Melanie Ohi

Our Research

The Ohi lab's research interest focuses on dissecting the structural organization of large macromolecular machines. Our goal is to use structure as a springbord to understand function within the context of cells.

Our laboratory uses single particle cryo-electron microscopy (cryo-EM) in combination with biophysical, biochemical, and genetic approaches to structurally and functionally characterize biologically important but structurally challenging molecular machines. We have exciting projects studying the machinery involved in gene regulation, bacterial pathogenesis, and membrane remodeling proteins.

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About Melanie Ohi

Research Associate Professor
  • cryo-electron microscopy
  • genetics
  • biochemistry


Melanie Ohi's reserach focuses on dissecting the structural and functional organization of the spliceosome, generating mechanistic models for how pore-forming toxins secreted by pathogenic bacteria transition from soluble to membrane inserted states, and studying the ways proteins can structurally influence membrane organization.

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Lab News

The Ohi lab is looking to recruit students and post-doctoral fellows.

Melanie and Mike Cianfrocco write an overview of cryo-EM in reponse to the Nobel Prize announcement for cryo-EM October 4, 2017

The Ohi lab joined the LSI on Sept. 1, 2017.

Recent Publications