Cianfrocco Lab Publications

Intracellular transport

Lis1 has two opposing modes of regulating cytoplasmic dynein. DeSantis ME*, Cianfrocco MA*, Htet ZM*, Tran PT, Reck-Peterson SL#, Leschziner AE#.  Cell. 2017 170(6): 1197-1208. [Article] [bioRxiv]

Mechanism and regulation of cytoplasmic dynein. Cianfrocco MA*, DeSantis ME*, Leschziner AE, Reck-Peterson SL#. Annu Rev Cell Dev Biol. 2015;31:83-108. doi: 10.1146/annurev-cellbio-100814-125438. Epub 2015 Sep 30. Review. [PubMed]

Traffic control: adaptor proteins guide dynein-cargo takeoff. Cianfrocco MA, Leschziner AE#. EMBO J. 2014 Sep 1;33(17):1845-6. doi: 10.15252/embj.201489450. Epub 2014 Jul 24. No abstract available. [PubMed]

Cloud computing & tools for cryo-EM

Generative adversarial networks as a tool to recover structural information from cryo-electron microscopy data. Su M, Zhang H, Schawinski K, Zhang C, Cianfrocco MA#. bioRxiv [bioRxiv]

An integrated, pipeline-based approach for cryo-EM structure determination and atomic model refinement in the cloud. Cianfrocco MA#, Lahiri I, DiMaio F, Leschziner AE. bioRxiv [bioRxiv]

Big data in cryoEM: automated collection, processing, and accessibility of EM data. Baldwin PR, Tan YZ, Eng ET, Rice WJ, Noble AJ, Negro CJ, Cianfrocco MA, Potter CS, Carragher#. Curr Opin Microbiol. 2017 Oct 31; 43:1-8 [PubMed]

Demo: COSMIC2 – A science gateway for cryo-electron microscopy. Cianfrocco MA#, Wong M. 2017. Presented at Gateways 2017. Ann Arbor, MI October 23-25. [PDF]

COSMIC2: A Science Gateway for Cryo-Electron Microscopy. Cianfrocco MA#, Wong M, Youn C, Wagner R, Leschziner AE. Presented at Practice & Experience in Advanced Research Computing. 2017.  New Orleans, LA July 9-13. [PDF]

Low cost, high performance processing of single particle cryo-electron microscopy data in the cloud. Cianfrocco MA#, Leschziner AE. eLife. 2015 May 8;4. doi: 10.7554/eLife.06664. [PubMed][bioRxiv][GitHub][Data Dryad][EMDB-2858][figShare]

Collaborations & previous work

Structural basis for the initiation of eukaryotic transcription-coupled DNA repair. Xu J*, Lahiri I*, Wang W, Wier A, Cianfrocco MA, Chong J, Hare AA, Dervan PB, DiMaio F, Leschziner AE, Wang D. Nature. 2017 [PubMed]

p53 Dynamically Directs TFIID Assembly on Target Gene Promoters. Coleman RA, Qiao Z, Singh SK, Peng CS, Cianfrocco MA, Zhang Z, Piasecka A, Aldeborgh H, Basishvili G, Liu WL. Mol Cell Biol. 2017 Jun 15;37(13). [PubMed][bioRxiv]

Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding. Cui J, Zhu Q, Zhang H, Cianfrocco MA, Leschziner AE, Dixon JE#, Xiao J. eLife. 2017 Apr 22;6. pii: e23990. doi: 10.7554/eLife.23990. [PubMed]

Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies. Ciferri C, Chandramouli S, Leitner A, Donnarumma D, Cianfrocco MA, Gerrein R, Friedrich K, Aggarwal Y, Palladino G, Aebersold R, Norais N, Settembre EC, Carfi A#. PLoS Pathog. 2015 Oct 20;11(10):e1005230. doi: 10.1371/journal.ppat.1005230. eCollection 2015 Oct. [PubMed]

Structural and biochemical studies of HCMV gH/gL/gO and Pentamer reveal mutually exclusive cell entry complexes. Ciferri C, Chandramouli S, Donnarumma D, Nikitin PA, Cianfrocco MA, Gerrein R, Feire AL, Barnett SW, Lilja AE, Rappuoli R#, Norais N, Settembre EC, Carfi A#. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1767-72. doi: 10.1073/pnas.1424818112. Epub 2015 Jan 26. [PubMed]

Substrate-specific structural rearrangements of human Dicer. Taylor DW, Ma E, Shigematsu H, Cianfrocco MA, Noland CL, Nagayama K, Nogales E, Doudna JA#, Wang HW#. Nat Struct Mol Biol. 2013 Jun;20(6):662-70. doi: 10.1038/nsmb.2564. Epub 2013 Apr 28. [PubMed]

Human TFIID binds to core promoter DNA in a reorganized structural state. Cianfrocco MA, Kassavetis GA, Grob P, Fang J, Juven-Gershon T, Kadonaga JT, Nogales E. Cell. 2013 Jan 17;152(1-2):120-31. doi: 10.1016/j.cell.2012.12.005. [PubMed][figShare][GitHub]

#Corresponding author

*Equal contributions 

View all of Michael Cianfrocco's publications on PubMed or Google Scholar.