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Michigan Medicine enters drug discovery collaboration with AstraZeneca in Chronic Kidney Disease (11/9/2017)

U-M Structure Seminars, 2017-2018

Time and Place: Fridays from 10:30 - 11:30 a.m. in LSI library (except where noted)


Seminars of Interest, 2017-2018

Time and Place: Tuesdays at 12:00 p.m. in the Medical School North Hall (except where noted)

May 17, 2018: Erica Ollmann Saphire, The Scripps Research Institute, Greenberg Lecture

November 27, 2018: Sylvie Doublie, University of Vermont

Previous U-M Structure Seminars

February 23, 2018: ​"Crystal Structure of the C-terminal Guanine Exchange Factor Module of Trio Reveals its Oncogenic Potential,​" Sumit Bandekar, Tesmer Lab

February 9, 2018: "Structure-based design of inhibitors with improved selectivity for steroidogenic cytochrome P450 17A1 over cytochrome P450 21A2," Rahul Yadav, Ph.D., Scott Lab

January 19, 2018: "Structural studies of TBK1 and IKKε to aid in the development of new obesity and diabetes therapeutics," Tyler Beyett, Tesmer Lab

December 15, 2017: "Recruiting and Activating Telomerase," Val Tesmer, Ph.D.

December 8, 2017: "Cloud computing tools for cryo-EM,” Michael Cianfrocco, Ph.D.

December 1, 2017: "APOBEC3H structure reveals a unique mechanism of interaction with RNA," Jen Bohn, Smith Lab

November 17, 2017: "Crystal Structure of Cobalamin-dependent Methionine synthase from Thermus thermophilus HB8," Kazuhiro Yamada, Ph.D., Koutmos lab

November 3, 2017: "Dual-function of human Sestrin2 and amino acid sensing by mTORC1," Hanseong Kim, Ph.D., Cho Lab

October 27, 2017: "Structure, Function, and Inhibition of Novel GI Microbial Beta-Glucuronidase Drug Targets," Rebecca Pollet, Koropatkin Lab

October 20, 2017: "Structure-Based Mechanism of Histones H3 and H4 Nuclear Import Mediated by Kap123," by Sojin An, Ph.D., Cho Lab

October 13, 2017: Claire Cato, Tesmer Lab

September 22, 2017: "Fragment Screening and Other Small Molecule Interaction Assays Using Biacore Surface Plasmon Resonance Instruments" by Eric Roush, Ph.D, Biacore

May 5, 2017: "Mechanism and Specificity of Human DNA Ligase 1" by Tom Jurkiw, O'Brien Lab

April 14, 2017: “Structure and Function of Human (Membrane) Cytochrome P450 Enzymes:  From Drug Metabolism to Cancer Therapy” by Emily Scott, Ph.D.

April 7, 2017: "Structurally perTERBing the telomere – inner nuclear membrane interface" by Devon Pendlebury, Nandakumar Lab

March 24, 2017: "Structural and Functional Characterization of Human Nocturnin, a 3' to 5' Exonuclease Implicated by Obesity" by Elizabeth Abshire, Trievel Lab

March 17, 2017: "A dynamic lid provides a structural explanation for LCAT activation by ApoA-I" by Kelly Manthei, Tesmer Lab

March 10, 2017: "Quinazolinones as Novel Non-Covalent Inhibitors of Penicillin-Binding Proteins" by Renee Bouley, Tesmer Lab

February 24, 2017: "Biogenesis of the core ring system in Hapalindole type alkaloids: mechanistic insight from a crystal structure of the HpiC1 cyclase" by Sean Newmister, Sherman Lab

February 17, 2017: "Development of BCL6 protein-protein interaction inhibitors using fragment based approach" by Brian Linhares, Cierpicki Lab

January 20, 2017: "Dissecting the Autoinhibition Mechanism of TrioC" by Sumit Bandekar, Tesmer Lab

