Lee publications

Janssens, D.H., Hamm, D.C., Anhezini, L., Xiao, Q., Siller, K.H., Siegrist, S.E., Harrison, M.M., & Lee, C.Y. (2017). A Hdac1/Rpd3-poised circuit balances continual self-renewal and rapid restriction of developmental potential during asymmetric stem cell division. Developmental Cell, in press | PDF

Komori, H., Xiao, Q., Janssens, D.H., Dou, Y., & Lee, C.Y. (2014). Trithorax maintains the functional 1 heterogeneity of neural stem cells through the transcription factor Buttonhead. eLife 2014;10.7554/eLife.03502 PubMed link | PDF

Kuang, C., Golden, K.L., Simon, C.R., Damrath, J., Buttitta, L., Gamble, C., & Lee, C.Y. (2014). A novel Fizzy/Cdc20-dependent mechanism suppresses necrosis in neural stem cells. Development 141:1453-64 PubMed link \ PDF

Janssens, D.H., Komori, H., Grbac, D., Chen, K., Koe, C.T., Wang, H., & Lee, C.Y. (2014). dFezf/Earmuff restricts progenitor cell potential by attenuating the competence to respond to self-renewal factors. Development  141:1036-1046 PubMed link \ PDF

Komori, H., Xiao, Q., McCartney, B., & Lee, C.Y. (2014). Brain tumor specifies intermediate progenitor cells by attenuating β-catenin/Armadillo activity. Development 141:51-62. PubMed linkPDF

Xiao, Q., Komori, H., & Lee, C.Y. (2012). klumpfuss distinguishes stem cells from progenitor cells during asymmetric neuroblast division. Development 139:2670-2680. PubMed link | PDF

Haenfler, J.M., Kuang, C., & Lee, C.Y. (2012). Cortical aPKC kinase activity distinguishes neural stem cells from progenitor cells by ensuring asymmetric segregation of Numb. Developmental Biology 365:219-28. PubMed link | PDF

Weng, M., Haenfler, J.M., & Lee, C.Y. (2011). Changes in Notch signaling coordinates maintenance and differentiation of the Drosophila larval optic lobe neuroepithelia. Dev Neurobiol. PubMed link | PDF

Weng, M., Golden, K.L., & Lee, C.Y. (2010). dFezf/Earmuff maintains the restricted developmental potential of intermediate neural progenitors in Drosophila. Developmental Cell 18:126-135. PubMed link | PDF

Lee, C.Y., Andersen, R.O., Cabernard, C., Manning, L., Tran, K.D., Lanskey, M.J., Bashirullah, A., & Doe, C.Q. (2006). Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation. Genes & Development 20:3464-74. PubMed link

Lee, C. Y., Wilkinson, B. D., Siegrist, S. E., Wharton, R. P., & Doe, C. Q. (2006). Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal. Developmental Cell 10:441-449. PubMed link

Lee, C. Y., Robinson, K. J., & Doe, C. Q. (2006). lgl, pins and aPKC regulate neuroblast self-renewal versus differentiation. Nature 439:594-598. PubMed link

Lee, C. Y., Clough, E. A., Yellon, P., Teslovich, T. M., Stephan, D. A., & Baehrecke, E. H. (2003). Genome-wide analyses of steroid- and radiation- triggered programmed cell death in Drosophila. Current Biology 13:350-357. PubMed link

Rolls, M. M., Albertson, R., Shih, H. P., Lee, C. Y., & Doe, C. Q. (2003). Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia. Journal of Cell Biology 163, 1089-1098. PubMed link

Lee, C. Y., Cooksey, B. A. K., & Baehrecke, E. H. (2002). Steroid regulation of midgut cell death during Drosophila development. Developmental Biology 250:101-111. PubMed link

Lee, C. Y., Simon, C. R., Woodard, C. T., & Baehrecke, E. H. (2002). Genetic mechanism for the stage- and tissue-specific regulation of steroid triggered programmed cell death in Drosophila. Developmental Biology 252:138-148. PubMed link

Lee, C. Y., & Baehrecke, E. H. (2001). Steroid regulation of autophagic programmed cell death during development. Development 128"1443-1455. PubMed link

Lee, C. Y., Wendel, D. P., Reid, P., Lam, G., Thummel, C. S., & Baehrecke, E. H. (2000). E93 directs steroid-triggered programmed cell death in Drosophila. Molecular Cell 6:433-443. PubMed link

Review Articles

Janssens, D.H., & Lee, C.Y. (2014). It takes two to tango, a dance between the cells of origin and cancer stem cells in the Drosophila larval brain. Sem. Cell Dev. Biology   PubMed link \ PDF

Weng, M., & Lee, C.Y. (2010). Keeping neural progenitor cells on a short leash during Drosophila neurogenesis. Curr Opin Neurobiol 1:36-42. PubMed link

Lee, C. Y., & Baehrecke, E. H. (2000). Genetic regulation of programmed cell death in Drosophila. Cell Research 10:193-204. PubMed link.

Methods Papers

Weng, M. & Lee, C.Y. (2012). Identification of neural stem cells in the Drosophila brain. Methods Mol Biol. 879:39-46. PubMed Link

Daul, A.L., Komori, H., & Lee, C.Y. (2010). Multicolor fluorescence RNA in situ hybridization of Drosophila brain tissue.  Cold Spring Harbor Protoc. Jul 1; 2010.  PubMed Link

Daul, A.L., Komori, H., & Lee, C.Y. (2010). EdU (5-ethynyl-2'-deoxyuridine) labeling of Drosophila mitotic neuroblasts.  Cold Spring Harbor Protoc. Jul 1; 2010.  PubMed Link

Daul, A.L., Komori, H., & Lee, C.Y. (2010). Immunofluorescent staining of Drosophila larval brain tissue.  Cold Spring Harbor Protoc. Jul 1; 2010.  PubMed Link