modeling and site-directed mutagenesis of the actinorhodin beta-ketoacyl-acyl carrier protein synthase. Journal of Bacteriology, 182, 2619-2623. Full Paper Link

Khetan, A., Hu, W. S., & Sherman, D. H. (2000). Heterogenous distribution of lysine 6-aminotransferase during cephamycin C biosynthesis in Streptomyces clavuligerus demonstrated using green fluorescent protein as a reporter. Microbiology, 146, 1869-1880. Full Paper Link

Xue, Y. Q., & Sherman, D. H. (2000). Alternative modular polyketide synthase expression controls macrolactone structure. Nature, 403, 571-575. Pub Med Link

Khetan, A., Malmberg, L. H., Kyung, Y. S., Sherman, D. H., & Hu, W. S. (1999). Precursor and cofactor as a check valve for cephamycin biosynthesis in Streptomyces clavuligerus. Biotechnology Progress, 15, 1020-1027. Pub Med Link

Mao, Y. Q., Varoglu, M., & Sherman, D. H. (1999). Genetic localization and molecular characterization of two key genes (mitAB) required for biosynthesis of the antitumor antibiotic mitomycin C. Journal of Bacteriology, 181, 2199-2208. Pub Med Link

Sheldon, P. J., Mao, Y. Q., He, M., & Sherman, D. H. (1999). Mitomycin resistance in Streptomyces lavendulae includes a novel drug-binding protein-dependent export system. Journal of Bacteriology, 181, 2507-2512. Pub Med Link

Zhao, L. S., Ahlert, J., Xue, Y. Q., Thorson, J. S., Sherman, D. H., & Liu, H. W. (1999). Engineering a methymycin/pikromycin calicheamicin hybrid: Construction of two new macrolides carrying a designed sugar moiety. Journal of the American Chemical Society, 121, 9881-9882.

Han, L., Khetan, A., Hu, W. S., & Sherman, D. H. (1999). Time-lapsed confocal microscopy reveals temporal and spatial expression of lysine epsilon-aminotransferase gene in Streptomyces clavuligerus. Molecular Microbiology, 34, 878-886. Pub Med Link

Borisova, S. A., Zhao, L. S., Sherman, D. H., & Liu, H. W. (1999). Biosynthesis of desosamine: Construction of a new macrolide carrying a genetically designed sugar moiety. Organic Letters, 1, 133-136. Pub Med Link

Belcourt, M. F., Penketh, P. G., Hodnick, W. F., Johnson, D. A., Sherman, D. H., Rockwell, S., & Sartorelli, A. C. (1999). Mitomycin resistance in mammalian cells expressing the bacterial mitomycin C resistance protein MCRA. Proceedings of the National Academy of Sciences of the USA, 96, 10489-10494. Full Paper Link

Xue, Y. Q., Wilson, D., Zhao, L. S., Liu, H. W., & Sherman, D. H. (1998). Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae. Chemistry & Biology, 5, 661-667. Pub Med Link

Bedeker, A., Zink, R. M., Sherman, D. H., Line, T. V., & Van Pilsum, J. F. (1998). The comparative amino acid sequences, substrate specificities and gene or cDNA nucleotide sequences of some prokaryote and eukaryote amidinotransferases: Implications for evolution. Comparative Biochemistry and Physiology, 119, 677-690. Pub Med Link

Zhao, L., Sherman, D. H., & Liu, H. W. (1998). Biosynthesis of desosamine: Molecular evidence suggesting ß-glucosylation as a self-resistance mechanism in methymycin/neomethymycin producing strain, Streptomyces venezuelae. Journal of the American Chemical Society, 120, 9374-9375.

Zhao, L. S., Sherman, D. H., & Liu, H. W. (1998). Biosynthesis of desosamine: Construction of a new methymycin/neomethymycin analogue by deletion of a desosamine biosynthetic gene. Journal of the American Chemical Society, 120, 10256-10257.

Zhao, L. S., Que, N. L. S., Xue, Y. Q., Sherman, D. H., & Liu, H. W. (1998). Mechanistic studies of desosamine biosynthesis: C-4 deoxygenation precedes C-3 transamination. Journal of the American Chemical Society, 120, 12159-12160.

Xue, Y. Q., Zhao, L. S., Liu, H. W., & Sherman, D. H. (1998). A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: Architecture of metabolic diversity. Proceedings of the National Academy of Sciences of the USA, 95, 12111-12116. Full Article Link

Sheldon, P. J., Johnson, D. A., August, P. R., Liu, H. W., & Sherman, D. H. (1997). Characterization of a mitomycin-binding drug resistance mechanism from the producing organism, Streptomyces lavendulae. Journal of Bacteriology, 179, 1796-1804. [Correction: 179, 4080.]

Johnson, D. A., August, P. R., Shackleton, C., Liu, H. W., & Sherman, D. H. (1997). Microbial resistance to mitomycins involves a redox relay mechanism. Journal of the American Chemical Society, 119, 2576-2577.

Articles (1989-1996)

Khetan, A., Malmberg, L. H., Sherman, D. H., & Hu, W. S. (1996). Metabolic engineering of cephalosporin biosynthesis in Streptomyces clavuligerus. Annals of the New York Academy of Sciences, 782, 17-24.

Williams, M. D., Rahn, J. A., & Sherman, D. H. (1996). Production of a polyhydroxyalkanoate biopolymer in insect cells with a modified eukaryotic fatty acid synthase. Applied and Environmental Microbiology, 62, 2540-2546. [Correction 64, 383.]

August, P. R., Rahn, J. A., Flickinger, M. C., & Sherman, D. H. (1996). Inducible synthesis of the mitomycin C resistance gene product (MCRA) from Streptomyces lavendulae. Gene, 175, 261-267.