January 13, 2017: "Arrestin activation? just press the right button" by Qiuyan Chen, Tesmer Lab

January 6, 2017: "Three Activities in One Domain: Characterizing a Multifunctional Dehydratase from Gephryonic Acid PKS" by Greg Dodge, Smith Lab

December 9, 2016: "Structural insights into class C GPCR signaling” by Alys Peisley, Skiniotis Lab - CANCELLED

November 18, 2016 "Structure-Based Design of Kinase Inhibitors for the Treatment of Obesity and Type II Diabetes" by Tyler Beyett, Tesmer Lab

November 11, 2016: "Ongoing efforts of defining Hsp70’s interactions with substrates and co-factors”, by Erik Zuiderweg, Zuiderweg Lab

November 4, 2016: "Modular Methylation in Polyketide Biosynthesis", by Meredith Skiba, Smith Lab

October 28, 2016: “Investigations of Eukaryotic Translation Machineries through Single Particle Cryo-EM”, by Ben Ami Moran, Skiniotis Lab

October 21, 2016: "Structural Changes in the Telomere Protein TPP1 Cause a Bone Marrow Failure Disease" by Eric Smith, Nandakumar Lab

October 14, 2016: “Structural and functional insights into the multi-purpose flavivirus protein NS1” by David Akey, Smith Lab

October 7, 2016: Structural and Functional Characterization of the Metastatic Factor P-Rex1 and its Regulation by PIP3: Towards Inhibitory Small Molecule Development by Jennifer Cash, Tesmer Lab

September 30, 2016: The Structural Biology Data Grid @SBGrid: Raw data publication with live analysis, byb Jason Key, Ph.D, Technical Project Leader, SBGrid

September 9, 2016: "Natural Product Biosynthetic Initiation though the Formation of Aromatic and Fatty Acid Adenylates" by Andy Sikkema, Janet Smith Lab

July 1, 2016: Structure and evolution of CTP synthase filaments: metabolic regulation by polymer assembly, Justin Kollman, Ph.D., Assistant Professor, Department of Biochemistry, University of Washington

May 6, 2016:  Tools for the Characterization of Protein Stability, Riffard Jean-Gilles, MS, Field Application Scientist, Unchained Labs

April 15, 2016:  Function of an S•••O Chalcogen Bond in the Lysine Methyltransferase SET7/9­, Robert Fick, Ray Trievel Lab

April 8, 2016:  Crystal structure of Fluc, a double-barrelled fluoride channel by Randy Stockbridge, Ph.D., Assistant Professor of Biophysics & Assistant Professor of Molecular, Cellular and Developmental Biology

April 1, 2016: Assembly of the Starch utilization system (Sus) of Bacteroides thetaiotaomicron by Matthew Foley,  Nicole Koropatkin Lab

March 18, 2016: Cyclopropanation and double bond reduction in polyketide biosynthesis: a covalent substrate-cofactor intermediate by Dheeraj Khare, Janet Smith Lab

March 4, 2016: Resistant Starch Utilization by the Human Gut Microbiome by Darrell Cockburn, Nicole Koropatkin Lab

February 26, 2016: Substrate Specificity in Polyketide Synthase Dehydratase Domains by Greg Dodge, Janet Smith Lab

February 19, 2016:  Crowdsourcing Crystallography by Scott Horowitz, James Bardwell Lab

February 12, 2016: Biochemical and Structural Studies on Yeast Vps4 Oligomerization by Emily Guo, Zhaohui Xu Lab

January 22, 2016: Structural and Biochemical Studies Towards Understanding the Activation Mechanism of LCAT by Kelly Manthei, John Tesmer Lab

January 15, 2016: Capturing Dynamic Chaperone-Substrate Binding with NMR-Informed Molecular Modeling by Logan Ahlstrom, James Bardwell Lab

December 18, 2015:  Deciphering gliotoxin biosynthesis in Aspergillus fumigatus, by Daniel Scharf, Georgios Skiniotis Lab

December 11, 2015: Cryo-EM studies of ribosomes, by Yan Zhang, Georgios Skiniotis Lab

December 4, 2015: Investigation of the marine natural product oxaline: biosynthesis and beyond, by Sean Newmister, David Sherman Lab

November 20, 2015: Hsp70 chaperones: binding the kitchen sink is an understatement by Erik Zuiderweg, Ph.D.

