S. Xu publications



*Co-corresponding authors;  +Co-first authors 

Zhang, B.+, Gong, J.+, Zhang, W., Xiao, R., Liu, J.*, and Xu, X.Z.S.* (2018) Brain-gut communications via distinct neuroendocrine signals bi-directionally regulate longevity in C. elegans.  Genes & Development 32, 258-70

Rauthan, M.+, Gong, J.+, Liu, J., Li, Z., Liu, J., and Xu, X.Z.S. (2017) microRNA regulation of nAChR expression and nicotine-dependent behavior in C. elegans.  Cell Reports  21, 1434-41

Meng, Z.X., Gong, J., Chen, Z., Sun, J., Xiao, Y., Wang, L., Li, Y., Liu, J., Xu X.Z.S., and Lin, J.D. (2017) Glucose sensing by skeletal myocytes couples nutrient signaling to systemic homeostasis.  Molecular Cell  66, 332-34 


Gong, J., Yuan, Y., Ward, A., Kang, L., Zhang, B., Wu, Z., Peng, J., Feng, Z., Liu, J.*, and Xu, X.Z.S.* (2016) The C. elegans taste receptor homolog LITE-1 is a photoreceptor.  Cell  167, 1252-63.   PubMed link

Li, Z.+, Iliff, A.J.+, and Xu, X.Z.S. (2016) An elegant circuit for balancing risk and reward.  Neuron 92, 933-5(preview)

Li, G., Gong, J., Lei, H., Liu, J., and Xu, X.Z.S. (2016) Promotion of behavior and neuronal function by reactive oxygen species in C. elegans.   Nature Communications  7, 13234.  PubMed link

Chaudhuri, J., Bose, N., Gong, J., Hall, D., Rifkind, A., Bhaumik, D, Peiris, T.H., Chamoli, M., Le, C.H., Liu, J., Lithgow, G.J., Ramanathan, A., Xu, X.Z.S., and Kapahi, P. (2016) A Caenorhabditis elegans model elucidates a conserved role for TRPA1-Nrf signaling in reactive α-dicarbonyl detoxification.  Current Biology  26, 3014-25.  PubMed link

Wang, X.+, Li, G.+, Liu, J., Liu, J., and Xu, X.Z.S. (2016) TMC-1 mediates alkaline sensation in C. elegans via nociceptive neurons.  Neuron  91, 146-54.   PubMed link

Xu, X.Z.S. (2016) Demystifying mechanosensitive Piezo ion channels. Neuroscience Bulletin 32, 307-9(highlight).  PubMed link

Li, L., Lei, H., Arey, R.N., Li, P., Liu, J., Murphy, C.T.*, Xu, X.Z.S.*, and Shen, K.* (2016) The neuronal kinesin UNC-104/KIF1A is a key regulator of synaptic aging and insulin signaling-regulated memory and lifespan.  Current Biology  26, 605-15.   PubMed link

Wescott, S.A., Ronan, E.A., and Xu, X.Z.S. (2016) Insulin signaling genes modulate nicotine-induced behavioral responses in C. elegans. Behavioural Pharmacology  27, 44-49.   PubMed link


Chun, L., Gong, J., Yuan, F., Zhang, B., Liu, H., Zheng, T., Yu, T., Xu, X.Z.S.*, and Liu, J.* (2015) Metabotropic GABA signalling modulates longevity in C. elegans.    Nature Communications 6, 8828.   PubMed link

Xiao, R. and Xu, X.Z.S. (2015) Thermosensation and longevity. J. of Comp. Physiol. A (review) 201, 857- 67.    PubMed link    

Hardaway, J.A., Whitaker, S.M., Snarrenberg, C.L., Li, Z., Xu, X.Z.S., Bermingham, D.P., Odiase, P., Spencer, W.C., Miller, D.M., Carvelli, L., Hardie, S.L., and Blakely, R.D. (2015) Glial expression of the Caenorhabditis elegans gene swip-10 supports glutamate dependent control of extrasynaptic dopamine signaling.  Journal of Neuroscience 35, 9409-23.   PubMed link 

