The focus of our research is to address (1) how neuronal development contributes to the assembly and function of the nervous system and (2) how defects in this process lead to brain disorders. On neuronal development, we are interested in how neurons develop dendrites and axons into distinct subcellular compartments and how experience interacts with the genome to shape the nervous system. On brain disorders, we investigate the role of dysregulated expression levels of genes (e.g., in Down syndrome). We use both Drosophila and mice in our research, and take a multi-disciplinary approach that include genetics, cell biology, developmental biology, biochemistry, advanced imaging (for neuronal structures and activity), electrophysiology, computation, and behavioral studies.
- The development of dendrites, axons, and synapses in neurons
- Neuronal activity-dependent assembly of neural circuits
- Neurodevelopmental diseases
The laboratory of Bing Ye studies in how neuronal development contributes to the assembly and function of nervous systems and how defects in this process lead to diseases. Bing Ye is particularly interested in how experience and neuronal activity interact with the genome to shape the development of nervous system.
The Ye lab discovered how Dscam, a gene that's defective in Down syndrome, is regulated as well as how its dysregulation may lead to neurological defects, providing insights into potential therapeutic approaches to an aspect of the syndrome. The work was published June 5 in Neuron.
○ Kaneko T*, Macara AM*, Li R, Hu Y, Iwasaki K, Dunnings Z, Firestone E, Horvatic S, Guntur A, Shafer OT, Yang C-H, Zhou J, Ye B (2017) Serotonergic modulation enables pathway-specific plasticity in a developing sensory circuit in Drosophila. Neuron. 95: 623-638.
○ Wang X*, Zhang MW*, Kim JH, Macara AM, Sterne G, Yang T, and Ye B (2015) The Krüppel-like factor Dar1 determines multipolar neuron morphology. The Journal of Neuroscience. 35(42):14251-9.
○ Sterne GR*, Kim JH*, Ye B (2015) Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors. eLife 4:e05196.
○ Yang L, Li R, Kaneko T, Takle K, Morikawa RK, Essex LA, Wang X, Zhou J, Emoto K, Xiang Y, and Ye B (2014) Trim9 regulates activity-dependent fine-scale topography in Drosophila. Current Biology 24: 1024-1030.
○ Zhou W*, Chang J*, Wang X, Savelieff MG, Zhao Y, Ke S, and Ye B (2014) GM130 is required for compartmental organization of dendritic Golgi outposts. Current Biology 24: 1227-1233.
○ Kim JH*, Wang X*, Coolon R, and Ye B (2013) Dscam expression levels determine presynaptic arbor sizes in Drosophila sensory neurons. Neuron 78(5): 827-838.
○ Wang X, Kim JH, Bazzi M, Robinson S, Collins CA, and Ye B (2013) Bimodal Control of Dendritic and Axonal Growth by the Dual Leucine Zipper Kinase Pathway. PLoS Biology 11(6): e1001572.