November 13, 2015: Structural Biology Services at Cayman Chemical: Developing Small Molecule Inhibitors of Human Autotaxin, by Adam Stein, Cayman Chemical

November 6, 2015: Structure, Function and Engineering of Bacterial Microcompartments by external speaker Cheryl A. Kerfeld, Ph.D., Dept. of Biochemistry & Molecular Biology, Plant Research Lab at Michigan State, and Physical Biosciences Division at Lawrence Berkeley National Lab

October 23, 2015: MR-REX: cooperative molecular replacement search by replica-exchange Monte Carlo simulations, by Jouko Virtanen, Yang Zhang Lab

October 16, 2015: Understanding regulation of P-Rex by cell membrane-anchored molecules, by Jennifer Cash, John Tesmer Lab

Friday, May 22, 2015: Probing CH--O Hydrogen Bonding in Methyltransferases using Structural Biochemistry, Quantum Mechanics and Unnatural Amino Acid Mutagenesis, by Ray Trievel, Ph.D.

Friday, May 15, 2015: Special External Talk: Realizing the full potential of single particle electron cryomicroscopy in structural biology by Richard Henderson, Ph.D., Cambridge, MRC Laboratory of Molecular Biology.

Friday, May 1, 2015: Visualizing Chaperone-Mediated Protein Folding by Residual Electron and Anomalous Density Selection, by Scott Horowitz, Ph.D., James Bardwell Lab

Friday, April 24, 2015: Target gene specificity in the p53 family of transcription factors, by Hector Viadiu, Ph.D., National Autonomous University of Mexico

Friday, April 10, 2015: Structure of CurD, the initiating enzyme of Curacin β-Branching, in complex with a cognate ACP, by Finn Maloney, Janet Smith Lab

Friday, March 6, 2015: Cocaine Esterase: A bacterial protein that can treat cocaine toxicity and addiction in humans, Joey Nichols, Roger Sunahara Lab

Friday, February 27, 2015: Characterization of the metastatic factor P-Rex1 and its regulation by PIP3, Jennifer Cash, Ph.D., John Tesmer Lab

Friday, February 20, 2015: Toward a snapshot of G protein inhibition by Cholera Toxin, Nicolas Villanueva, Roger Sunahara Lab

Friday, February 13, 2015: Cryo-EM structure validation, Somnath Dutta, Georgios Skiniotis Lab

Friday, February 6, 2015: NMR studies of Hsp70 chaperone/co-chaperone complexes, Erik Zuiderweg, Ph.D.

Friday, January 30th, 2015: Structural basis of GPCR activation, Xavier Deupi, Ph.D., Paul Scherer Institute, Switzerland, hosted by Georgios Skiniotis

Friday, January 16th, 2015: Crystal structure of an oddball termination domain in Carmabin A biosynthesis, Dheeraj Khare, Janet Smith Lab

Friday, January 9th, 2015: The starch degradation systems of the gut microorganisms Eubacterium rectale and Ruminococcus bromii, Darrell Cockburn, Nicole Koropatkin Lab

UM Structure Seminars 2014 and before.