Zhang, B., Xiao, R., Ronan, E.A., He, Y., Liu, J.*, and Xu, X.Z.S.* (2015) Environmental temperature differentially modulates C. elegans longevity through a thermosensitive TRP channel.  Cell Reports 11, 1414-24.   PubMed link 

Xiao, R., Chun, L., Ronan, E.A., Friedman, D.I., Liu, J., and Xu, X.Z.S. (2015) RNAi interrogation of dietary modulation of development, metabolism, behavior, and aging in C. elegans.  Cell Reports 11, 1123-33.   PubMed link    


Yadlapalli, S.+, Wani, K.A.+, and Xu, X.Z.S. (2014) Past experience resets behavior: CaMK takes the heat.  Neuron  84, 883-885(preview).    PubMed link

Li, Z., Liu, J., Zheng, M., and Xu, X.Z.S. (2014) Encoding of both analog- and digital-like behavioral outputs by one C. elegans interneuron.  Cell  159, 751-765.  (cover story)   PubMed link


Liu, J., Zhang, B., Feng, Z., Liu, J., Hsu, A.L., and Xu, X.Z.S. (2013) Functional aging in the nervous system contributes to age-dependent motor activity decline in C. elegansCell Metabolism 18, 392-402.  (cover story   PubMed link

Xiao, R., Zhang, B., Dong, Y., Gong, J., Xu, T., Liu, J., and Xu, X.Z.S. (2013) A genetic program promotes C. elegans longevity via a thermosensitive TRP channel.  Cell  152, 806-817. PubMed link

Wescott, S.A.+, Rauthan, M.+, and Xu, X.Z.S. (2013) When a TRP goes bad: Transient receptor potential channels in addiction.  Life Sciences (review) 92, 410-414. PubMed link


Singaravelu, G., Chatterjee, I., Rahimi, S., Druzhinia, M.K., Kang, L., Xu, X.Z.S., and Singson, A. (2012) The sperm surface localization of the TRP-3/SPE-41 calcium channel depends on SPE-38 function in Caenorhabditis elegans.  Dev. Biol. 365, 376-83. PubMed link

Zheng, M., Cao, P., Yang, J., Xu, X.Z.S.*, and Feng, Z.* (2012). Calcium imaging of multiple neurons in freely-behaving C. elegans.  Journal of Neuroscience Methods 206, 78-82. PubMed link

Park, E.C., Ghose, P., Shao, Z., Ye, Q., Kang, L., Xu, X.Z.S., Powell-Coffman, J.A., Rongo, C. (2012). Oxygen levels regulate glutamate receptor trafficking through a HIF-independent mechanism.  EMBO Journal 31, 1379-93. PubMed link

Zhang, D., Isack, N.R., Glodowski, D.R., Liu, J., Chen, C.C., Xu, X.Z.S., Grant, B.D., Rongo, C. (2012). RAB-6.2 and the retromer regulate glutamate receptor recycling through a retrograde transport pathway.  Journal of Cell Biology 196, 85-101. PubMed link


Piggott, B.J.+, Liu, J.+, Feng, Z.+, Wescott, S.A., and Xu, X.Z.S. (2011). The neural circuits and synaptic mechanisms underlying motor initiation in C. elegans.  Cell  147, 922-933. PubMed link

Kang, L., Wescott, S., Li, W., and Xu, X.Z.S. (2011). In touch: the molecular basis of mechanosensory transduction.  The Biochemist 33, 18-20 (review).   PubMed link

Li, W., Piggott, B.J., Feng, Z., and Xu, X.Z.S. (2011). The neural circuits and sensory channels mediating harsh touch sensation in Caenorhabditis elegans.  Nature Communications  2, 315. PubMed link

Xiao, R., and Xu, X.Z.S. (2011). C. elegans TRP channels.  Advances in Exp. Med. & Biol. 704, 323-39 (review). PubMed link


Xiao, R., and Xu, X.Z.S. (2010). Mechanosensitive channels: in touch with piezo.  Current Biology 20, R936-938 (dispatch). PubMed link

