Composed of a dynamic, interdisciplinary team of scientists, the Sherman laboratory studies the biosynthesis of natural products from microbes that include cyanobacteria, actinomycetes, and myxobacteria. We are inspired by natural products from both terrestrial and marine organisms and seek to better understand their origins using a set of tools that includes molecular biology, genetics, biochemistry, structural biology, and bioorganic chemistry.
- Synthetic chemistry
- Marine microorganisms
- Drug discovery
David Sherman explores the biochemical pathways of marine microorganisms with the goal of finding new drug candidates for infectious diseases and cancers. He collects samples from marine and terrestrial sources around the world to build an extensive library of natural chemical compounds with potential disease-fighting capability.
Hansen, D. A., Koch, A. A., Sherman, D. H. 2017. Identification of a thioesterase bottleneck in the pikromycin pathway through full-module processing of unnatural pentaketides. J. Am. Chem. Soc. Aug 24. PubMed link
Koch, A. A., Hansen, D. A., Shende, V. V., Furan, L. R., Houk, K. N., Jiménez-Osés, G., Sherman, D. H. 2017. A single active site mutation in the pikromycin thioesterase generates a more effective macrocyclization catalyst. J. Am. Chem. Soc. Aug 24. PubMed link
Hagan, A. K., Tripathi, A., Berger, D., Sherman, D. H., Hanna, P. C. 2017. Petrobactin is exported from Bacillus anthracis by the RND-type exporter ApeX. mBio 8:e01238-17. PubMed link
Fraley, A. E., Garcia-Borràs, M., Tripathi, A., Khare, D., Mercado-Marin, E. V., Tran, H., Dan, Q., Webb, G., Watts, K., Crews, P., Sarpong, R., Williams, R. M., Smith, J. L., Houk, K. N., Sherman, D. H. 2017. Function and structure of MalA/MalA', iterative halogenases for late-stage C-H functionalization of indole alkaloids. J. Am. Chem. Soc. 139(34):12060-12068. PubMed link