Previous Seminars of Interest

May 1, 2018: Tamir Gonen, HHMI Janeila Research Campus, "MicroED opens a new era for biological structure determination”

April 24, 2018: Akif Tezcan, University of California, San Diego, "Chemical Design of Functional Protein Assemblies”

April 17, 2018: Angela Gronenborn, Univeristy of Pittsburgh

April 10, 2018: Tom Steitz, Yale University, Ludwig Lecture, Kahn Auditorium BSB

March 27, 2018: Patrick Cramer, Max Planck Institute for Biophysical Chemistry

March 14, 2018: "The Molecular Mechanisms of Microtubule-Based Intracellular Transport” 
Samara Reck-Peterson, Ph.D., Professor, Department of Cellular and Molecular Medicine, Div. of Biological Sciences, Howard Hughes Medical Institute, University of California, San Diego
9:30 to 10:30 a.m., Kahn Auditorium, Biomedical Sciences Research Building

March 13, 2018:  Song Tan, Pennsylvania State University

March 6, 2018: Combating Antibiotic Resistance Through Biophysics and Structure,” Rebecca Page, Ph.D., Professor, Chemistry and Biochemistry, College of Medicine and the College of Science at The University of Arizona

February 27, 2018: Angela Gronenborn, University of Pittsburgh

February 20, 2018: Mike Cianfrocco, University of Michigan Life Sciences Institute

December 12, 2017: Ailong Ke, Cornell University
12:00pm, North Lecture Hall, Med Sci II           

November 30, 2017: Eric Tse, Southworth lab, Thesis defense,
11:00 a.m., Medical Science Building I, Room 6311

October 19, 2017: Amanda Wong, Dissertation Seminar
3:00 p.m., Medical Science Building I, Room 3330

October 24, 2017: "Interdependence, Reflexivity, Fidelity, Impedance Matching, and the Evolution of Genetic Coding," by Charlie Carter, University of North Carolina, Chapel Hill

September 25, 2017: Dorit Hanein, Sanford Burnham Prebys Medical Discovery Institute
11:00 a.m., Forum Hall, Palmer Commons
January 11, 2017: Nino Campobasso, GlaxoSmithKline
12:00pm, 2903 THSL
December 13, 2016: Gianluigi Veglia, University of Minnesota
12:00pm, North Lecture Hall, Med Sci II
December 6, 2016: Bil Clemons, CalTech
12:00pm, North Lecture Hall, Med Sci II
December 5, 2016: Jennifer Bridwell-Rabb, Massachusetts Institute of Technology
4:00-5:30pm, Chem 1640 Chemistry & Willard H Dow Laboratory

November 30, 2016:

"Molecular visualization of microtubules and and transcription complexes using cryo-EM"
Eva Nogales, Ph.D., Investigator, Howard Hughes Medical Institute and Professor of Molecular and Cell Biology at the University of California, Berkley
12:00pm, BSRB, ABC
November 15, 2016: 12:00pm, North Lecture Hall, Med Sci II
"Signaling and Regulation Mechanisms of the Guidance Receptor Plexin”
Xuewu Zhang, UT Southwestern Medical School
Department of Biological Chemistry Seminar Series
Host: John Tesmer, Ph.D.
October 18, 2016: Luke Rice, UT Southwestern Medical School
12:00pm, North Lecture Hall, Med Sci II
September 27, 2016: Xiaodong Cheng, Dept. Biochemistry, Emory University
12:00pm, North Lecture Hall, Med Sci II
September 21, 2016: Brian Kobilka, M.D., "Structural Insights into the Dynamic Process of G Protein Coupled Receptor Activation"
1:30pm, Kahn Auditorium, BSRB
September 20, 2016: Emily Scott, Dept. of Medicinal Chemistry, U-M College of Pharmacy
12:00pm, North Lecture Hall, Med Sci II
September 19, 2016: Computational Biology Symposium
9am-12pm, Kahn Auditorium, BSRB
Tuesday, April 26, 2016, 12 – 1 P.M.
Martha L Ludwig Lectureship in Structural Biology
Cynthia Wolberger, John Hopkins School of Medicine
Tuesday April 19, 2016, 12-1 P.M.
Traci Hal, National Institute of Environmental Health Sciences
"RNA Recognition and Regulation by Pumilio Family Proteins"
Biological Chemistry, Seminar, North Lecture Hall, Med Sci II
Host: Ray Treivel

