Much of Anna Mapp's research focuses upon developing a molecular-level picture of inducible gene expression in eukaryotes using organic molecules as mechanistic probes. Regulated gene expression is critical for cellular existence, and a number of human diseases such as cancer and diabetes have been linked to aberrant patterns of gene expression. Therefore, a goal of primary importance in the scientific community is the discovery of transcription-based therapeutics capable of reprogramming gene expression in diseased cells while leaving normal cells unaffected. While a general sequence of events that leads to gene up-regulation is agreed upon, the molecular-level interactions that regulate the levels and time course of transcriptional activation remain unknown. A more detailed picture of gene regulation is a prerequisite for the eventual development of transcription-based therapeutics.
Mapp focuses on two approaches for identifying the relevant targets of activator proteins in the transcriptional machinery: the design and synthesis of organic molecules that mimic common protein structural motifs such as the helix, and understanding how multiple activator proteins function synergistically to up-regulate transcription and uncovering the regulatory role of transcriptional machinery composition.
Anna Mapp completed her A.B. in chemistry at Bryn Mawr College before moving to the University of California-Berkeley to complete the PhD under the direction of Professor Clayton H. Heathcock. Following postdoctoral work with Professor Peter B Dervan at Caltech, Mapp joined the faculty at the University of Michigan in 2000, where she is currently Professor of Chemistry and Director of the Program in Chemical Biology.
- A.B.: Bryn Mawr College
- PhD: University of California-Berkeley
- Postdoc: California Institute of Technology
- Emil Thomas Kaiser Award from the Protein Society 2015
- American Association for the Advancement of Science Fellow 2011
- Arthur C. Cope Scholar Award 2011
- Eli Lilly Award in Biological Chemistry 2007
- Amgen Young Investigator Award 2006
- LS&A Class of 1923 Memorial Teaching Award 2006
- (NSF) Presidential Early Career Awards for Scientists & Engineers 2005
- GlaxoSmithKline Chemistry Scholars Award 2005
- Alfred P. Sloan Foundation Fellowship in Chemistry 2004
- National Science Foundation Career Award 2004
- Basil O'Connor Starter Scholar Research Award 2002
- March of Dimes New Investigator in the Toxicological Sciences
- Research Innovation Award, Research Corporation