Scientific Cores & Resources
Center for Chemical Genomics
The CCG is a collaboratory employing high throughput robotic screening and other approaches to explore biological questions with the power of chemical diversity.
Center for Chemical Genomics website
Center for Structural Biology
The Center for Structural Biology (CSB) provides a comprehensive structural biology capability to researchers at the University of Michigan. Tools available to the CSB include an X-ray facility to determine crystal structures of biological molecules, high-Throughput Protein Laboratory for protein engineering, and a Crystallization Screening Laboratory. The Center has a programmatic collaboration with the Center for Chemical Genomics (CCG) in which structures can be determined of target proteins in complex with compounds identified in high-throughput screens in the CCG.
Center for Structural Biology website
Center for Stem Cell Biology
The CSCB facilitates interdisciplinary research in the fundamental biology of stem cell science across the U-M campus.
Center for Stem Cell Biology website
DNA Sequencing Core
The University of Michigan's DNA Sequencing Core provides U-M investigators access to automated DNA sequencing technology on a recharge basis. The Core processes samples primarily on a pair of ABI Model 3730 sequencers, with a Model 3700 occasionally used for backup capacity. Samples are typically processed in 2 business days, and yield 700-900 nucleotides of high-quality DNA sequence data. It is located on the third floor of LSI, room 3266.
Flow Cytometry Core
The Flow Cytometry Core laboratory provides flow cytometry instrumentation and expertise to University of Michigan investigators—and the surrounding biotech community—in a broad range of basic and medical science disciplines. Samples are prepared by individual investigators, who then deliver samples to the Core for flow cytometric analysis or cell sorting. The Core also provides assistance in grant and publication preparation, publication-quality graphics, and development of experimental designs. It is located on the third floor of LSI, room 3222.
Email: davadams at med.umich.edu
Functional Genomic Core
The University of Michigan shRNA core facility provides both the entire human and mouse shRNA libraries, which will provide genome-wide coverage for their respective models, typically providing multiple constructs for most targeted genes. It is located on the third floor of LSI, room 3328.
Metabolic Phenotyping Core
The Metabolic Phenotyping Core is one of the core laboratories of the Michigan Metabolomics and Obesity Center (MMOC). It provides user-friendly help in the design and execution of studies using rat and mouse models of diabetes, obesity and related metabolic disorders. It is located on the third floor of LSI, room 3338.
Email: nathanqui at med.umich
The first floor of the Life Sciences Institute is devoted to a state-of-the-art 36,000 square foot vivarium for small animals and fish. Facilities include ample quarantine areas and procedure rooms that eliminate the need to carry animals throughout the building. It is directed by Board Certified Laboratory Animal Medicine Veterinarians and staffed with certified laboratory animal technicians and is accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC).
Housed in the 3rd floor of the LSI, the Varian 600 MHz NMR is a modern, high-end active-shielded instrument suitable for biomolecule structural analysis. There is also a CapNMR Probe (Protasis) which allows unprecedented reduction in sample volume for NMR analysis, which reduces solvent usage and permits detection of small quantities of organic molecules. As envisioned, this system provides rapid structural determination of compounds from HPLC fractions in high throughput.
Cryo-Electron Microscopy Laboratory
Located on the first floor of the LSI is a 3,200 square feet suite dedicated to cryo-electron microscopy. Cryo-EM provides high resolution images of biological specimens free of the distortions that specimen preparation for traditional electron microscopy can cause. The facility includes a 120 kV and 200 kV electron microscopes for data collection, and a satellite 100 kV microscope for specimen screening.
Cryo-Electron Microscopy Laboratory website