Tuesday, April 12, 2016, 12 – 1 P.M.
Tatiana Kutalteladze, UC Denver
Biological Chemistry, Seminar, North Lecture Hall, Med Sci II
Host: Ray Treivel

Thursday, March 17, 2016, 4 - 5 P.M.
Rhett A. Kovall, Ph.D., Associate Professor, University of Cincinnati College of Medicine
"Structure & Function of the Corepressor MINT/SHARP: a Negative Regulator of Notch Signaling"
Pathology Research Seminar, 4234 Med Sci I

Friday, March 11, 2016, 4 - 5:00 p.m.
Linda Columbus, Ph.D., Associate Professor of Chemistry and Molecular Physiology and Biological Physics, University of Virginia
"Hijacking Pathogenic Membrane Proteins To Engineer Cellular Entry: A Molecular Biophysics Approach"
Biophysics Seminar, Room 1300 Chemistry

Thursday, March 3, 2016, 12:00 p.m.
Susan Buchanan, Ph.D., Principal Investigator, Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases 
"Structural insight into the biogenesis of beta barrel membrane proteins"
3330 Medical Science I
Hosted by Nicole Koropatkin, Ph.D.

Friday, January 22, 2016, 4pm
Sarah Keane, University of Maryland, Baltimore County
"Structure of the HIV-1 5' Leader"
Biophysics Seminar, 1300 Chemistry

Friday, January 8, 2016, 4pm
Jonathan Schlebach, Vanderbilt University School of Medicine
“The Safety Dance: Biophysics of Membrane Protein Misfolding and Disease”
Biophysics Seminar, 1300 Chemistry

Tuesday, December 1, 2015, 12 – 1 P.M.
Gianluigi Veglia, Ph.D.
"Role of Conformational Dynamics in the Canonical and Non-Canonical Functions of Kinases"
Biological Chemistry, Seminar, North Lecture Hall, Med Sci II
Host: Erik Zuiderweg

Tuesday, November 17, 2015, 12 – 1 P.M.
Dr. Wenqing Xu, University of Washington
"Structural Dissection of Key Drug Targets in Wnt Signaling: Nuclear β-catenin, PARylation-Dependent Axin Turnover and Beyond"
Biological Chemistry, Seminar, North Lecture Hall, Med Sci II
Host: Uhn-Soo Cho, Ph.D.

Friday, October 30, 2015, 4-5 pm
Oncley Lecture in Biophysics
"Motion: The Hallmark of Life. From Marsupials to Molecules"
Speaker: Martin Karplus, Nobel Laureate (Chemistry, 2013), Theodore William Richards, Professor of Chemistry, Emeritus, Harvard University
Location: Rackham Amphitheatre

Tuesday, October 20, 2015, 12 – 1 P.M.
Christine Dunham, Emory University
Mechanisms to Regulate Gene Expression by Disrupting Protein Synthesis
Location: Biological Chemistry, Seminar, North Lecture Hall, Med Sci II
Host: Yiorgo Skiniotis

Friday, October 16, 2015, 12:00 PM - 1:00 PM
Ronald T. Raines, Ph.D., Henry Lardy Professor of Biochemistry, Linus Pauling Professor of Chemical Biology, Professor of Chemistry, University of Wisconsin, Madison
“Unappreciated Forces that Stabilize Proteins”
Location: Palmer Commons, Forum Hall, 4th Floor

Wednesday, October 7, 2015, 3:30 - 4:45 p.m.
David E. Shaw, Ph.D., Chief Scientist of D.E. Shaw Research, Senior Research Fellow of the Center for Computational Biology and Bioinformatics, Columbia University
“Simulating the Motion of Proteins and Drug Molecules: Implications for Science and Medicine"
Location: Kahn Auditorium BSRB

Thursday, October 1, 2015 10:30 - 11:30 a.m.
Dr. Eric Betzig, Ph.D.
HHMI, Janelia Farm Research Campus
2014 Nobel Prize in Chemistry for development of super-resolution PALM microscopy
Location: NLH, 3695 MS II

September 22, 2015, 12 – 1 P.M.
Michael F. Summers, Ph.D., Professor and Howard Hughes Investigator
University of Maryland, Baltimore County
Structure of the HIV-1 RNA Packaging Signal
Biological Chemistry, Seminar, North Lecture Hall, Med Sci II
Host: Ruma Banerjee, Ph.D.

