Ivan Maillard’s main interest is to investigate the signals regulating the development and function of blood-forming stem cells. He studies the specialized microenvironment that nurtures blood-forming stem cells, using the mouse as a model organism.
In particular, Dr. Maillard investigates how these cells are supported in fetal hematopoietic organs, such as the fetal liver, the main site of blood development during fetal life before migration of blood-forming stem cells into the bone marrow. Understanding these interactions will lead to novel strategies to expand blood-forming stem cells in culture or to enhance their function after transplantation. In addition, it might provide insights into the function of stem cells in other contexts, including in cancerous tissues.
Another interest of the Maillard laboratory is in the self-renewal and differentiation of mature T lymphocytes, a subset of lymphocytes that plays a critical role in immunization, anti-cancer responses and diseases such as AIDS and autoimmune disorders.
Dr. Maillard earned his MD at the University of Lausanne, Switzerland and a PhD in Immunology from the MD-PhD program of the Swiss Academy of Medical Sciences. His graduate work with Heidi Diggelmann, MD, aimed at understanding the complex interaction of mouse retroviruses with the immune system of their host. He subsequently completed a post-doctoral fellowship with Warren S. Pear at the University of Pennsylvania, where he also worked as an instructor and physician in Hematology-Oncology. There, Maillard investigated the role of signals delivered by the Notch pathway in the development of lymphocytes and in the homeostasis of blood-forming stem cells. His work was supported by a fellowship from the Damon Runyon Cancer Research Foundation.
He joined the Life Sciences Institute as a Research Associate Professor and is affiliated with the U-M Center for Stem Cell Biology. He is also an Associate Professor in the Department of Internal Medicine, Division of Hematology/Oncology.
- 2014-present: Leukemia director, University of Michigan Health System and University of Michigan Comprehensive Cancer Center, Ann Arbor, MI
- 2013-present: Associate Professor, Center for Stem Cell Biology, Department of Cell and Developmental Biology, Life Sciences Institute and Division of Hematology-Oncology, University of Michigan, Ann Arbor, MI
- 2007-2013: Assistant Professor, Center for Stem Cell Biology, Department of Cell and Developmental Biology, Life Sciences Institute and Division of Hematology-Oncology, University of Michigan, Ann Arbor, MI
- 2006-2007: Instructor in Medicine, Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA
- 2005-2007: Attending physician in Hematology-Oncology, Leukemia/BMT Unit, Hospital of the University of Pennsylvania, Philadelphia, PA
- 2002-2007: Post-doctoral fellow, Mentored by Warren S. Pear, MD-PhD, University of Pennsylvania, Philadelphia, PA
- 2004-2006: Research associate, Division of Hematology-Oncology, University of Pennsylvania School of Medicine
- 2001-2004: Fellow, Division of Hematology-Oncology, University of Pennsylvania School of Medicine
- 1997-2001: Resident in Internal Medicine and Hematology-Oncology, University of Lausanne Medical Center, Lausanne, Switzerland
- MD-PhD program, Swiss Academy of Medical Sciences, University of Lausanne, Switzerland, 1997
- Medical School, University of Lausanne and Zurich, Switzerland, 1993
- Baccalaureat (BA equivalent), Gymnase de Chamblandes, Lausanne, Switzerland
Honors and Awards
- 11/2014: League of Research Excellence, University of Michigan Medical School
- 11/2013: Jeffrey M. Leiden Collegiate Professorship in the Life Sciences, University of Michigan
- 4/2013: Elected member, American Society of Clinical Investigation (ASCI)
- 1/2013: Leukemia and Lymphoma Society Scholar Award
- 2/2012: Excellence in Research Award, Division of Hematology-Oncology, University of Michigan
- 3/2010: Kimmel Scholar Award in Cancer Research, Sidney Kimmel Foundation
- 2/2010: Early Career Development Award, Central Society for Clinical Research
- 1/2009: Damon Runyon Rachleff Innovation Award
- 12/2008: Junior Faculty Research Scholar Award, American Society of Hematology
- 10/2008: Best Poster Award, Taubman Medical Research Institute Symposium, University of Michigan
- 2/2008: Rackham Graduate School Faculty Research Grant, University of Michigan
- 2007-present: Biological Sciences Scholar, University of Michigan
- 2005-2007: Abbott Fellow, Damon Runyon Cancer Research Foundation, New York, USA
- 11/2006: Invited Seminar: Swiss institute for Experimental Cancer Research, Epalinges, CH
- 11/2006: Invited Seminar: Max Planck Institute of Immunobiology, Freiburg, Germany
- 10/2006: Invited Seminar: Fox Chase Cancer Center, Philadelphia, PA
- 04/2006: Invited Seminar: Abbott Pharmaceuticals, Abbott Park, IL
- 02/2006: European Commission's Scholarship and Best Poster Award, ESH-AACR conference, Cascais, Portugal
- 12/2004: Basic Research Scholar Award, American Society of Hematology (declined)
- 11/2004: Invited Seminar: Ludwig Institute for Cancer Research, Lausanne, Switzerland
- 2002-2004: Grant for Advanced Researcher, Swiss Society for Grants in Medicine and Biology, Bern, Switzerland
- 07/2000: Thesis Award, Faculty of Sciences, University of Lausanne, Switzerland
- 1994-1997: MD-PhD training grant, Swiss Academy of Medical Sciences and Max Cloetta Foundation, Basel/Zurich, Switzerland