Williams, M. D., Fieno, A. M., Grant, R. A., & Sherman, D. H. (1996). Expression and analysis of a bacterial poly(hydroxyalkanoate) synthase in insect cells using a baculovirus system. Protein Expression and Purification, 7, 203-211.

Malmberg, L. H., Hu, W. S., & Sherman, D. H. (1995). Effects of enhanced lysine epsilon-aminotransferase activity on cephamycin biosynthesis in Streptomyces clavuligerus. Applied Microbiology and Biotechnology, 44, 198-205.

Crosby, J., Sherman, D. H., Bibb, M. J., Revill, W. P., Hopwood, D. A., & Simpson, T. J. (1995). Polyketide synthase acyl carrier proteins from Streptomyces - Expression in Escherichia coli, purification and partial characterization. Biochimica et Biophysica Acta, 1251, 32-42.

Kim, E. S., Cramer, K. D., Shreve, A. L., & Sherman, D. H. (1995). Heterologous expression of an engineered biosynthetic pathway - Functional dissection of type II polyketide synthase components in Streptomyces species. Journal of Bacteriology, 177, 1202-1207.

Bibb, M. J., Sherman, D. H., Omura, S., & Hopwood, D. A. (1994). Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin. Gene, 142, 31-39.

Khosla, C., McDaniel, R., Ebert-Khosla, S., Torres, R., Sherman, D. H., Bibb, M. J., & Hopwood, D. A. (1993). Genetic construction and functional analysis of hybrid polyketide synthases containing heterologous acyl carrier proteins. Journal of Bacteriology, 175, 2197-2204.

Malmberg, L. H., Hu, W. S., & Sherman, D. H. (1993). Precursor flux control through targeted chromosomal insertion of the lysine epsilon-aminotransferase (LAT) gene in cephamycin C biosynthesis. Journal of Bacteriology, 175, 6916-6924.

Malmberg, L. H., Sherman, D. H., & Hu, W. S. (1992). Analysis of rate-limiting reactions in cephalosporin biosynthesis. Annals of the New York Academy of Sciences, 665, 16-26.

Sherman, D. H., Kim, E. S., Bibb, M. J., & Hopwood, D. A. (1992). Functional replacement of genes for individual polyketide synthase components in Streptomyces coelicolor A3(2) by heterologous genes from a different polyketide pathway. Journal of Bacteriology, 174, 6184-6190.

Arrowsmith, T. J., Malpartida, F., Sherman, D. H., Birch, A., Hopwood, D. A., & Robinson, J. A. (1992). Characterization of acti-homologous DNA encoding polyketide synthase genes from the monensin producer Streptomyces cinnamonensis. Molecular & General Genetics, 234, 254-264.

Sherman, D. H., Bibb, M. J., Simpson, T. J., Johnson, D., Malpartida, F., Fernandez-Moreno, M., Martinez, E., Hutchinson, C. R., & Hopwood, D. A. (1991). Molecular genetic analysis reveals a putative bifunctional polyketide cyclase dehydrase gene from Streptomyces coelicolor and Streptomyces violaceoruber, and a cyclase o-methyltransferase from Streptomyces glaucescens. Tetrahedron, 47, 6029-6043.

Sherman, D. H., Malpartida, F., Bibb, M. J., Kieser, H. M., & Hopwood, D. A. (1989). Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber TU22. EMBO Journal, 8, 2717-2725.

Review Articles

Fortman, J. L., & Sherman, D. H. (2005). Utilizing the power of microbial genetics to bridge the gap between the promise and the application of marine natural products. Chembiochem, 6, 960-978. PubMed link

Salomon, C. E., Magarvey, N. A., & Sherman, D. H. (2004). Merging the potential of microbial genetics with biological and chemical diversity: An even brighter future for marine natural product drug discovery. Natural Product Reports, 21, 105-121.

Cropp, T. A., Kim, B. S., Beck, B. J., Yoon, Y. J., Sherman, D. H., & Reynolds, K. A. (2002). Recent developments in the production of novel polyketides by combinatorial biosynthesis. Biotechnology & Genetic Engineering Reviews, 19, 159-172.

Xue, Y. Q., & Sherman, D. H. (2001). Biosynthesis and combinatorial biosynthesis of pikromycin-related macrolides in Streptomyces venezuelae. Metabolic Engineering, 3, 15-26.

Mao, Y. Q., Varoglu, M., & Sherman, D. H. (1999). Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564. Chemistry & Biology, 6, 251-263.

Editorial Material

Sherman, D. H. (2005). The lego-ization of polyketide biosynthesis. Nature Biotechnology, 23, 1083-1084. PubMed link

Sherman, D. H. (2002). New enzymes for "warheads". Nature Biotechnology, 20, 984-985.

Notes

Kim, E. S., Bibb, M. J., Butler, M. J., Hopwood, D. A., & Sherman, D. H. (1994). Sequences of the oxytetracycline polyketide synthase encoding OTC genes from Streptomyces rimosus. Gene, 141, 141-142.

Kim, E. S., Hopwood, D. A., & Sherman, D. H. (1994). Analysis of type II polyketide beta-ketoacyl synthase specificity in Streptomyces coelicolor A3(2) by trans complementatiion of actinorhodin synthase mutants. Journal of Bacteriology, 176, 1801-1804.

August, P. R., Flickinger, M. C., & Sherman, D. H. (1994). Cloning and analysis of a locus (MCR) involved in mitomycin C resistance in Streptomyces lavendulae. Journal of Bacteriology, 176, 4448-4454.

Stork, G., & Sherman, D. H. (1982). Efficient de novo construction of the indanpropionic acid precursor of 11-keto steroids - An improved internal diels-alder sequence. Journal of the American Chemical Society, 104, 3758-3759.