September 17, 2015, 12:00 pm to 1:00 pm
Manajit Hayer-Hartl, Max Planck Institute of Biochemistry
Location: TBD
Host: Dan Southworth

Tuesday, September 15, 2015, 12 – 1 P.M.
Traci Hall, National Institute if Environmental Health Sciences
Biological Chemistry, Seminar, North Lecture Hall, Med Sci II
Host: Aaron Goldstrohm

Tuesday, May 26, 2015
10th Annual Symposium of the NIH-funded Chemistry-Biology Interface Training Program
Keynote Lecture 3-4 p.m.
Cathy Drennan, HHMI Professor and Investigator, Departments of Chemistry and Biology, Massachusetts Institute of Technology
Biomedical Sciences Research Building, Kahn auditorium

Tuesday, April 28, 2015, 12 – 1 P.M.
David Baker, Ph.D.- Greenberg Lecturer
Post-Evolutionary Biology: Design of novel protein structures, functions and assemblies
Biological Chemistry, Seminar, North Lecture Hall, Med Sci II
Host: Dave Engelke

Friday, April 17th, 4 - 5 P.M.
Klaus Gawrisch, National Institute on Alcohol Abuse & Alcoholism, NIH
Biophysics Seminar, 1300 Chemistry

Thursday, April 16, 2015, 10 - 11 A.M.
Structure, Function, Immunity
Steven Almo, Ph.D., Wollowick Family Foundation Chair in Multiple Sclerosis and Immunology
Albert Einstein College of Medicine
BSRB – Seminar Rooms ABC
Host: Biomedical Engineering

Tuesday, March 31, 2015, 12 – 1 P.M.
Histone Chaperones in nucleosome assembly and disassembly
Karolin Luger, Colorado State University- Ludwig Lectureship
Biological Chemistry, Seminar, North Lecture Hall, Med Sci II
Host: Dave Engelke

Friday, March 20, 2015, 4 - 5 P.M.
HIV - 1 Capsid Assembly, Maturation & Host Cell Interactions
Peijun Zhang, Dept. of Structural Biology, Univ. of Pittsburgh School of Medicine
Biophysics Seminar, 1300 Chemistry

Tuesday, March 17, 2015, 12 – 1 P.M.
Rachel Green, John Hopkins University
Biological Chemistry, Seminar, North Lecture Hall, Med Sci II
Host: Daniel Southworth

Tuesday, March 10, 2015, 12 – 1 P.M.
Marta Filizola, Icahn School of Medicine at Mount Sinai
Biological Chemistry, Seminar, North Lecture Hall, Med Sci II
Host: Yiorgio Skiniotis

Monday, January 26, 2015, 4 - 5 P.M.
"Microbial Resistance to Toxic Fluoride: Structural & Functional Features of Fluoride Channels & Transporters"
Dr. Randy Stockbridge, Department of Biochemistry, Brandeis University
Biophysics & MCDB Faculuty Candidate Seminar, 1300 Chemistry

Friday, January 23, 2015, 4 - 5 P.M.
"Illuminating biology at the nanoscale with super-resolution imaging"
Xiaowei Zhuang, Howard Hughes Medical Institute Investigator, Harvard University
Biophysics Seminar, 1300 Chemistry

Friday, January 9, 2015, 4 - 5 P.M.
Lukas Tamm, Dept. of Molecular Physiology & Biological Physics, Univ. of Virginia
Biophysics Seminar, 1300 Chemistry

Seminars of Interest 2014 and before.