Wang GJ, Kang L, Kim JE, Maro GS, Xu, X.Z.S., and Shen, K. (2010). GRLD-1 regulates cell-wide abundance of glutamate receptor through post-transcriptional regulation.  Nature Neuroscience 13, 1489-1495. PubMed link

Kang, L.+, Gao, J.+, Schafer, W.R., Xie, Z., and Xu, X.Z.S. (2010). C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel.  Neuron  67, 381-391. PubMed link

Liu, J.+, Ward, A.+, Gao, J., Dong, Y., Nishio, N., Inada, H., Kang, L., Yu, Y., Ma, D., Xu, T., Mori, I., Xie, Z., and Xu, X.Z.S. (2010). C. elegans phototransduction requires a G protein-dependent cGMP pathway and a taste receptor homolog.  Nature Neuroscience  13, 715-722. PubMed link


Ward, A., Walker, V.J., Feng, Z., and Xu, X.Z.S. (2009). Cocaine modulates locomotion behavior in C. elegans.  PLoS ONE  4, e5946. PubMed link

Xiao, R., and Xu, X.Z.S. (2009). Function and regulation of TRP family channels in C. elegans.  Pflugers Arch. 458, 851-60 (review). PubMed link


Ward, A.+, Liu, J.+, Feng, Z., and Xu, X.Z.S. (2008). Light-sensitive neurons and channels mediate phototaxis in C. elegans.  Nature Neuroscience 11, 916-622. PubMed link

Hsu, A.L.*+, Feng, Z.+, Hsieh, M.Y., and Xu, X.Z.S.* (2008). Identification by machine vision of the rate of motor activity decline as a lifespan predictor in C. elegans.  Neurobiology of Aging 30, 1498-1503 [Epub Feb 5, 2008]. PubMed link


Feng, Z.+, Li, W.+, Ward, A., Piggott, B.J., Larkspur, E., Sternberg, P.W., and Xu, X.Z.S. (2006). A C. elegans model of nicotine-dependent behavior: regulation by TRP-family channels.  Cell  127, 621-633. PubMed link

Li, W., Feng, Z., Sternberg, P.W., and Xu, X.Z.S. (2006). A C. elegans stretch receptor neuron revealed by a mechanosensitive TRP channel homologue.  Nature  440, 684-687. PubMed link



Xu, X.Z.S., & Sternberg, P.W. (2003). A C. elegans sperm TRP protein required for sperm-egg interactions during fertilization.  Cell  114, 285-297. PubMed link

Xu, X.Z.S., Moebius, F., Gill, D.L., & Montell, C. (2001). Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform.  Proc. Natl. Acad. Sci. USA 98, 10692-10697. PubMed link

Xu, X.Z.S., Chien, F., Butler, A., Salkoff, L., & Montell, C. (2000). TRP gamma, a Drosophila TRP-related subunit, forms a regulated cation channel with TRPL.  Neuron 26, 647-657. PubMed link

Wes, P.D.+Xu, X.Z.S.+, Li, H.S., Chien, F., Doberstein, S.K., and Montell, C. (1999). Termination of phototransduction requires binding of the NINAC myosin III and the PDZ protein INAD.  Nature Neuroscience 2, 447-453. PubMed link

Li, H.S., Xu, X.Z.S., & Montell, C. (1999). Activation of a TRPC3-dependent cation current through the neurotrophin BDNF.  Neuron  24, 261-273. PubMed link

Xu, X.Z.S., Wes, P.D., Chen, H., Li, H.S., Yu, M.J., Morgen, S., Liu, Y., & Montell, C. (1998). Retinal targets for calmodulin include proteins implicated in synaptic transmission.  J. Biol. Chem. 273, 31297-31307. PubMed link

Xu, X.Z.S., Choudhury, A., Li, X. L., & Montell, C. (1998). Coordination of an array of signaling proteins through homo- and heteromeric interactions between PDZ domains and target proteins.  J. Cell Biol. 142, 545-555. PubMed link

Xu, X.Z.S.+, Li, H.S.+, Guggino, W.B., & Montell, C. (1997). Coassembly of TRP and TRPL produces a distinct store-operated conductance.  Cell  89, 1155-1164. PubMed link