The focus of our research is to address how neuronal development contributes to the assembly and function of nervous systems and how defects in this process lead to diseases (e.g. Down syndrome and autism). We are particularly interested in how experience and neuronal activity interact with the genome to shape the development of nervous system. To this end, we primarily use Drosophila as a system to investigate the development of dendrites, axons, synapses, and neural circuits, as well as pathogenic mechanisms underlying neurodevelopmental and neurodegenerative diseases. We also use mice to test the evolutionary conservation of the molecular mechanisms that we discover in Drosophila and use mouse models of human diseases to develop therapeutic strategies for neurodevelopmental diseases.
- The development of dendrites, axons, and synapses in neurons
- Neuronal activity-dependent assembly of neural circuits
- Neurodevelopmental diseases
The laboratory of Bing Ye studies in how neuronal development contributes to the assembly and function of nervous systems and how defects in this process lead to diseases. Bing Ye is particularly interested in how experience and neuronal activity interact with the genome to shape the development of nervous system.
The Ye lab discovered how Dscam, a gene that's defective in Down syndrome, is regulated as well as how its dysregulation may lead to neurological defects, providing insights into potential therapeutic approaches to an aspect of the syndrome. The work was published June 5 in Neuron.
○ Kaneko T*, Macara AM*, Li R, Hu Y, Iwasaki K, Dunnings Z, Firestone E, Horvatic S, Guntur A, Shafer OT, Yang C-H, Zhou J, Ye B (2017) Serotonergic modulation enables pathway-specific plasticity in a developing sensory circuit in Drosophila. Neuron. 95: 623-638.
○ Wang X*, Zhang MW*, Kim JH, Macara AM, Sterne G, Yang T, and Ye B (2015) The Krüppel-like factor Dar1 determines multipolar neuron morphology. The Journal of Neuroscience. 35(42):14251-9.
○ Sterne GR*, Kim JH*, Ye B (2015) Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors. eLife 4:e05196.
○ Yang L, Li R, Kaneko T, Takle K, Morikawa RK, Essex LA, Wang X, Zhou J, Emoto K, Xiang Y, and Ye B (2014) Trim9 regulates activity-dependent fine-scale topography in Drosophila. Current Biology 24: 1024-1030.
○ Zhou W*, Chang J*, Wang X, Savelieff MG, Zhao Y, Ke S, and Ye B (2014) GM130 is required for compartmental organization of dendritic Golgi outposts. Current Biology 24: 1227-1233.
○ Kim JH*, Wang X*, Coolon R, and Ye B (2013) Dscam expression levels determine presynaptic arbor sizes in Drosophila sensory neurons. Neuron 78(5): 827-838.
○ Wang X, Kim JH, Bazzi M, Robinson S, Collins CA, and Ye B (2013) Bimodal Control of Dendritic and Axonal Growth by the Dual Leucine Zipper Kinase Pathway. PLoS Biology 11(6): e1001572.